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- W4313199044 abstract "Amphetamine metabolite p-hydroxyamphetamine (p-OHA) has been shown to have many pharmacological effects, including causing psychostimulant-induced behaviors such as hyperlocomotion and head-twitch response. We have previously reported that p-OHA induces prepulse inhibition (PPI) disruptions in mice, and the PPI disruptions are involved in the dopaminergic system. In this study, we investigated the involvement of the serotonin (5-HT) and noradrenaline (NA) neurotransmission in p-OHA-induced PPI disruptions in mice. As a result, p-OHA-induced PPI disruptions were attenuated by pretreatment with ketanserin (a 5-HT2A/2C receptor antagonist), MDL100,907 (a selective 5-HT2A receptor antagonist), 5,7-dihydroxytryptamine (a 5-HT neurotoxin), p-chlorophenylalanine (a 5-HT synthesis inhibitor) and prazosin (a selective α1 receptor antagonist), but were not attenuated by pretreatment with DSP-4 (a NA neurotoxin), fuzaric acid (a NA synthesis inhibitor). These results suggest that the 5-HT neurotransmission is strongly involved in p-OHA-induced PPI disruptions, with ancillary involved of α1 receptors." @default.
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- W4313199044 date "2022-01-01" @default.
- W4313199044 modified "2023-09-27" @default.
- W4313199044 title "<i>p</i>-Hydroxyamphetamine induced prepulse inhibition disruptions is modulated by serotonergic and adrenergic receptors" @default.
- W4313199044 doi "https://doi.org/10.1254/jpssuppl.96.0_3-b-p-232" @default.
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