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- W4313199250 abstract "Cells in our body are often exposed to hypoxic environment. In such environment, cells regulate respiration and metabolism for adaptation (hypoxic response). Hypoxic response not only plays a key role in maintaining homeostasis, but also in different diseases, such as cancer. Hypoxia-Inducible Factor (HIF) is a central transcription factor in hypoxic response. HIF is promptly up-regulated in hypoxia, and forms adapted cellular state. HIF has multiple target genes, and they coordinately regulate hypoxic response. Recently, HIF specific inhibitor was developed, and it is currently under clinical trial. Alternatively, we have demonstrated that HIF is downregulated, and CREB and NF-kB become activated during chronic phase of hypoxia. However, it remains unclear how the expression pattern of hypoxia-responsive genes changes depending on the timing." @default.
- W4313199250 created "2023-01-06" @default.
- W4313199250 creator A5038040069 @default.
- W4313199250 date "2022-01-01" @default.
- W4313199250 modified "2023-09-27" @default.
- W4313199250 title "Gene regulation during early and late phase of hypoxic response in cancer cells" @default.
- W4313199250 doi "https://doi.org/10.1254/jpssuppl.96.0_4-b-o12-3" @default.
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