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- W4313199573 abstract "Cyclic GMP-AMP (cGAMP) synthase (cGAS) and stimulator of interferon genes (STING) composes signal pathway which initiates innate immunity. 2'3'-cyclic GMP-AMP (cGAMP) is enzymatically produced by cGAS and activates several signaling pathway through binding to STING. Accumulating evidence indicates that cGAS-STING signaling play an important role in cancer, inflammatory disease, and senescence. Advanced glycation end products (AGEs) are biologically reactive compounds produced by prolonged exposure of proteins to carbonyl compounds. Chemical and physiological properties of AGEs depend on type of carbonyl compound. Accumulation of AGEs are observed in organs and tissues according to aging and leads to induction of proinflammatory effect. Therefore, AGEs are associated with the development of inflammatory and age-related diseases. However, relationship between cGAS-STING signal and AGEs remains unclear. In the present study, we investigate the effect of different types of AGEs on STING signal in macrophage. In THP-1 cells which is a human monocytic leukemia cell line, cGAMP transfection increased phosphorylation of TANK-binding kinase 1 (TBK1) and interferon regulatory factor 3 (IRF3), resulting in upregulation of IFNβ and CXCL10. Glycolaldehyde-derived AGEs dose-dependently suppressed cGAMP-induced the phosphorylation of TBK1 and IRF3. In contrast, ribose-derived AGEs enhanced the phosphorylation of TBK1 and IRF3. These results may suggest that different types of AGEs contribute to the regulation of STING signal in macrophage." @default.
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- W4313199573 date "2022-01-01" @default.
- W4313199573 modified "2023-09-27" @default.
- W4313199573 title "Regulation of STING signal by advanced glycation end products" @default.
- W4313199573 doi "https://doi.org/10.1254/jpssuppl.96.0_yia06-3" @default.
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