Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313199575> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W4313199575 endingPage "135" @default.
- W4313199575 startingPage "2" @default.
- W4313199575 abstract "The IKs channels, which contribute to the repolarization phase of the cardiac action potential, are composed of the alpha subunit KCNQ1 and beta subunit KCNE1. Mutations in these genes are associated with the development of lethal arrhythmias due to congenital QT prolongation syndrome and are influenced by sympathetic nerve stimulation and sex hormones. As a molecular mechanism, we have demonstrated the involvement of a molecular complex of the KCNQ1 channel in the IKs regulation by intracellular Ca2+, cAMP, and NO. Recently, membrane proteomics has shown an association between the KCNQ1 molecular complex and Ca2+ signaling, but the pathophysiological role of this association has not been elucidated. Therefore, we aimed to test whether IKs channels activated by pathological Ca2+ overload may compensate for arrhythmias using genetically engineered (IKs-Tg) mice expressing cardiac human IKs channels. We employed a sepsis model for pathological Ca2+ overload condition. We found that the sepsis score IKs-Tg mice was significantly lower than that in wild-type mice, suggesting a protective role of the IKs channel on cardiac pathological modification by sepsis." @default.
- W4313199575 created "2023-01-06" @default.
- W4313199575 creator A5000898179 @default.
- W4313199575 creator A5024566389 @default.
- W4313199575 creator A5033713449 @default.
- W4313199575 creator A5040966729 @default.
- W4313199575 creator A5058040672 @default.
- W4313199575 creator A5060462599 @default.
- W4313199575 creator A5067766967 @default.
- W4313199575 creator A5081048245 @default.
- W4313199575 creator A5081750013 @default.
- W4313199575 creator A5086016211 @default.
- W4313199575 date "2022-01-01" @default.
- W4313199575 modified "2023-09-27" @default.
- W4313199575 title "A study on a pathophysiological role of a macromolecular complex of the cardiac KCNQ1 channel" @default.
- W4313199575 doi "https://doi.org/10.1254/jpssuppl.96.0_2-b-p-135" @default.
- W4313199575 hasPublicationYear "2022" @default.
- W4313199575 type Work @default.
- W4313199575 citedByCount "0" @default.
- W4313199575 crossrefType "journal-article" @default.
- W4313199575 hasAuthorship W4313199575A5000898179 @default.
- W4313199575 hasAuthorship W4313199575A5024566389 @default.
- W4313199575 hasAuthorship W4313199575A5033713449 @default.
- W4313199575 hasAuthorship W4313199575A5040966729 @default.
- W4313199575 hasAuthorship W4313199575A5058040672 @default.
- W4313199575 hasAuthorship W4313199575A5060462599 @default.
- W4313199575 hasAuthorship W4313199575A5067766967 @default.
- W4313199575 hasAuthorship W4313199575A5081048245 @default.
- W4313199575 hasAuthorship W4313199575A5081750013 @default.
- W4313199575 hasAuthorship W4313199575A5086016211 @default.
- W4313199575 hasBestOaLocation W43131995751 @default.
- W4313199575 hasConcept C10162356 @default.
- W4313199575 hasConcept C118441451 @default.
- W4313199575 hasConcept C126322002 @default.
- W4313199575 hasConcept C134018914 @default.
- W4313199575 hasConcept C146403970 @default.
- W4313199575 hasConcept C185263204 @default.
- W4313199575 hasConcept C207886595 @default.
- W4313199575 hasConcept C2778384902 @default.
- W4313199575 hasConcept C2779703243 @default.
- W4313199575 hasConcept C71924100 @default.
- W4313199575 hasConcept C86803240 @default.
- W4313199575 hasConcept C95444343 @default.
- W4313199575 hasConceptScore W4313199575C10162356 @default.
- W4313199575 hasConceptScore W4313199575C118441451 @default.
- W4313199575 hasConceptScore W4313199575C126322002 @default.
- W4313199575 hasConceptScore W4313199575C134018914 @default.
- W4313199575 hasConceptScore W4313199575C146403970 @default.
- W4313199575 hasConceptScore W4313199575C185263204 @default.
- W4313199575 hasConceptScore W4313199575C207886595 @default.
- W4313199575 hasConceptScore W4313199575C2778384902 @default.
- W4313199575 hasConceptScore W4313199575C2779703243 @default.
- W4313199575 hasConceptScore W4313199575C71924100 @default.
- W4313199575 hasConceptScore W4313199575C86803240 @default.
- W4313199575 hasConceptScore W4313199575C95444343 @default.
- W4313199575 hasIssue "0" @default.
- W4313199575 hasLocation W43131995751 @default.
- W4313199575 hasOpenAccess W4313199575 @default.
- W4313199575 hasPrimaryLocation W43131995751 @default.
- W4313199575 hasRelatedWork W1966504330 @default.
- W4313199575 hasRelatedWork W1966775726 @default.
- W4313199575 hasRelatedWork W1974041167 @default.
- W4313199575 hasRelatedWork W1979139803 @default.
- W4313199575 hasRelatedWork W2030889776 @default.
- W4313199575 hasRelatedWork W2037631372 @default.
- W4313199575 hasRelatedWork W2040058909 @default.
- W4313199575 hasRelatedWork W2132898409 @default.
- W4313199575 hasRelatedWork W2748952813 @default.
- W4313199575 hasRelatedWork W4249176446 @default.
- W4313199575 hasVolume "96" @default.
- W4313199575 isParatext "false" @default.
- W4313199575 isRetracted "false" @default.
- W4313199575 workType "article" @default.