Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313199905> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W4313199905 endingPage "3" @default.
- W4313199905 startingPage "1" @default.
- W4313199905 abstract "Mast cells play a central role in IgE-dependent allergic responses. Engagement of antigen-specific IgE-bound FceRI with the same antigen induces mast cell degranulation, leading to the immediate hypersensitivity reaction. On the other hand, stimulation with cationic drugs (e.g., compound 48/80) induces IgE-independent degranulation of connective tissue mast cells via Mrgprb2, the murine homolog of MRGPRX2, leading to pseudo-allergic reaction. However, an inhibitory receptor CD300f down-regulates the excessive activation of mast cells in vivo. In fact, both FceRI-mediated anaphylactic responses and Mrgprb2-mediated pseudo-allergic responses are enhanced in CD300f-deficient mice compared to wild-type mice. We have previously identified ceramide as a ligand for CD300f. Consistently, administration of ceramide liposomes, prepared by using an extruder, inhibits both anaphylactic and pseudo-allergic responses in mice. In addition, we recently developed a new method to generate stable ceramide liposomes and demonstrated that intranasal administration of newly-generated ceramide liposomes inhibits ragweed pollen-induced allergic rhinitis in murine models. Thus, intranasal administration of ceramide liposomes will be a useful therapeutic strategy against allergic rhinitis." @default.
- W4313199905 created "2023-01-06" @default.
- W4313199905 creator A5014193228 @default.
- W4313199905 date "2022-01-01" @default.
- W4313199905 modified "2023-10-16" @default.
- W4313199905 title "The regulatory mechanisms of IgE-dependent and independent mast cell activation and allergic responses" @default.
- W4313199905 doi "https://doi.org/10.1254/jpssuppl.96.0_1-b-s08-3" @default.
- W4313199905 hasPublicationYear "2022" @default.
- W4313199905 type Work @default.
- W4313199905 citedByCount "0" @default.
- W4313199905 crossrefType "journal-article" @default.
- W4313199905 hasAuthorship W4313199905A5014193228 @default.
- W4313199905 hasBestOaLocation W43131999051 @default.
- W4313199905 hasConcept C141105273 @default.
- W4313199905 hasConcept C159654299 @default.
- W4313199905 hasConcept C170493617 @default.
- W4313199905 hasConcept C180899940 @default.
- W4313199905 hasConcept C185592680 @default.
- W4313199905 hasConcept C190283241 @default.
- W4313199905 hasConcept C203014093 @default.
- W4313199905 hasConcept C207480886 @default.
- W4313199905 hasConcept C2776914184 @default.
- W4313199905 hasConcept C2776953665 @default.
- W4313199905 hasConcept C2777851122 @default.
- W4313199905 hasConcept C2779675166 @default.
- W4313199905 hasConcept C2779726688 @default.
- W4313199905 hasConcept C49802076 @default.
- W4313199905 hasConcept C55493867 @default.
- W4313199905 hasConcept C71924100 @default.
- W4313199905 hasConcept C98274493 @default.
- W4313199905 hasConceptScore W4313199905C141105273 @default.
- W4313199905 hasConceptScore W4313199905C159654299 @default.
- W4313199905 hasConceptScore W4313199905C170493617 @default.
- W4313199905 hasConceptScore W4313199905C180899940 @default.
- W4313199905 hasConceptScore W4313199905C185592680 @default.
- W4313199905 hasConceptScore W4313199905C190283241 @default.
- W4313199905 hasConceptScore W4313199905C203014093 @default.
- W4313199905 hasConceptScore W4313199905C207480886 @default.
- W4313199905 hasConceptScore W4313199905C2776914184 @default.
- W4313199905 hasConceptScore W4313199905C2776953665 @default.
- W4313199905 hasConceptScore W4313199905C2777851122 @default.
- W4313199905 hasConceptScore W4313199905C2779675166 @default.
- W4313199905 hasConceptScore W4313199905C2779726688 @default.
- W4313199905 hasConceptScore W4313199905C49802076 @default.
- W4313199905 hasConceptScore W4313199905C55493867 @default.
- W4313199905 hasConceptScore W4313199905C71924100 @default.
- W4313199905 hasConceptScore W4313199905C98274493 @default.
- W4313199905 hasIssue "0" @default.
- W4313199905 hasLocation W43131999051 @default.
- W4313199905 hasOpenAccess W4313199905 @default.
- W4313199905 hasPrimaryLocation W43131999051 @default.
- W4313199905 hasRelatedWork W1571696686 @default.
- W4313199905 hasRelatedWork W1661858862 @default.
- W4313199905 hasRelatedWork W1977460101 @default.
- W4313199905 hasRelatedWork W2032975706 @default.
- W4313199905 hasRelatedWork W2083098487 @default.
- W4313199905 hasRelatedWork W2090682427 @default.
- W4313199905 hasRelatedWork W2561511743 @default.
- W4313199905 hasRelatedWork W3028993706 @default.
- W4313199905 hasRelatedWork W3034602543 @default.
- W4313199905 hasRelatedWork W3196011793 @default.
- W4313199905 hasVolume "96" @default.
- W4313199905 isParatext "false" @default.
- W4313199905 isRetracted "false" @default.
- W4313199905 workType "article" @default.