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- W4313199952 abstract "Brown adipocytes cause an energy consumption by heat production and are thought to be a target for the prevention of obesity and related metabolic disorders. Piezo1 is a Ca2+-permeable non-selective cation channel and activated by mechanical stimuli. While, Piezo1 has been reported to be involved in mechano-sensation in non-sensory tissues, the expression and role of Piezo1 in brown adipocytes have not been well clarified. In this study, we evaluated a brown adipocytes line from UCP1-mRFP1 transgenic mice and analyzed this cell. Application of Yoda-1, a Piezo1 agonistsuppressed brown adipocytes differentiation in a dose-dependent manner. This suppression was significantly recovered by co-application with a Piezo1 antagonist and a calcineurin inhibitor. In addition, knock-down of Piezo1 impaired Yoda-1-induced suppression of brown adipocyte differentiation and application of Yoda-1 enhanced the calcineurin activity. These results suggest that activation of Piezo1 might suppress the differentiation through calcineurin pathway in brown pre-adipocytes." @default.
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- W4313199952 date "2022-01-01" @default.
- W4313199952 modified "2023-09-24" @default.
- W4313199952 title "Activation of mechanosensitive Piezo1 channel suppresses brown adipocyte differentiation" @default.
- W4313199952 doi "https://doi.org/10.1254/jpssuppl.96.0_3-b-p-187" @default.
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