Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313200037> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W4313200037 endingPage "120" @default.
- W4313200037 startingPage "2" @default.
- W4313200037 abstract "Pulmonary arterial hypertension (PAH) results in right ventricular failure due to markedly elevated pulmonary arterial pressure and compensatory right ventricular hypertrophy. Although the involvement of tyrosine kinase (PTK) in the smooth muscle pathogenicities of PAH has been suggested, attempts to treat with a multi-target PTK inhibitor (PTKI) have not made sufficient progress due to harmful effects such as cardiotoxicity. In this study, we searched for PTK, whose expression is selectively increased in the hypertrophied right ventricular wall of PAH rats. RT-PCR targeting PTK domain consensus sequence was carried out for right ventricular wall (RV) and left ventricular wall with septum (LV+S) from monocrotaline-induced (MCT-) PAH rats and control rats. Southern hybridization was performed using various PTK probes derived from MCT-PAH rat RV. Selective increased expression of at least three types of PTK in MCT-PAH rat RV was observed, including PDGF-Rβ, which we previously reported its overexpression in pulmonary arteries of MCT-PAH rats. There was no difference in the expression of c-abl, which is thought to be involved in PTKI cardiotoxicity, in the LV+S and RV in both PAH and control rats. Our results suggest that a more specific inhibition of PTK isoform would be suitable for safely treating PAH using PTKI." @default.
- W4313200037 created "2023-01-06" @default.
- W4313200037 creator A5018109978 @default.
- W4313200037 creator A5033492106 @default.
- W4313200037 creator A5055073705 @default.
- W4313200037 creator A5062446462 @default.
- W4313200037 date "2022-01-01" @default.
- W4313200037 modified "2023-10-16" @default.
- W4313200037 title "Search for tyrosine kinases overexpressed in the hypertrophied right ventricular wall of monochromotaline-induced pulmonary hypertensive rats" @default.
- W4313200037 doi "https://doi.org/10.1254/jpssuppl.96.0_2-b-p-120" @default.
- W4313200037 hasPublicationYear "2022" @default.
- W4313200037 type Work @default.
- W4313200037 citedByCount "0" @default.
- W4313200037 crossrefType "journal-article" @default.
- W4313200037 hasAuthorship W4313200037A5018109978 @default.
- W4313200037 hasAuthorship W4313200037A5033492106 @default.
- W4313200037 hasAuthorship W4313200037A5055073705 @default.
- W4313200037 hasAuthorship W4313200037A5062446462 @default.
- W4313200037 hasBestOaLocation W43132000371 @default.
- W4313200037 hasConcept C126322002 @default.
- W4313200037 hasConcept C134018914 @default.
- W4313200037 hasConcept C164705383 @default.
- W4313200037 hasConcept C167414201 @default.
- W4313200037 hasConcept C170493617 @default.
- W4313200037 hasConcept C180361614 @default.
- W4313200037 hasConcept C185592680 @default.
- W4313200037 hasConcept C26635844 @default.
- W4313200037 hasConcept C2775960820 @default.
- W4313200037 hasConcept C2776694085 @default.
- W4313200037 hasConcept C2778233292 @default.
- W4313200037 hasConcept C2779376020 @default.
- W4313200037 hasConcept C2780930700 @default.
- W4313200037 hasConcept C2780940725 @default.
- W4313200037 hasConcept C42362537 @default.
- W4313200037 hasConcept C71924100 @default.
- W4313200037 hasConcept C84393581 @default.
- W4313200037 hasConceptScore W4313200037C126322002 @default.
- W4313200037 hasConceptScore W4313200037C134018914 @default.
- W4313200037 hasConceptScore W4313200037C164705383 @default.
- W4313200037 hasConceptScore W4313200037C167414201 @default.
- W4313200037 hasConceptScore W4313200037C170493617 @default.
- W4313200037 hasConceptScore W4313200037C180361614 @default.
- W4313200037 hasConceptScore W4313200037C185592680 @default.
- W4313200037 hasConceptScore W4313200037C26635844 @default.
- W4313200037 hasConceptScore W4313200037C2775960820 @default.
- W4313200037 hasConceptScore W4313200037C2776694085 @default.
- W4313200037 hasConceptScore W4313200037C2778233292 @default.
- W4313200037 hasConceptScore W4313200037C2779376020 @default.
- W4313200037 hasConceptScore W4313200037C2780930700 @default.
- W4313200037 hasConceptScore W4313200037C2780940725 @default.
- W4313200037 hasConceptScore W4313200037C42362537 @default.
- W4313200037 hasConceptScore W4313200037C71924100 @default.
- W4313200037 hasConceptScore W4313200037C84393581 @default.
- W4313200037 hasIssue "0" @default.
- W4313200037 hasLocation W43132000371 @default.
- W4313200037 hasOpenAccess W4313200037 @default.
- W4313200037 hasPrimaryLocation W43132000371 @default.
- W4313200037 hasRelatedWork W1976409316 @default.
- W4313200037 hasRelatedWork W1988466345 @default.
- W4313200037 hasRelatedWork W2343896499 @default.
- W4313200037 hasRelatedWork W2409871230 @default.
- W4313200037 hasRelatedWork W3030448595 @default.
- W4313200037 hasRelatedWork W3111581952 @default.
- W4313200037 hasRelatedWork W3148516409 @default.
- W4313200037 hasRelatedWork W3174224241 @default.
- W4313200037 hasRelatedWork W954123543 @default.
- W4313200037 hasRelatedWork W2181544182 @default.
- W4313200037 hasVolume "96" @default.
- W4313200037 isParatext "false" @default.
- W4313200037 isRetracted "false" @default.
- W4313200037 workType "article" @default.