Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313200207> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W4313200207 endingPage "272" @default.
- W4313200207 startingPage "4" @default.
- W4313200207 abstract "The development of sensorineural hearing loss is a serious problem because it significantly reduces the quality of life. Age-related, noise-induced, and drug-induced sensorineural hearing loss has been reported to decrease inner hair cell synapses (IHC synapses) in its early stages. This study aimed to determine the cause of this decrease in IHC synapses. We prepared the mice in which repeated exposure (1-h exposure per day, 5 times) to moderate noise (8-kHz octave band noise, 90 dB sound pressure level) induced gradual hearing impairment along with a loss of IHC synapses. Treatment with PLX3397 (macrophage-depletion drug, 290 mg/kg) significantly improved reduced the number of synapses and hearing impairment caused by repeated noise exposure. Treatment with minocycline (macrophage-activation inhibitor, 50 mg/kg) significantly improved reduced the number of synapses and hearing impairment caused by repeated noise exposure. These results suggest that intracochlear macrophages are activated by noise exposure and may negatively regulate the number of IHC synapses." @default.
- W4313200207 created "2023-01-06" @default.
- W4313200207 creator A5018426073 @default.
- W4313200207 date "2022-01-01" @default.
- W4313200207 modified "2023-09-27" @default.
- W4313200207 title "Intracochlear macrophages are involved in the development of sensorineural hearing loss by decreasing inner hair cell synapses" @default.
- W4313200207 doi "https://doi.org/10.1254/jpssuppl.96.0_4-b-p-272" @default.
- W4313200207 hasPublicationYear "2022" @default.
- W4313200207 type Work @default.
- W4313200207 citedByCount "0" @default.
- W4313200207 crossrefType "journal-article" @default.
- W4313200207 hasAuthorship W4313200207A5018426073 @default.
- W4313200207 hasBestOaLocation W43132002071 @default.
- W4313200207 hasConcept C115961682 @default.
- W4313200207 hasConcept C127445978 @default.
- W4313200207 hasConcept C154945302 @default.
- W4313200207 hasConcept C169760540 @default.
- W4313200207 hasConcept C2778585322 @default.
- W4313200207 hasConcept C2779356876 @default.
- W4313200207 hasConcept C2780130748 @default.
- W4313200207 hasConcept C2780493683 @default.
- W4313200207 hasConcept C2780607864 @default.
- W4313200207 hasConcept C3018332767 @default.
- W4313200207 hasConcept C41008148 @default.
- W4313200207 hasConcept C548259974 @default.
- W4313200207 hasConcept C71924100 @default.
- W4313200207 hasConcept C86803240 @default.
- W4313200207 hasConcept C99498987 @default.
- W4313200207 hasConceptScore W4313200207C115961682 @default.
- W4313200207 hasConceptScore W4313200207C127445978 @default.
- W4313200207 hasConceptScore W4313200207C154945302 @default.
- W4313200207 hasConceptScore W4313200207C169760540 @default.
- W4313200207 hasConceptScore W4313200207C2778585322 @default.
- W4313200207 hasConceptScore W4313200207C2779356876 @default.
- W4313200207 hasConceptScore W4313200207C2780130748 @default.
- W4313200207 hasConceptScore W4313200207C2780493683 @default.
- W4313200207 hasConceptScore W4313200207C2780607864 @default.
- W4313200207 hasConceptScore W4313200207C3018332767 @default.
- W4313200207 hasConceptScore W4313200207C41008148 @default.
- W4313200207 hasConceptScore W4313200207C548259974 @default.
- W4313200207 hasConceptScore W4313200207C71924100 @default.
- W4313200207 hasConceptScore W4313200207C86803240 @default.
- W4313200207 hasConceptScore W4313200207C99498987 @default.
- W4313200207 hasIssue "0" @default.
- W4313200207 hasLocation W43132002071 @default.
- W4313200207 hasOpenAccess W4313200207 @default.
- W4313200207 hasPrimaryLocation W43132002071 @default.
- W4313200207 hasRelatedWork W1522944646 @default.
- W4313200207 hasRelatedWork W1603770984 @default.
- W4313200207 hasRelatedWork W2063525705 @default.
- W4313200207 hasRelatedWork W2103170161 @default.
- W4313200207 hasRelatedWork W226448894 @default.
- W4313200207 hasRelatedWork W2747874956 @default.
- W4313200207 hasRelatedWork W3132417432 @default.
- W4313200207 hasRelatedWork W3154158577 @default.
- W4313200207 hasRelatedWork W73463280 @default.
- W4313200207 hasRelatedWork W93881532 @default.
- W4313200207 hasVolume "96" @default.
- W4313200207 isParatext "false" @default.
- W4313200207 isRetracted "false" @default.
- W4313200207 workType "article" @default.