Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313200344> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W4313200344 endingPage "4" @default.
- W4313200344 startingPage "2" @default.
- W4313200344 abstract "Human induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs) are increasingly being used for cardiac safety evaluation, disease modeling, and regenerative medicine. To date, the majority of cardiotoxicity studies have examined the acute drug effects. However, these studies lack information on the chronic effects of cardiotoxic compounds. Here, motion vector prediction (MVP) method was employed to invasively quantify contractile function over 10 days, then to test whether nobiletin has a protective effect against thecardiotoxicity of 8-days exposure to doxorubicin and erlotinib. The MVP method showed that doxorubicin (0.1 - 0.3 μM) significantly reduced contractility compared to erlotinib (0.3 - 3 μM), which has no cardiotoxicity, when administered for more than 5 days, and that the simultaneous addition of 0.03 μM nobiletin significantly reduced this cardiac depression by doxorubicin (0.1 - 0.3 μM). These results suggest that nobiletin is protective against the cardiotoxic effect of doxorubicin, and are promising for future drug discovery applications." @default.
- W4313200344 created "2023-01-06" @default.
- W4313200344 creator A5025039913 @default.
- W4313200344 creator A5041876394 @default.
- W4313200344 creator A5060462599 @default.
- W4313200344 creator A5067766967 @default.
- W4313200344 creator A5073083948 @default.
- W4313200344 date "2022-01-01" @default.
- W4313200344 modified "2023-09-27" @default.
- W4313200344 title "Protective effect of nobiletin against doxorubicin-induced cardiotoxicity in human iPS cell-derived cardiomyocytes." @default.
- W4313200344 doi "https://doi.org/10.1254/jpssuppl.96.0_2-b-ss01-4" @default.
- W4313200344 hasPublicationYear "2022" @default.
- W4313200344 type Work @default.
- W4313200344 citedByCount "0" @default.
- W4313200344 crossrefType "journal-article" @default.
- W4313200344 hasAuthorship W4313200344A5025039913 @default.
- W4313200344 hasAuthorship W4313200344A5041876394 @default.
- W4313200344 hasAuthorship W4313200344A5060462599 @default.
- W4313200344 hasAuthorship W4313200344A5067766967 @default.
- W4313200344 hasAuthorship W4313200344A5073083948 @default.
- W4313200344 hasBestOaLocation W43132003441 @default.
- W4313200344 hasConcept C104317684 @default.
- W4313200344 hasConcept C107459253 @default.
- W4313200344 hasConcept C126322002 @default.
- W4313200344 hasConcept C145103041 @default.
- W4313200344 hasConcept C185592680 @default.
- W4313200344 hasConcept C2776694085 @default.
- W4313200344 hasConcept C2778004101 @default.
- W4313200344 hasConcept C2778233292 @default.
- W4313200344 hasConcept C2778401301 @default.
- W4313200344 hasConcept C2779054382 @default.
- W4313200344 hasConcept C2779676291 @default.
- W4313200344 hasConcept C2781303535 @default.
- W4313200344 hasConcept C29730261 @default.
- W4313200344 hasConcept C39133596 @default.
- W4313200344 hasConcept C500558357 @default.
- W4313200344 hasConcept C55493867 @default.
- W4313200344 hasConcept C71924100 @default.
- W4313200344 hasConcept C98274493 @default.
- W4313200344 hasConceptScore W4313200344C104317684 @default.
- W4313200344 hasConceptScore W4313200344C107459253 @default.
- W4313200344 hasConceptScore W4313200344C126322002 @default.
- W4313200344 hasConceptScore W4313200344C145103041 @default.
- W4313200344 hasConceptScore W4313200344C185592680 @default.
- W4313200344 hasConceptScore W4313200344C2776694085 @default.
- W4313200344 hasConceptScore W4313200344C2778004101 @default.
- W4313200344 hasConceptScore W4313200344C2778233292 @default.
- W4313200344 hasConceptScore W4313200344C2778401301 @default.
- W4313200344 hasConceptScore W4313200344C2779054382 @default.
- W4313200344 hasConceptScore W4313200344C2779676291 @default.
- W4313200344 hasConceptScore W4313200344C2781303535 @default.
- W4313200344 hasConceptScore W4313200344C29730261 @default.
- W4313200344 hasConceptScore W4313200344C39133596 @default.
- W4313200344 hasConceptScore W4313200344C500558357 @default.
- W4313200344 hasConceptScore W4313200344C55493867 @default.
- W4313200344 hasConceptScore W4313200344C71924100 @default.
- W4313200344 hasConceptScore W4313200344C98274493 @default.
- W4313200344 hasIssue "0" @default.
- W4313200344 hasLocation W43132003441 @default.
- W4313200344 hasOpenAccess W4313200344 @default.
- W4313200344 hasPrimaryLocation W43132003441 @default.
- W4313200344 hasRelatedWork W1967098055 @default.
- W4313200344 hasRelatedWork W1970161838 @default.
- W4313200344 hasRelatedWork W1989268025 @default.
- W4313200344 hasRelatedWork W2028557451 @default.
- W4313200344 hasRelatedWork W2114627331 @default.
- W4313200344 hasRelatedWork W2916049297 @default.
- W4313200344 hasRelatedWork W2969504066 @default.
- W4313200344 hasRelatedWork W2998131233 @default.
- W4313200344 hasRelatedWork W32528152 @default.
- W4313200344 hasRelatedWork W4308740090 @default.
- W4313200344 hasVolume "96" @default.
- W4313200344 isParatext "false" @default.
- W4313200344 isRetracted "false" @default.
- W4313200344 workType "article" @default.