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- W4313200831 abstract "The introduction of substances into the bloodstream initiates a complex series of chemical reactions. The study of drug absorption, metabolization and excretion processes is relevant for a better understanding of current treatments, by providing a better understanding, which helps improve them or propose new methods. In this project we propose a novel model for drug absorption, which is obtained by coupling a ID full-body blood flow model with the Wagner-Nelson absorption equation for a single compartment model through two established elimination rates Ket. For our experiments, we take the constant values from previous studies on the intravenous administration of ibuprofen and epinephrine, having Ket = 0.32 per hour, and Ket = 0.2 per minute respectively, and one large Ket = 3200 per hour to test absorption in a detailed full-body model. Our result plots show a decay in the concentration of drug over the time, which reflects the correct coupling of our models with the subtraction of drug amounts and the update of the current drug concentration by the absorption model over our ID blood flow model. To overcome resources limitations, we run our simulations for short periods of time, with an increased Ket value in the same order to generate an accelerated decay of the drug concentration in a more detailed model." @default.
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- W4313200831 date "2022-01-01" @default.
- W4313200831 modified "2023-09-27" @default.
- W4313200831 title "Coupling 1D blood circulation model and substance absorption model to study drug metabolization" @default.
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- W4313200831 doi "https://doi.org/10.1016/j.procs.2022.10.213" @default.
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