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- W4313201375 endingPage "115371" @default.
- W4313201375 startingPage "115371" @default.
- W4313201375 abstract "The aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor regulating adaptive and maladaptive responses toward exogenous and endogenous signals. Research from various biomedical disciplines has provided compelling evidence that the AHR is critically involved in the pathogenesis of a variety of diseases and disorders, including autoimmunity, inflammatory diseases, endocrine disruption, premature aging and cancer. Accordingly, AHR is considered an attractive target for the development of novel preventive and therapeutic measures. However, the ligand-based targeting of AHR is considerably complicated by the fact that the receptor does not always follow the beaten track, i.e. the canonical AHR/ARNT signaling pathway. Instead, AHR might team up with other transcription factors and signaling molecules to shape gene expression patterns and associated physiological or pathophysiological functions in a ligand-, cell- and micromilieu-dependent manner. Herein, we provide an overview about some of the most important non-canonical functions of AHR, including crosstalk with major signaling pathways involved in controlling cell fate and function, immune responses, adaptation to low oxygen levels and oxidative stress, ubiquitination and proteasomal degradation. Further research on these diverse and exciting yet often ambivalent facets of AHR biology is urgently needed in order to exploit the full potential of AHR modulation for disease prevention and treatment." @default.
- W4313201375 created "2023-01-06" @default.
- W4313201375 creator A5000205913 @default.
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- W4313201375 creator A5031372655 @default.
- W4313201375 creator A5057735886 @default.
- W4313201375 date "2023-02-01" @default.
- W4313201375 modified "2023-10-15" @default.
- W4313201375 title "Functions of the aryl hydrocarbon receptor (AHR) beyond the canonical AHR/ARNT signaling pathway" @default.
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