FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313203952> ?p ?o ?g. }

• W4313203952 endingPage "19" @default.
• W4313203952 startingPage "1" @default.
• W4313203952 abstract "Demyelinating diseases such as multiple sclerosis (MS) are chronic inflammatory autoimmune diseases and involve demyelination and axonal degeneration. Microglia rapidly respond to changes in the environment by altering morphotype and function during the progressive disease stage. Although substantial progress has been made in the drug development for MS, treatment of the progressive forms of the disease remains unsatisfactory. There is great interest in identifying novel agents for treating MS. Lentinus edodes is a traditional food, which can improve physiological function. Lentinan (LNT), a type of polysaccharide extracted from mushroom Lentinus edodes, is an anti-inflammatory and immunomodulatory agent. Here, we studied the remyelination effects of LNT and its therapeutic target in regulating the functions of neuroinflammation. We found that LNT enhanced remyelination and rescued motor deficiency by regulating dectin-1 receptor to inhibit neuroinflammation and microglial cell transformation. LNT promoted the conversion of microglial cells from the M1 status induced by LPS to the M2 status, enhanced the anti-inflammatory markers IL-10 and BDNF, inhibited inflammatory markers TNF-α and IL-1β, and downregulated the microglia activation and oligodendrocyte and astrocyte proliferation by modulating dectin-1. If we injected the dectin-1-specific inhibitor laminarin (Lam), the remyelination effects induced by LNT were completely abolished. Thus, these results suggest that LNT is a novel and potential therapeutic agent that can rescue MS neuroimmune imbalance and remyelination through a dectin-1 receptor-dependent mechanism." @default.
• W4313203952 created "2023-01-06" @default.
• W4313203952 creator A5006794114 @default.
• W4313203952 creator A5006884460 @default.
• W4313203952 creator A5006916986 @default.
• W4313203952 creator A5011169222 @default.
• W4313203952 creator A5030542777 @default.
• W4313203952 creator A5032653868 @default.
• W4313203952 creator A5043022302 @default.
• W4313203952 creator A5043415956 @default.
• W4313203952 creator A5052073474 @default.
• W4313203952 creator A5067846870 @default.
• W4313203952 creator A5073216396 @default.
• W4313203952 creator A5077165659 @default.
• W4313203952 creator A5078669108 @default.
• W4313203952 date "2022-12-28" @default.
• W4313203952 modified "2023-10-16" @default.
• W4313203952 title "The Dectin-1 Receptor Signaling Pathway Mediates the Remyelination Effect of Lentinan through Suppression of Neuroinflammation and Conversion of Microglia" @default.
• W4313203952 cites W1495813857 @default.
• W4313203952 cites W1862817708 @default.
• W4313203952 cites W1964435410 @default.
• W4313203952 cites W1979787502 @default.
• W4313203952 cites W1984417027 @default.
• W4313203952 cites W1994603967 @default.
• W4313203952 cites W2002280017 @default.
• W4313203952 cites W2023538413 @default.
• W4313203952 cites W2033577622 @default.
• W4313203952 cites W2041016616 @default.
• W4313203952 cites W2048082433 @default.
• W4313203952 cites W2053150221 @default.
• W4313203952 cites W2056087291 @default.
• W4313203952 cites W2058956065 @default.
• W4313203952 cites W2082429191 @default.
• W4313203952 cites W2094660330 @default.
• W4313203952 cites W2102948520 @default.
• W4313203952 cites W2106105150 @default.
• W4313203952 cites W2112880160 @default.
• W4313203952 cites W2130699389 @default.
• W4313203952 cites W2139731923 @default.
• W4313203952 cites W2146324977 @default.
• W4313203952 cites W2147406541 @default.
• W4313203952 cites W2170191276 @default.
• W4313203952 cites W2178915804 @default.
• W4313203952 cites W2277756665 @default.
• W4313203952 cites W2469383593 @default.
• W4313203952 cites W2498973669 @default.
• W4313203952 cites W2526639432 @default.
• W4313203952 cites W2753755323 @default.
• W4313203952 cites W2891421333 @default.
• W4313203952 cites W2900554633 @default.
• W4313203952 cites W2904871119 @default.
• W4313203952 cites W2914008502 @default.
• W4313203952 cites W2914618279 @default.
• W4313203952 cites W2934110515 @default.
• W4313203952 cites W2950122557 @default.
• W4313203952 cites W2979176820 @default.
• W4313203952 cites W2998577441 @default.
• W4313203952 cites W3012139047 @default.
• W4313203952 cites W3023335497 @default.
• W4313203952 cites W3043273384 @default.
• W4313203952 cites W3123785483 @default.
• W4313203952 cites W3127341444 @default.
• W4313203952 cites W3133557906 @default.
• W4313203952 cites W3148661655 @default.
• W4313203952 cites W3169289077 @default.
• W4313203952 cites W3195674796 @default.
• W4313203952 cites W3197958064 @default.
• W4313203952 cites W3203119934 @default.
• W4313203952 cites W4206224953 @default.
• W4313203952 cites W4210604961 @default.
• W4313203952 doi "https://doi.org/10.1155/2022/3002304" @default.
• W4313203952 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36619719" @default.
• W4313203952 hasPublicationYear "2022" @default.
• W4313203952 type Work @default.
• W4313203952 citedByCount "3" @default.
• W4313203952 countsByYear W43132039522023 @default.
• W4313203952 crossrefType "journal-article" @default.
• W4313203952 hasAuthorship W4313203952A5006794114 @default.
• W4313203952 hasAuthorship W4313203952A5006884460 @default.
• W4313203952 hasAuthorship W4313203952A5006916986 @default.
• W4313203952 hasAuthorship W4313203952A5011169222 @default.
• W4313203952 hasAuthorship W4313203952A5030542777 @default.
• W4313203952 hasAuthorship W4313203952A5032653868 @default.
• W4313203952 hasAuthorship W4313203952A5043022302 @default.
• W4313203952 hasAuthorship W4313203952A5043415956 @default.
• W4313203952 hasAuthorship W4313203952A5052073474 @default.
• W4313203952 hasAuthorship W4313203952A5067846870 @default.
• W4313203952 hasAuthorship W4313203952A5073216396 @default.
• W4313203952 hasAuthorship W4313203952A5077165659 @default.
• W4313203952 hasAuthorship W4313203952A5078669108 @default.
• W4313203952 hasBestOaLocation W43132039521 @default.
• W4313203952 hasConcept C100817775 @default.
• W4313203952 hasConcept C169760540 @default.
• W4313203952 hasConcept C170493617 @default.
• W4313203952 hasConcept C203014093 @default.
• W4313203952 hasConcept C2776748855 @default.
• W4313203952 hasConcept C2776914184 @default.
• W4313203952 hasConcept C2777619251 @default.

• next