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- W4313206810 abstract "Abstract Placental inflammations (villitis) are accompanied by loss of the syncytiotrophoblast, which is the cellular barrier separating maternal blood from fetal tissue in the villous placenta. We propose that syncytiotrophoblast loss is mediated by adhesion of activated maternal monocytes. This hypothesis was tested with a co-culture model of peripheral blood monocytes and placental syncytiotrophoblasts. We find that LPS-activated monocytes adhere to interferon-γ (IFN-γ)-treated syncytiotrophoblasts via monocyte LFA-1 for >48 h, during which time the monocytes induce trophoblast apoptosis and subsequent damage of the trophoblast layer. Optimal monocyte-mediated syncytiotrophoblast death requires both lipopolysaccharide (LPS) and IFN-γ and is inhibited by either anti-tumor necrosis factor (TNF) antibody or epidermal growth factor. Syncytiotrophoblast damage is largely limited to culture surfaces in the vicinity of bound monocytes. These results show that activated maternal monocytes bound to the placental barrier can induce focal damage mediated by the inflammatory cytokine TNF-α and suggest a route for maternal leukocyte infiltration into the fetal stroma." @default.
- W4313206810 created "2023-01-06" @default.
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- W4313206810 date "2000-12-01" @default.
- W4313206810 modified "2023-10-17" @default.
- W4313206810 title "Monocytes adhering by LFA-1 to placental syncytiotrophoblasts induce local apoptosis via release of TNF-α. A model for hematogenous initiation of placental inflammations" @default.
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- W4313206810 doi "https://doi.org/10.1189/jlb.68.6.903" @default.
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