FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313215251> ?p ?o ?g. }

• W4313215251 endingPage "104101" @default.
• W4313215251 startingPage "104101" @default.
• W4313215251 abstract "Phenethyl Isothiocyanate (PEITC) has good pharmacological activities in treating many diseases. However, its application has been limited due to its high hydrophobicity, low dissolution profile, storage stability difficulties, and rapid clearance. The current study aimed to make PEITC-loaded biocompatible low-toxic nanoparticles (NPs) and evaluate their physicochemical features and anti-bacterial potential. BSA and PEG were utilized as biodegradable polymers to fabricate NPs by emulsification procedure, which was then optimized using the Box-Behnken design (BBD). The fabricated optimized PEITC NPs (Run: 12) showed lower mean particle size (185.6 ± 0.8nm), good polydispersity index (0.22 ± 0.02), and Zeta potential (−23.3 ± 0.5mV), with higher entrapment efficiency (94.36 ± 0.16%) and drug loading (80.14 ± 0.13%) suggesting higher colloidal stability and a larger amount of drug can be delivered at the target site. Drug-loaded BSA-PEG NPs showed a prolonged release of PEITC (89.72% in 24 h) from the BSA matrix following the Higuchi model (R2 value = 0.987). The optimized NPs and the free drug were further screened for anti-bacterial activity, where NPs exhibited more potent anti-bacterial activity than free PEITC against all four bacterial strains by presenting higher killing efficiency. In contrast, free PEITC elicited bacteriostatic activity only. Of all the strains, S. aureus alone was more susceptible to drug-loaded NPs/free drugs. These convincing results helped to further exploration for in vivo anti-bacterial activity. Prior to the in vivo bacterial eradication studies, the doses of NPs administered to the animals are ensured for safety and biocompatibility in both in vitro and in vivo studies. Finally, in a S. aureus-induced mice infection model, PEITC NPs showed a very significant decrease in the area of infection (n=4, p < 0.05) than the control, blank NPs and free drug-treated animal groups. The PEITC NPs decreased the bacterial infection to almost negligible, with approximately 15.2 folds decreased bacterial viability than the free drug." @default.
• W4313215251 created "2023-01-06" @default.
• W4313215251 creator A5029312325 @default.
• W4313215251 creator A5034760600 @default.
• W4313215251 creator A5068446102 @default.
• W4313215251 date "2023-02-01" @default.
• W4313215251 modified "2023-09-26" @default.
• W4313215251 title "Fabrication and optimization of BSA-PEG-loaded phenethyl isothiocyanate (PEITC) nanoparticles using Box-Behnken design for potential application in subcutaneous infection condition" @default.
• W4313215251 cites W1134336137 @default.
• W4313215251 cites W1485126799 @default.
• W4313215251 cites W1967896770 @default.
• W4313215251 cites W1975132504 @default.
• W4313215251 cites W1975773180 @default.
• W4313215251 cites W1992993767 @default.
• W4313215251 cites W2005419668 @default.
• W4313215251 cites W2019196406 @default.
• W4313215251 cites W2024257431 @default.
• W4313215251 cites W2083533532 @default.
• W4313215251 cites W2087414776 @default.
• W4313215251 cites W2097603366 @default.
• W4313215251 cites W2112326782 @default.
• W4313215251 cites W2147233344 @default.
• W4313215251 cites W2157551905 @default.
• W4313215251 cites W2204153331 @default.
• W4313215251 cites W2233083012 @default.
• W4313215251 cites W2331551237 @default.
• W4313215251 cites W2580784198 @default.
• W4313215251 cites W2749722012 @default.
• W4313215251 cites W2766044294 @default.
• W4313215251 cites W2804846127 @default.
• W4313215251 cites W2883392119 @default.
• W4313215251 cites W2885539360 @default.
• W4313215251 cites W2888691013 @default.
• W4313215251 cites W2901712937 @default.
• W4313215251 cites W2902380596 @default.
• W4313215251 cites W2902944417 @default.
• W4313215251 cites W2911919675 @default.
• W4313215251 cites W2935358028 @default.
• W4313215251 cites W2944068030 @default.
• W4313215251 cites W2947979837 @default.
• W4313215251 cites W2955358713 @default.
• W4313215251 cites W2977110700 @default.
• W4313215251 cites W2980122494 @default.
• W4313215251 cites W2996468770 @default.
• W4313215251 cites W2998392516 @default.
• W4313215251 cites W3006267881 @default.
• W4313215251 cites W3011041169 @default.
• W4313215251 cites W3022364753 @default.
• W4313215251 cites W3034126398 @default.
• W4313215251 cites W3047213958 @default.
• W4313215251 cites W3092712850 @default.
• W4313215251 cites W3096473443 @default.
• W4313215251 cites W3128549521 @default.
• W4313215251 cites W3129215346 @default.
• W4313215251 cites W3146917391 @default.
• W4313215251 cites W3173238181 @default.
• W4313215251 cites W3183464243 @default.
• W4313215251 cites W3184682232 @default.
• W4313215251 cites W3193455398 @default.
• W4313215251 cites W3197933142 @default.
• W4313215251 cites W3215233875 @default.
• W4313215251 cites W4200208794 @default.
• W4313215251 cites W4205904855 @default.
• W4313215251 cites W4210741433 @default.
• W4313215251 cites W4220917647 @default.
• W4313215251 cites W4296260755 @default.
• W4313215251 doi "https://doi.org/10.1016/j.jddst.2022.104101" @default.
• W4313215251 hasPublicationYear "2023" @default.
• W4313215251 type Work @default.
• W4313215251 citedByCount "0" @default.
• W4313215251 crossrefType "journal-article" @default.
• W4313215251 hasAuthorship W4313215251A5029312325 @default.
• W4313215251 hasAuthorship W4313215251A5034760600 @default.
• W4313215251 hasAuthorship W4313215251A5068446102 @default.
• W4313215251 hasConcept C10138342 @default.
• W4313215251 hasConcept C150077022 @default.
• W4313215251 hasConcept C150903083 @default.
• W4313215251 hasConcept C155672457 @default.
• W4313215251 hasConcept C162324750 @default.
• W4313215251 hasConcept C170295934 @default.
• W4313215251 hasConcept C171250308 @default.
• W4313215251 hasConcept C185592680 @default.
• W4313215251 hasConcept C192562407 @default.
• W4313215251 hasConcept C207001950 @default.
• W4313215251 hasConcept C2776572452 @default.
• W4313215251 hasConcept C2779820397 @default.
• W4313215251 hasConcept C2780740852 @default.
• W4313215251 hasConcept C43617362 @default.
• W4313215251 hasConcept C54400483 @default.
• W4313215251 hasConcept C55493867 @default.
• W4313215251 hasConcept C86181022 @default.
• W4313215251 hasConcept C86803240 @default.
• W4313215251 hasConceptScore W4313215251C10138342 @default.
• W4313215251 hasConceptScore W4313215251C150077022 @default.
• W4313215251 hasConceptScore W4313215251C150903083 @default.
• W4313215251 hasConceptScore W4313215251C155672457 @default.
• W4313215251 hasConceptScore W4313215251C162324750 @default.
• W4313215251 hasConceptScore W4313215251C170295934 @default.

• next