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• W4313216058 endingPage "201135" @default.
• W4313216058 startingPage "201135" @default.
• W4313216058 abstract "COVID-19 is a severe respiratory disease caused by SARS-CoV-2, a novel human coronavirus. Patients infected with SARS-CoV-2 exhibit heterogeneous symptoms that pose pragmatic hurdles for implementing appropriate therapy and management of the COVID-19 patients and their post-COVID complications. Thus, understanding the impact of infection severity at the molecular level in the host is vital to understand the host response and accordingly it's precise management. In the current study, we performed a comparative transcriptomics analysis of publicly available seven asymptomatic and eight severe COVID-19 patients. Exploratory data analysis employing Principal Component Analysis (PCA) showed the distinct clusters of asymptomatic and severe patients. Subsequently, the differential gene expression analysis using DESeq2 identified 1224 significantly upregulated genes (logFC≥ 1.5, p-adjusted value <0.05) and 268 significantly downregulated genes (logFC≤ -1.5, p-adjusted value <0.05) in severe samples in comparison to asymptomatic samples. Eventually, Gene Set Enrichment Analysis (GSEA) revealed the upregulation of anti-viral and anti-inflammatory pathways, secondary infections, Iron homeostasis, anemia, cardiac-related, etc.; while, downregulation of lipid metabolism, adaptive immune response, translation, recurrent respiratory infections, heme-biosynthetic pathways, etc. Conclusively, these findings provide insight into the enhanced susceptibility of severe COVID-19 patients to other health comorbidities including non-viral pathogenic infections, atherosclerosis, autoinflammatory diseases, anemia, male infertility, etc. owing to the activation of biological processes, pathways and molecular functions associated with them. We anticipate this study will facilitate the researchers in finding efficient therapeutic targets and eventually the clinicians in management of COVID-19 patients and post-COVID-19 effects in them." @default.
• W4313216058 created "2023-01-06" @default.
• W4313216058 creator A5058863845 @default.
• W4313216058 creator A5060039249 @default.
• W4313216058 date "2023-02-01" @default.
• W4313216058 modified "2023-10-16" @default.
• W4313216058 title "In silico transcriptional analysis of asymptomatic and severe COVID-19 patients reveals the susceptibility of severe patients to other comorbidities and non-viral pathological conditions" @default.
• W4313216058 cites W1831050183 @default.
• W4313216058 cites W1943992790 @default.
• W4313216058 cites W1972740244 @default.
• W4313216058 cites W2012034410 @default.
• W4313216058 cites W2021442163 @default.
• W4313216058 cites W2028082228 @default.
• W4313216058 cites W2044086145 @default.
• W4313216058 cites W2069411071 @default.
• W4313216058 cites W2070050178 @default.
• W4313216058 cites W2076646346 @default.
• W4313216058 cites W2098037373 @default.
• W4313216058 cites W2124356353 @default.
• W4313216058 cites W2151070032 @default.
• W4313216058 cites W2153349010 @default.
• W4313216058 cites W2162029527 @default.
• W4313216058 cites W2164013535 @default.
• W4313216058 cites W2167384912 @default.
• W4313216058 cites W2179438025 @default.
• W4313216058 cites W2210192368 @default.
• W4313216058 cites W2294277978 @default.
• W4313216058 cites W2345356016 @default.
• W4313216058 cites W2350873520 @default.
• W4313216058 cites W2474747771 @default.
• W4313216058 cites W2725171488 @default.
• W4313216058 cites W2898105804 @default.
• W4313216058 cites W2901900409 @default.
• W4313216058 cites W2926184778 @default.
• W4313216058 cites W2950221693 @default.
• W4313216058 cites W2971441893 @default.
• W4313216058 cites W2980487636 @default.
• W4313216058 cites W2983485493 @default.
• W4313216058 cites W2991460539 @default.
• W4313216058 cites W3000834295 @default.
• W4313216058 cites W3001118548 @default.
• W4313216058 cites W3002108456 @default.
• W4313216058 cites W3004280078 @default.
• W4313216058 cites W3004951004 @default.
• W4313216058 cites W3005473082 @default.
• W4313216058 cites W3008394341 @default.
• W4313216058 cites W3008874180 @default.
• W4313216058 cites W3009647628 @default.
• W4313216058 cites W3009906937 @default.
• W4313216058 cites W3009912996 @default.
• W4313216058 cites W3011483298 @default.
• W4313216058 cites W3011610993 @default.
• W4313216058 cites W3012099172 @default.
• W4313216058 cites W3012546754 @default.
• W4313216058 cites W3012849736 @default.
• W4313216058 cites W3016701329 @default.
• W4313216058 cites W3016732209 @default.
• W4313216058 cites W3016808868 @default.
• W4313216058 cites W3017022286 @default.
• W4313216058 cites W3017324358 @default.
• W4313216058 cites W3017730472 @default.
• W4313216058 cites W3017841804 @default.
• W4313216058 cites W3019009908 @default.
• W4313216058 cites W3020909574 @default.
• W4313216058 cites W3021242766 @default.
• W4313216058 cites W3021752477 @default.
• W4313216058 cites W3023787531 @default.
• W4313216058 cites W3024082351 @default.
• W4313216058 cites W3025282583 @default.
• W4313216058 cites W3025283891 @default.
• W4313216058 cites W3028020426 @default.
• W4313216058 cites W3029084050 @default.
• W4313216058 cites W3031095594 @default.
• W4313216058 cites W3031341718 @default.
• W4313216058 cites W3034529698 @default.
• W4313216058 cites W3035898754 @default.
• W4313216058 cites W3037899818 @default.
• W4313216058 cites W3041493976 @default.
• W4313216058 cites W3046463683 @default.
• W4313216058 cites W3046790002 @default.
• W4313216058 cites W3050516004 @default.
• W4313216058 cites W3079498584 @default.
• W4313216058 cites W3080315899 @default.
• W4313216058 cites W3080864197 @default.
• W4313216058 cites W3087997015 @default.
• W4313216058 cites W3088385564 @default.
• W4313216058 cites W3091999679 @default.
• W4313216058 cites W3092475336 @default.
• W4313216058 cites W3093082373 @default.
• W4313216058 cites W3093305361 @default.
• W4313216058 cites W3094032395 @default.
• W4313216058 cites W3095016916 @default.
• W4313216058 cites W3095294553 @default.
• W4313216058 cites W3096932402 @default.
• W4313216058 cites W3105753785 @default.
• W4313216058 cites W3106947130 @default.
• W4313216058 cites W3110706654 @default.
• W4313216058 cites W3111913977 @default.

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