Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313220425> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W4313220425 endingPage "171" @default.
- W4313220425 startingPage "171" @default.
- W4313220425 abstract "Introduction: Splenic rupture is most commonly due to trauma but can rarely occur spontaneously in diseased spleens. Nontraumatic splenic rupture has an incidence of less than 0.5%. Spontaneous Tumor Lysis Syndrome (TLS) is also a rare oncologic emergency characterized by a massive release of electrolytes as tumor cells lyse often leading to renal failure and malignant arrhythmias. We present a case of tumor lysis syndrome post splenic rupture in a patient with known Chronic Lymphocytic Leukemia (CLL). Description: A 70 year-old-male with recently diagnosed CLL was admitted for syncope and abdominal pain. CT of the abdomen showed a Grade 4 splenic laceration and a 8.5cm mesenteric soft tissue mass. Labs were remarkable for leukocytosis 588k/μL, pseudohyperkalemia 9.5mmol/L, creatinine 2.21mg/dl, uric acid 21.4mg/dl and phosphorous 4.7mg/dl. The patient was admitted to ICU and underwent an emergent splenectomy for splenic rupture. Due to high suspicion for TLS, rasburicase and allopurinol were initiated and hyperkalemia was treated with insulin, glucose and calcium gluconate. Splenic biopsy showed CLL with Richter’s transformation to diffuse large B cell lymphoma (DLBCL). Spleen was 17cm long and weighed 888g. Postoperatively, chemotherapy was initiated and the patient required dialysis for anuria. Repeat CT abdomen and pelvis after a few weeks showed improved lymphomatous disease. Patient was subsequently taken off dialysis in 2 weeks and successfully discharged from the hospital 2 months later. Discussion: DLBCL is an uncommon etiology of non-traumatic splenic rupture with only a few case reports documented. In isolation, splenic rupture carries a significant mortality rate. To prevent risk of rupture, prophylactic splenectomy is often performed in large, diseased spleens (> 1kg) but in our case spontaneous splenic rupture occurred before the detection of splenomegaly. Tumor lysis syndrome further complicated this particular presentation and resuscitation. Successful management of TLS required a high index of suspicion, aggressive hydration, rasburicase, allopurinol, urinary alkalinization and dialysis. It is unclear as to whether the splenic rupture triggered this event but nonetheless, early recognition, prompt treatment and multidisciplinary team approach was crucial for a successful outcome." @default.
- W4313220425 created "2023-01-06" @default.
- W4313220425 creator A5017062450 @default.
- W4313220425 creator A5055957835 @default.
- W4313220425 date "2022-12-15" @default.
- W4313220425 modified "2023-09-25" @default.
- W4313220425 title "370: TUMOR LYSIS SYNDROME POST-SPLENIC RUPTURE: DOUBLE TROUBLE!" @default.
- W4313220425 doi "https://doi.org/10.1097/01.ccm.0000907208.65660.93" @default.
- W4313220425 hasPublicationYear "2022" @default.
- W4313220425 type Work @default.
- W4313220425 citedByCount "0" @default.
- W4313220425 crossrefType "journal-article" @default.
- W4313220425 hasAuthorship W4313220425A5017062450 @default.
- W4313220425 hasAuthorship W4313220425A5055957835 @default.
- W4313220425 hasBestOaLocation W43132204251 @default.
- W4313220425 hasConcept C126322002 @default.
- W4313220425 hasConcept C141071460 @default.
- W4313220425 hasConcept C2776036575 @default.
- W4313220425 hasConcept C2776309230 @default.
- W4313220425 hasConcept C2776422910 @default.
- W4313220425 hasConcept C2776694085 @default.
- W4313220425 hasConcept C2778653478 @default.
- W4313220425 hasConcept C2778923028 @default.
- W4313220425 hasConcept C2779788671 @default.
- W4313220425 hasConcept C2779978075 @default.
- W4313220425 hasConcept C2780243291 @default.
- W4313220425 hasConcept C2780931953 @default.
- W4313220425 hasConcept C2780955771 @default.
- W4313220425 hasConcept C71924100 @default.
- W4313220425 hasConcept C90924648 @default.
- W4313220425 hasConceptScore W4313220425C126322002 @default.
- W4313220425 hasConceptScore W4313220425C141071460 @default.
- W4313220425 hasConceptScore W4313220425C2776036575 @default.
- W4313220425 hasConceptScore W4313220425C2776309230 @default.
- W4313220425 hasConceptScore W4313220425C2776422910 @default.
- W4313220425 hasConceptScore W4313220425C2776694085 @default.
- W4313220425 hasConceptScore W4313220425C2778653478 @default.
- W4313220425 hasConceptScore W4313220425C2778923028 @default.
- W4313220425 hasConceptScore W4313220425C2779788671 @default.
- W4313220425 hasConceptScore W4313220425C2779978075 @default.
- W4313220425 hasConceptScore W4313220425C2780243291 @default.
- W4313220425 hasConceptScore W4313220425C2780931953 @default.
- W4313220425 hasConceptScore W4313220425C2780955771 @default.
- W4313220425 hasConceptScore W4313220425C71924100 @default.
- W4313220425 hasConceptScore W4313220425C90924648 @default.
- W4313220425 hasIssue "1" @default.
- W4313220425 hasLocation W43132204251 @default.
- W4313220425 hasLocation W43132204252 @default.
- W4313220425 hasOpenAccess W4313220425 @default.
- W4313220425 hasPrimaryLocation W43132204251 @default.
- W4313220425 hasRelatedWork W1527908610 @default.
- W4313220425 hasRelatedWork W2281205375 @default.
- W4313220425 hasRelatedWork W2413637478 @default.
- W4313220425 hasRelatedWork W2806210735 @default.
- W4313220425 hasRelatedWork W2913961725 @default.
- W4313220425 hasRelatedWork W2991595946 @default.
- W4313220425 hasRelatedWork W3047826599 @default.
- W4313220425 hasRelatedWork W3049563099 @default.
- W4313220425 hasRelatedWork W4224270322 @default.
- W4313220425 hasRelatedWork W4245424975 @default.
- W4313220425 hasVolume "51" @default.
- W4313220425 isParatext "false" @default.
- W4313220425 isRetracted "false" @default.
- W4313220425 workType "article" @default.