FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313220431> ?p ?o ?g. }

• W4313220431 abstract "Abstract Mitochondrial cristae host the respiratory chain complexes composed of mitochondrial DNA (mtDNA)-encoded and nuclear-encoded proteins and are responsible for ATP production. Movement of mtDNA located in the matrix is limited due to blockade by the cristae; yet, the dynamic interaction between the inner membrane and mtDNA remains unknown due to the insufficient spatiotemporal resolution of conventional microscopy and the lack of appropriate in vivo probes targeted to the mitochondrial inner membrane. Here, we developed a novel fluorescence probe to visualize the inner membrane using low-power stimulated emission depletion (STED) microscopy. Dual-color imaging of the inner membrane and mtDNA demonstrated that mtDNA is more likely to spread at mitochondrial tips or branch points under an overall even distribution. Interestingly, exploration of forming this distribution propensity uncovered that the mitochondrial dynamics are closely related to the location of mtDNA, and further insight found that fusion always occurs near mtDNA in order to minimize the pressure for cristae remodeling. In healthy cells, mitochondrial dynamics based on cristae remodeling promotes the even distribution of mtDNA, on the contrary, when cristae structure fails in apoptosis and ferroptosis, leading to mtDNA distribution disorder. Observation of active changes during apoptosis further captured the dynamic process of inner membrane herniation and mtDNA leakage along with cristae remodeling. Under ferroptosis, the mitochondria shrank into ellipsoids and mtDNA converged at the center of mitochondria. The rich dynamics between the cristae and mtDNA, revealed at unprecedented spatiotemporal resolution, show the motive and outgrowth of mtDNA distribution." @default.
• W4313220431 created "2023-01-06" @default.
• W4313220431 creator A5013355381 @default.
• W4313220431 creator A5015317056 @default.
• W4313220431 creator A5025442343 @default.
• W4313220431 creator A5038781370 @default.
• W4313220431 creator A5053868737 @default.
• W4313220431 creator A5080870353 @default.
• W4313220431 creator A5086958314 @default.
• W4313220431 date "2022-12-26" @default.
• W4313220431 modified "2023-09-24" @default.
• W4313220431 title "Visualization of mitochondrial cristae and mtDNA evolvement and interactions with super-resolution microscopy" @default.
• W4313220431 cites W1107208185 @default.
• W4313220431 cites W1480391127 @default.
• W4313220431 cites W1969709153 @default.
• W4313220431 cites W1990171977 @default.
• W4313220431 cites W1997183854 @default.
• W4313220431 cites W2003623858 @default.
• W4313220431 cites W2010802040 @default.
• W4313220431 cites W2013091489 @default.
• W4313220431 cites W2014041206 @default.
• W4313220431 cites W2027014236 @default.
• W4313220431 cites W2033275867 @default.
• W4313220431 cites W2039907011 @default.
• W4313220431 cites W2044301214 @default.
• W4313220431 cites W2057695252 @default.
• W4313220431 cites W2058612331 @default.
• W4313220431 cites W2069621851 @default.
• W4313220431 cites W2128417824 @default.
• W4313220431 cites W2130893307 @default.
• W4313220431 cites W2139636031 @default.
• W4313220431 cites W2157334943 @default.
• W4313220431 cites W2162006879 @default.
• W4313220431 cites W2167057359 @default.
• W4313220431 cites W2269880005 @default.
• W4313220431 cites W2288456204 @default.
• W4313220431 cites W2465187827 @default.
• W4313220431 cites W2524977785 @default.
• W4313220431 cites W2617289122 @default.
• W4313220431 cites W2780529771 @default.
• W4313220431 cites W2788480107 @default.
• W4313220431 cites W2809281987 @default.
• W4313220431 cites W2892240583 @default.
• W4313220431 cites W2906319220 @default.
• W4313220431 cites W2914746958 @default.
• W4313220431 cites W2941806757 @default.
• W4313220431 cites W2948618629 @default.
• W4313220431 cites W2951620702 @default.
• W4313220431 cites W2959317056 @default.
• W4313220431 cites W2963517700 @default.
• W4313220431 cites W2970904481 @default.
• W4313220431 cites W2980622391 @default.
• W4313220431 cites W3008032023 @default.
• W4313220431 cites W3011194921 @default.
• W4313220431 cites W3016982046 @default.
• W4313220431 cites W3033665025 @default.
• W4313220431 cites W3044756023 @default.
• W4313220431 cites W3081113883 @default.
• W4313220431 cites W3081196248 @default.
• W4313220431 cites W3084214356 @default.
• W4313220431 cites W3126069796 @default.
• W4313220431 cites W4309135074 @default.
• W4313220431 cites W4313452448 @default.
• W4313220431 cites W4376848339 @default.
• W4313220431 doi "https://doi.org/10.1101/2022.12.26.521907" @default.
• W4313220431 hasPublicationYear "2022" @default.
• W4313220431 type Work @default.
• W4313220431 citedByCount "1" @default.
• W4313220431 countsByYear W43132204312023 @default.
• W4313220431 crossrefType "posted-content" @default.
• W4313220431 hasAuthorship W4313220431A5013355381 @default.
• W4313220431 hasAuthorship W4313220431A5015317056 @default.
• W4313220431 hasAuthorship W4313220431A5025442343 @default.
• W4313220431 hasAuthorship W4313220431A5038781370 @default.
• W4313220431 hasAuthorship W4313220431A5053868737 @default.
• W4313220431 hasAuthorship W4313220431A5080870353 @default.
• W4313220431 hasAuthorship W4313220431A5086958314 @default.
• W4313220431 hasBestOaLocation W43132204311 @default.
• W4313220431 hasConcept C104317684 @default.
• W4313220431 hasConcept C11701378 @default.
• W4313220431 hasConcept C12554922 @default.
• W4313220431 hasConcept C146587185 @default.
• W4313220431 hasConcept C163950672 @default.
• W4313220431 hasConcept C173358068 @default.
• W4313220431 hasConcept C181199279 @default.
• W4313220431 hasConcept C24586158 @default.
• W4313220431 hasConcept C28859421 @default.
• W4313220431 hasConcept C54355233 @default.
• W4313220431 hasConcept C547475151 @default.
• W4313220431 hasConcept C55493867 @default.
• W4313220431 hasConcept C65871279 @default.
• W4313220431 hasConcept C75385678 @default.
• W4313220431 hasConcept C86803240 @default.
• W4313220431 hasConcept C95444343 @default.
• W4313220431 hasConcept C98539663 @default.
• W4313220431 hasConceptScore W4313220431C104317684 @default.
• W4313220431 hasConceptScore W4313220431C11701378 @default.
• W4313220431 hasConceptScore W4313220431C12554922 @default.
• W4313220431 hasConceptScore W4313220431C146587185 @default.
• W4313220431 hasConceptScore W4313220431C163950672 @default.

• next