FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313220650> ?p ?o ?g. }

• W4313220650 endingPage "461" @default.
• W4313220650 startingPage "461" @default.
• W4313220650 abstract "Introduction: The data supporting an appropriate duration of antibiotic treatment for ventilator-associated pneumonia (VAP) is limited. Current guidelines still recommend short-duration antibiotic therapy for non-fermenting gram-negative bacilli (NF-GNB) VAP which may be associated with a higher recurrence of pneumonia. In this meta-analysis, we aimed to address this knowledge gap and compare the outcomes of randomized controlled trials (RCTs) of short- versus prolonged-course antibiotic regimens for VAP. Methods: We searched the Cochrane Library, PubMed, and Embase databases from their inception till June 2022 (PROSPERO CRD42022340615). We included RCTs that compared the effectiveness of a “short” versus “prolonged” course of antibiotic treatment in patients with VAP. Our primary outcomes were 28-day mortality and recurrence of pneumonia. Data analysis was performed using RevMan 5.4. Risk ratios (RRs) and mean differences (MDs) were calculated as effect measures. Results: Our pooled analysis consisted of six RCTs. For 28-day mortality, no significant difference was found between the prolonged course and the short course (RR 1.15; 95% CI: 0.86-1.52). Administration of a short course of antibiotics increased the risk of recurrence of pneumonia (RR 1.34; 95% CI: 1.02-1.75); however, in sensitivity analyses, when including trials published as full-length articles, trials using 8- versus 15-day regimens only, and trials using the same antibiotics in both arms only, the results became non-significant. Secondary outcomes, such as clinical resolution, duration of intensive care unit (ICU) stay, duration of mechanical ventilation, mechanical ventilation free days, and mortality at the latest reported time revealed no significant difference between the two regimens. The short course was, however, associated with a greater number of antibiotic-free days (MD 4.02; 95% CI: 2.26-5.78). Conclusions: Our meta-analysis showed that a short course of antibiotics was associated with a higher recurrence of pneumonia but more antibiotic-free days with no difference in mortality risk as compared to a prolonged course. The decision about the length of a regimen should be based on close biological and clinical monitoring taking into account relevant patient factors and the resource setting." @default.
• W4313220650 created "2023-01-06" @default.
• W4313220650 creator A5009577840 @default.
• W4313220650 creator A5038767026 @default.
• W4313220650 creator A5039414475 @default.
• W4313220650 creator A5050273442 @default.
• W4313220650 creator A5052625012 @default.
• W4313220650 creator A5075403860 @default.
• W4313220650 creator A5076413503 @default.
• W4313220650 creator A5091475681 @default.
• W4313220650 date "2022-12-15" @default.
• W4313220650 modified "2023-10-16" @default.
• W4313220650 title "937: SHORT VERSUS PROLONGED COURSE OF ANTIBIOTICS FOR VENTILATOR-ASSOCIATED PNEUMONIA: A META-ANALYSIS" @default.
• W4313220650 doi "https://doi.org/10.1097/01.ccm.0000909476.05026.c3" @default.
• W4313220650 hasPublicationYear "2022" @default.
• W4313220650 type Work @default.
• W4313220650 citedByCount "0" @default.
• W4313220650 crossrefType "journal-article" @default.
• W4313220650 hasAuthorship W4313220650A5009577840 @default.
• W4313220650 hasAuthorship W4313220650A5038767026 @default.
• W4313220650 hasAuthorship W4313220650A5039414475 @default.
• W4313220650 hasAuthorship W4313220650A5050273442 @default.
• W4313220650 hasAuthorship W4313220650A5052625012 @default.
• W4313220650 hasAuthorship W4313220650A5075403860 @default.
• W4313220650 hasAuthorship W4313220650A5076413503 @default.
• W4313220650 hasAuthorship W4313220650A5091475681 @default.
• W4313220650 hasBestOaLocation W43132206501 @default.
• W4313220650 hasConcept C126322002 @default.
• W4313220650 hasConcept C168563851 @default.
• W4313220650 hasConcept C177713679 @default.
• W4313220650 hasConcept C2776376669 @default.
• W4313220650 hasConcept C2776478404 @default.
• W4313220650 hasConcept C2777080012 @default.
• W4313220650 hasConcept C2777184939 @default.
• W4313220650 hasConcept C2777914695 @default.
• W4313220650 hasConcept C44249647 @default.
• W4313220650 hasConcept C501593827 @default.
• W4313220650 hasConcept C71924100 @default.
• W4313220650 hasConcept C82789193 @default.
• W4313220650 hasConcept C86803240 @default.
• W4313220650 hasConcept C89423630 @default.
• W4313220650 hasConcept C95190672 @default.
• W4313220650 hasConceptScore W4313220650C126322002 @default.
• W4313220650 hasConceptScore W4313220650C168563851 @default.
• W4313220650 hasConceptScore W4313220650C177713679 @default.
• W4313220650 hasConceptScore W4313220650C2776376669 @default.
• W4313220650 hasConceptScore W4313220650C2776478404 @default.
• W4313220650 hasConceptScore W4313220650C2777080012 @default.
• W4313220650 hasConceptScore W4313220650C2777184939 @default.
• W4313220650 hasConceptScore W4313220650C2777914695 @default.
• W4313220650 hasConceptScore W4313220650C44249647 @default.
• W4313220650 hasConceptScore W4313220650C501593827 @default.
• W4313220650 hasConceptScore W4313220650C71924100 @default.
• W4313220650 hasConceptScore W4313220650C82789193 @default.
• W4313220650 hasConceptScore W4313220650C86803240 @default.
• W4313220650 hasConceptScore W4313220650C89423630 @default.
• W4313220650 hasConceptScore W4313220650C95190672 @default.
• W4313220650 hasIssue "1" @default.
• W4313220650 hasLocation W43132206501 @default.
• W4313220650 hasLocation W43132206502 @default.
• W4313220650 hasOpenAccess W4313220650 @default.
• W4313220650 hasPrimaryLocation W43132206501 @default.
• W4313220650 hasRelatedWork W1651394837 @default.
• W4313220650 hasRelatedWork W2009263326 @default.
• W4313220650 hasRelatedWork W2041740107 @default.
• W4313220650 hasRelatedWork W2068150602 @default.
• W4313220650 hasRelatedWork W2133776215 @default.
• W4313220650 hasRelatedWork W2138470825 @default.
• W4313220650 hasRelatedWork W2327755418 @default.
• W4313220650 hasRelatedWork W2379207176 @default.
• W4313220650 hasRelatedWork W3032635361 @default.
• W4313220650 hasRelatedWork W81407855 @default.
• W4313220650 hasVolume "51" @default.
• W4313220650 isParatext "false" @default.
• W4313220650 isRetracted "false" @default.
• W4313220650 workType "article" @default.