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• W4313221244 abstract "Endothelial cell (EC) coupling occurs through gap junctions and underlies cerebral blood flow regulation governed by inward-rectifying K+ (KIR ) channels. This study addressed effects of KIR channel activity on EC coupling before and during Alzheimer's disease (AD).Intact EC tubes (width: ~90-100 μm; length: ~0.5 mm) were freshly isolated from posterior cerebral arteries of young Pre-AD (1-3 months) and aged AD (13-18 months) male and female 3xTg-AD mice. Dual intracellular microelectrodes applied simultaneous current injections (±0.5-3 nA) and membrane potential (Vm ) recordings in ECs at distance ~400 μm. Elevated extracellular potassium ([K+ ]E ; 8-15 mmol/L; reference, 5 mmol/L) activated KIR channels.Conducted Vm (∆Vm ) responses ranged from ~-30 to 30 mV in response to -3 to +3 nA (linear regression, R2 ≥ .99) while lacking rectification for charge polarity or axial direction of spread. Conduction slope decreased ~10%-20% during 15 mmol/L [K+ ]E in Pre-AD males and AD females. 15 mmol/L [K+ ]E decreased conduction by ~10%-20% at lower ∆Vm thresholds in AD animals (~±20 mV) versus Pre-AD (~±25 mV). AD increased conducted hyperpolarization by ~10%-15% during 8-12 mmol/L [K+ ]E .Brain endothelial KIR channel activity modulates bidirectional spread of vasoreactive signals with enhanced regulation of EC coupling during AD pathology." @default.
• W4313221244 created "2023-01-06" @default.
• W4313221244 creator A5077275817 @default.
• W4313221244 creator A5080221163 @default.
• W4313221244 date "2023-01-01" @default.
• W4313221244 modified "2023-10-16" @default.
• W4313221244 title "K _IR channel regulation of electrical conduction along cerebrovascular endothelium: Enhanced modulation during Alzheimer's disease" @default.
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• W4313221244 doi "https://doi.org/10.1111/micc.12797" @default.
• W4313221244 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36577656" @default.
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