FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313224256> ?p ?o ?g. }

• W4313224256 endingPage "12" @default.
• W4313224256 startingPage "1" @default.
• W4313224256 abstract "Objective. This study is aimed at exploring the molecular mechanism of Shufeiya recipe in the treatment of pulmonary hypertension (PH) using network pharmacology and molecular docking analysis. Methods. Active components and their target proteins in the recipe were screened using the TCMSP database. PH-related core proteins were screened using GeneCards, STRING database, and Cytoscape-v3.8.2. Common proteins were obtained by intersection of the target proteins of these recipe active components and pH-related core proteins. Rx64 4.0.2 software was used to perform GO functional enrichment analysis and KEGG pathway enrichment analysis on the common proteins to obtain pathway-enriched proteins, and then core enriched proteins were further screened. We analyzed the relationship between the active components and pathway-enriched proteins using Cytoscape-v3.8.2. AutoDock Vina was used to dock their core proteins into the components. Results. Shufeiya recipe contained 67 active components. 61 common proteins of the target proteins of the active components and PH-related core proteins were obtained. The treatment involved both functional and pathway regulations. The core pathway-enriched proteins were prostaglandin G/H synthase 2 (PTGS2), epidermal growth factor receptor (EGFR), and RAC-alpha serine/threonine-protein kinase (AKT1), and their binding energies to the corresponding components were all less than -5 kJ•mol-1. Conclusion. It was found that the main mechanism might be the active components acting on the core pathway-enriched proteins to regulate related signaling pathways, thereby playing roles in anticoagulation, vasodilation, anti-PASMC proliferation, promotion of PAECs apoptosis, inhibition of oxidative stress, and anti-inflammatory effects." @default.
• W4313224256 created "2023-01-06" @default.
• W4313224256 creator A5006927743 @default.
• W4313224256 creator A5051350415 @default.
• W4313224256 creator A5061995701 @default.
• W4313224256 creator A5077081961 @default.
• W4313224256 creator A5080657992 @default.
• W4313224256 date "2022-12-28" @default.
• W4313224256 modified "2023-10-05" @default.
• W4313224256 title "Network Pharmacology and Molecular Docking Analysis of Shufeiya Recipe in the Treatment of Pulmonary Hypertension" @default.
• W4313224256 cites W1987208980 @default.
• W4313224256 cites W2010294336 @default.
• W4313224256 cites W2035731051 @default.
• W4313224256 cites W2043950247 @default.
• W4313224256 cites W2119657089 @default.
• W4313224256 cites W2124679671 @default.
• W4313224256 cites W2131264643 @default.
• W4313224256 cites W2133071999 @default.
• W4313224256 cites W2167856198 @default.
• W4313224256 cites W2169272043 @default.
• W4313224256 cites W2262667854 @default.
• W4313224256 cites W2293750515 @default.
• W4313224256 cites W2405536997 @default.
• W4313224256 cites W2559588208 @default.
• W4313224256 cites W2559974546 @default.
• W4313224256 cites W2615742986 @default.
• W4313224256 cites W2620998958 @default.
• W4313224256 cites W2754132491 @default.
• W4313224256 cites W2771034046 @default.
• W4313224256 cites W2793677164 @default.
• W4313224256 cites W2890682818 @default.
• W4313224256 cites W2890764600 @default.
• W4313224256 cites W2965216369 @default.
• W4313224256 cites W2970534831 @default.
• W4313224256 cites W2996734298 @default.
• W4313224256 cites W3012489042 @default.
• W4313224256 cites W3041861047 @default.
• W4313224256 cites W3083702334 @default.
• W4313224256 cites W3094142105 @default.
• W4313224256 cites W3097145107 @default.
• W4313224256 cites W3107527779 @default.
• W4313224256 cites W3112376646 @default.
• W4313224256 cites W3119104706 @default.
• W4313224256 cites W3135817634 @default.
• W4313224256 cites W3153216759 @default.
• W4313224256 cites W4205424893 @default.
• W4313224256 cites W4213062887 @default.
• W4313224256 doi "https://doi.org/10.1155/2022/7864976" @default.
• W4313224256 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36756383" @default.
• W4313224256 hasPublicationYear "2022" @default.
• W4313224256 type Work @default.
• W4313224256 citedByCount "4" @default.
• W4313224256 countsByYear W43132242562023 @default.
• W4313224256 crossrefType "journal-article" @default.
• W4313224256 hasAuthorship W4313224256A5006927743 @default.
• W4313224256 hasAuthorship W4313224256A5051350415 @default.
• W4313224256 hasAuthorship W4313224256A5061995701 @default.
• W4313224256 hasAuthorship W4313224256A5077081961 @default.
• W4313224256 hasAuthorship W4313224256A5080657992 @default.
• W4313224256 hasBestOaLocation W43132242561 @default.
• W4313224256 hasConcept C104317684 @default.
• W4313224256 hasConcept C11960822 @default.
• W4313224256 hasConcept C150194340 @default.
• W4313224256 hasConcept C152724338 @default.
• W4313224256 hasConcept C154137905 @default.
• W4313224256 hasConcept C159110408 @default.
• W4313224256 hasConcept C162317418 @default.
• W4313224256 hasConcept C185592680 @default.
• W4313224256 hasConcept C2775905019 @default.
• W4313224256 hasConcept C2776414213 @default.
• W4313224256 hasConcept C2780152424 @default.
• W4313224256 hasConcept C41685203 @default.
• W4313224256 hasConcept C55493867 @default.
• W4313224256 hasConcept C62478195 @default.
• W4313224256 hasConcept C70721500 @default.
• W4313224256 hasConcept C71924100 @default.
• W4313224256 hasConcept C86554907 @default.
• W4313224256 hasConcept C86803240 @default.
• W4313224256 hasConceptScore W4313224256C104317684 @default.
• W4313224256 hasConceptScore W4313224256C11960822 @default.
• W4313224256 hasConceptScore W4313224256C150194340 @default.
• W4313224256 hasConceptScore W4313224256C152724338 @default.
• W4313224256 hasConceptScore W4313224256C154137905 @default.
• W4313224256 hasConceptScore W4313224256C159110408 @default.
• W4313224256 hasConceptScore W4313224256C162317418 @default.
• W4313224256 hasConceptScore W4313224256C185592680 @default.
• W4313224256 hasConceptScore W4313224256C2775905019 @default.
• W4313224256 hasConceptScore W4313224256C2776414213 @default.
• W4313224256 hasConceptScore W4313224256C2780152424 @default.
• W4313224256 hasConceptScore W4313224256C41685203 @default.
• W4313224256 hasConceptScore W4313224256C55493867 @default.
• W4313224256 hasConceptScore W4313224256C62478195 @default.
• W4313224256 hasConceptScore W4313224256C70721500 @default.
• W4313224256 hasConceptScore W4313224256C71924100 @default.
• W4313224256 hasConceptScore W4313224256C86554907 @default.
• W4313224256 hasConceptScore W4313224256C86803240 @default.
• W4313224256 hasFunder F4320321106 @default.
• W4313224256 hasLocation W43132242561 @default.

• next