Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313225630> ?p ?o ?g. }
- W4313225630 endingPage "2804" @default.
- W4313225630 startingPage "2790" @default.
- W4313225630 abstract "Abstract Background Glial fibrillary acidic protein (GFAP) is a promising candidate blood‐based biomarker for Alzheimer's disease (AD) diagnosis and prognostication. The timing of its disease‐associated changes, its clinical correlates, and biofluid‐type dependency will influence its clinical utility. Methods We evaluated plasma, serum, and cerebrospinal fluid (CSF) GFAP in families with autosomal dominant AD (ADAD), leveraging the predictable age at symptom onset to determine changes by stage of disease. Results Plasma GFAP elevations appear a decade before expected symptom onset, after amyloid beta (Aβ) accumulation and prior to neurodegeneration and cognitive decline. Plasma GFAP distinguished Aβ‐positive from Aβ‐negative ADAD participants and showed a stronger relationship with Aβ load in asymptomatic than symptomatic ADAD. Higher plasma GFAP was associated with the degree and rate of neurodegeneration and cognitive impairment. Serum GFAP showed similar relationships, but these were less pronounced for CSF GFAP. Conclusion Our findings support a role for plasma GFAP as a clinical biomarker of Aβ‐related astrocyte reactivity that is associated with cognitive decline and neurodegeneration. Highlights Plasma glial fibrillary acidic protein (GFAP) elevations appear a decade before expected symptom onset in autosomal dominant Alzheimer's disease (ADAD). Plasma GFAP was associated to amyloid positivity in asymptomatic ADAD. Plasma GFAP increased with clinical severity and predicted disease progression. Plasma and serum GFAP carried similar information in ADAD, while cerebrospinal fluid GFAP did not." @default.
- W4313225630 created "2023-01-06" @default.
- W4313225630 creator A5000597778 @default.
- W4313225630 creator A5004179995 @default.
- W4313225630 creator A5006902532 @default.
- W4313225630 creator A5008695173 @default.
- W4313225630 creator A5010166794 @default.
- W4313225630 creator A5010409175 @default.
- W4313225630 creator A5010912426 @default.
- W4313225630 creator A5018836358 @default.
- W4313225630 creator A5022462599 @default.
- W4313225630 creator A5023920651 @default.
- W4313225630 creator A5025837253 @default.
- W4313225630 creator A5026336275 @default.
- W4313225630 creator A5028606995 @default.
- W4313225630 creator A5035514608 @default.
- W4313225630 creator A5037223246 @default.
- W4313225630 creator A5038805449 @default.
- W4313225630 creator A5039975345 @default.
- W4313225630 creator A5040490170 @default.
- W4313225630 creator A5042878654 @default.
- W4313225630 creator A5047208165 @default.
- W4313225630 creator A5047385288 @default.
- W4313225630 creator A5048987900 @default.
- W4313225630 creator A5051680529 @default.
- W4313225630 creator A5052660860 @default.
- W4313225630 creator A5062159344 @default.
- W4313225630 creator A5063381985 @default.
- W4313225630 creator A5065618928 @default.
- W4313225630 creator A5068373508 @default.
- W4313225630 creator A5069735960 @default.
- W4313225630 creator A5070531237 @default.
- W4313225630 creator A5071364728 @default.
- W4313225630 creator A5075394738 @default.
- W4313225630 creator A5076227792 @default.
- W4313225630 creator A5084033552 @default.
- W4313225630 creator A5088915384 @default.
- W4313225630 creator A5090202716 @default.
- W4313225630 creator A5090741969 @default.
- W4313225630 creator A5091046259 @default.
- W4313225630 date "2022-12-28" @default.
- W4313225630 modified "2023-10-11" @default.
- W4313225630 title "Plasma glial fibrillary acidic protein in autosomal dominant Alzheimer's disease: Associations with Aβ‐PET, neurodegeneration, and cognition" @default.
- W4313225630 cites W1509113153 @default.
- W4313225630 cites W1552917344 @default.
- W4313225630 cites W1847168837 @default.
- W4313225630 cites W1965252410 @default.
- W4313225630 cites W1966936071 @default.
- W4313225630 cites W1977541817 @default.
- W4313225630 cites W1991952617 @default.
- W4313225630 cites W2003421378 @default.
- W4313225630 cites W2013999013 @default.
- W4313225630 cites W2026415168 @default.
- W4313225630 cites W2032220418 @default.
- W4313225630 cites W2068951793 @default.
- W4313225630 cites W2087243986 @default.
- W4313225630 cites W2091850201 @default.
- W4313225630 cites W2096978860 @default.
- W4313225630 cites W2129567809 @default.
- W4313225630 cites W2134303321 @default.
- W4313225630 cites W2144021643 @default.
- W4313225630 cites W2151889964 @default.
- W4313225630 cites W2154780300 @default.
- W4313225630 cites W2157816812 @default.
- W4313225630 cites W2171250577 @default.
- W4313225630 cites W2171502370 @default.
- W4313225630 cites W2196268942 @default.
- W4313225630 cites W2238733797 @default.
- W4313225630 cites W2276853091 @default.
- W4313225630 cites W2510233326 @default.
- W4313225630 cites W2572710398 @default.
- W4313225630 cites W2786513893 @default.
- W4313225630 cites W2787666045 @default.
- W4313225630 cites W2791662659 @default.
- W4313225630 cites W2801244110 @default.
- W4313225630 cites W2910313823 @default.
- W4313225630 cites W2910535142 @default.
- W4313225630 cites W2925266449 @default.
- W4313225630 cites W2969413450 @default.
- W4313225630 cites W2969998884 @default.
- W4313225630 cites W2976163884 @default.
- W4313225630 cites W3012272172 @default.
- W4313225630 cites W3015907136 @default.
- W4313225630 cites W3015916968 @default.
- W4313225630 cites W3018541302 @default.
- W4313225630 cites W3032786132 @default.
- W4313225630 cites W3037038790 @default.
- W4313225630 cites W3049747840 @default.
- W4313225630 cites W3088634533 @default.
- W4313225630 cites W3088667180 @default.
- W4313225630 cites W3108081750 @default.
- W4313225630 cites W3122367423 @default.
- W4313225630 cites W3123207203 @default.
- W4313225630 cites W3132240972 @default.
- W4313225630 cites W3152459827 @default.
- W4313225630 cites W3153444802 @default.
- W4313225630 cites W3158280019 @default.
- W4313225630 cites W3160209782 @default.