FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313226502> ?p ?o ?g. }

• W4313226502 endingPage "38" @default.
• W4313226502 startingPage "37" @default.
• W4313226502 abstract "There remains an essential need for more novel insights into the diagnosis of acral melanoma. Moreover, making a differential diagnosis between benign nevus and intermediate malignancies is crucial. This article is very timely as it describes the efficacy of PReferentially expressed Antigen in MElanoma (PRAME) antibody for the diagnosis of acral melanoma. Acral melanomas have a poor prognosis and predominantly occur among Asian populations. As the role of PRAME immunohistochemistry in the diagnosis of acral melanomas has not been thoroughly investigated, this article provides a better understanding of the efficacy of PRAME in acral melanoma diagnosis compared with the use of mitogen-activated protein kinase signaling molecules including c-Kit, c-Myc, and cyclin D1 in melanoma. Differentiating benign from malignant melanocytic proliferations is very important, and this newly provided marker PRAME may be promising in making such differentiation.1 PRAME has been reportedly expressed in cutaneous and ocular melanomas.2 Moreover, it has been shown that PRAME immunocytochemistry is highly specific for the diagnosis of melanoma metastasis from a cytological sample, although less sensitive than other melanocytic markers.3 PRAME overexpression in tumor tissues versus paired adjacent tissues and its association with poor prognosis of cancer patients have also been well-documented.4 The authors of this article are to be commended for their retrospective evaluation of the diagnostic capability of PRAME immunohistochemistry, as their investigation encompasses acral melanomas and acral superficial atypical melanocytic proliferation of uncertain significance. Equally important is their comparison of the diagnostic ability of PRAME with those of c-Kit, c-Myc, and cyclin D1, which are considered as other potential markers of melanocytic proliferation. The possible comparable capability of PRAME immunohistochemistry in diagnosing melanomas from acral areas compared with melanomas from other sites has also been corroborated by previous studies as reported by the authors. PRAME expression testing has also been described to have the potential to provide useful information for assessing diagnostically ambiguous melanocytic neoplasms.5 A high concordance between PRAME immunohistochemistry and cytogenetic test results has been described in the evaluation of ambiguous primary cutaneous melanocytic neoplasms. This ushers the potential of PRAME immunohistochemistry as an ancillary test, especially that it has the practical advantages of being less expensive and having a faster turnaround than cytogenetic or gene expression studies.5 In concurrence with the authors, the potential for PRAME immunohistochemistry as being a first line ancillary diagnostic test for acral melanocytic proliferation is indeed promising. The inexpensiveness and high concordance rate of PRAME immunohistochemistry with the gold standard histopathological assessments indicate its potential as first line ancillary test for acral melanocytic lesions that are difficult to diagnose. However, as with any diagnostic tests, the authors correctly emphasize that false-negative or false-positive results can also occur. Therefore, conducting combination diagnostic examinations over a lone ancillary test is crucial for a definitive diagnosis of acral melanoma." @default.
• W4313226502 created "2023-01-06" @default.
• W4313226502 creator A5065532602 @default.
• W4313226502 date "2022-12-28" @default.
• W4313226502 modified "2023-10-14" @default.
• W4313226502 title "Editorial Comment on “Performance of PRAME immunohistochemistry compared with that of c‐Kit, c‐Myc, or cyclin D1 for the diagnosis of acral melanocytic tumors”" @default.
• W4313226502 cites W3016766334 @default.
• W4313226502 cites W3121778797 @default.
• W4313226502 cites W4220789965 @default.
• W4313226502 doi "https://doi.org/10.1111/pin.13298" @default.
• W4313226502 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36575944" @default.
• W4313226502 hasPublicationYear "2022" @default.
• W4313226502 type Work @default.
• W4313226502 citedByCount "0" @default.
• W4313226502 crossrefType "journal-article" @default.
• W4313226502 hasAuthorship W4313226502A5065532602 @default.
• W4313226502 hasBestOaLocation W43132265021 @default.
• W4313226502 hasConcept C121608353 @default.
• W4313226502 hasConcept C126322002 @default.
• W4313226502 hasConcept C142724271 @default.
• W4313226502 hasConcept C199835354 @default.
• W4313226502 hasConcept C200583388 @default.
• W4313226502 hasConcept C204232928 @default.
• W4313226502 hasConcept C2777658100 @default.
• W4313226502 hasConcept C2779013556 @default.
• W4313226502 hasConcept C2780801072 @default.
• W4313226502 hasConcept C29537977 @default.
• W4313226502 hasConcept C502942594 @default.
• W4313226502 hasConcept C71924100 @default.
• W4313226502 hasConceptScore W4313226502C121608353 @default.
• W4313226502 hasConceptScore W4313226502C126322002 @default.
• W4313226502 hasConceptScore W4313226502C142724271 @default.
• W4313226502 hasConceptScore W4313226502C199835354 @default.
• W4313226502 hasConceptScore W4313226502C200583388 @default.
• W4313226502 hasConceptScore W4313226502C204232928 @default.
• W4313226502 hasConceptScore W4313226502C2777658100 @default.
• W4313226502 hasConceptScore W4313226502C2779013556 @default.
• W4313226502 hasConceptScore W4313226502C2780801072 @default.
• W4313226502 hasConceptScore W4313226502C29537977 @default.
• W4313226502 hasConceptScore W4313226502C502942594 @default.
• W4313226502 hasConceptScore W4313226502C71924100 @default.
• W4313226502 hasIssue "1" @default.
• W4313226502 hasLocation W43132265021 @default.
• W4313226502 hasLocation W43132265022 @default.
• W4313226502 hasLocation W43132265023 @default.
• W4313226502 hasOpenAccess W4313226502 @default.
• W4313226502 hasPrimaryLocation W43132265021 @default.
• W4313226502 hasRelatedWork W1970083179 @default.
• W4313226502 hasRelatedWork W2144740294 @default.
• W4313226502 hasRelatedWork W2331606468 @default.
• W4313226502 hasRelatedWork W2364973444 @default.
• W4313226502 hasRelatedWork W2371735115 @default.
• W4313226502 hasRelatedWork W2381658428 @default.
• W4313226502 hasRelatedWork W2413189820 @default.
• W4313226502 hasRelatedWork W2623003466 @default.
• W4313226502 hasRelatedWork W3168885310 @default.
• W4313226502 hasRelatedWork W319425533 @default.
• W4313226502 hasVolume "73" @default.
• W4313226502 isParatext "false" @default.
• W4313226502 isRetracted "false" @default.
• W4313226502 workType "editorial" @default.