FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313227595> ?p ?o ?g. }

• W4313227595 endingPage "1376" @default.
• W4313227595 startingPage "1369" @default.
• W4313227595 abstract "Sensitive skin (SS) is a clinical syndrome defined by the occurrence of unpleasant sensations (such as stinging, burning, pain, pruritus, and tingling) in response to stimuli that normally should not provoke them. According to growing evidence, transient receptor potential vanilloid subtype 1 (TRPV1) has elevated expression in individuals with SS and is linked with the severity of SS symptoms. However, its pathogenesis is still unknown.Herein, Citrus reticulata (Tangerine) fruit extract (CR) was obtained and examined for its effect on SS with a focus on TRPV1 stimulation and expression.A recombinant hTRPV1 over-expression cell line (HaCaT-TRPV1-OE cell) was constructed to screen substances and extracts from several plants. Intracellular calcium mobilization was monitored by Flexstation 3 and a fluorescence microscope using Fluo 8 AM fluorophore. Next, immunofluorescence was used to detect the TRPV1 expression under different stimulants treated for 24 h. To investigate the relief and increased tolerance of CR to lactic acid-induced skin discomfort, clinical tests were carried out on the nasolabial folds or cheek areas.According to the obtained results, compared to HaCaT cells, HaCaT-TRPV1-OE cells showed a higher expression of TRPV1. Neuronal hyperresponsiveness in SS triggered by capsaicin (CAP), lactic acid, phenoxyethanol or nicotinamide may be through activation of TRPV1 and increased TRPV1 expression. CAP activates TRPV1 in HaCaT-TRPV1-OE cells, and more than 100 plants or chemicals were tested for their inhibitory effects before being screened for CR. CR (1%-4%) inhibited TRPV1 activation induced by CAP or phenoxyethanol or nicotinamide. Meanwhile, CR (0.25%) suppressed TRPV1 protein expression induced by phenoxyethanol or lactic acid. In vivo results showed that CR not only instantly relieved lactic acid-induced skin discomfort under 5 min but also enhanced skin tolerance to lactic acid after 7 days of continuous use.Topical application of CR showed an instant and long-lasting improvement in SS by modulating the activation and expression of TRPV1. Moreover, it has been suggested that CR might act as a TRPV1 inhibitor to reduce skin irritation or sensitivity." @default.
• W4313227595 created "2023-01-06" @default.
• W4313227595 creator A5017643220 @default.
• W4313227595 creator A5017941291 @default.
• W4313227595 creator A5039932785 @default.
• W4313227595 creator A5067817743 @default.
• W4313227595 creator A5077443898 @default.
• W4313227595 date "2022-12-27" @default.
• W4313227595 modified "2023-10-16" @default.
• W4313227595 title "Modulation of TRPV1 function by <i>Citrus reticulata</i> (tangerine) fruit extract for the treatment of sensitive skin" @default.
• W4313227595 cites W1569805234 @default.
• W4313227595 cites W158997302 @default.
• W4313227595 cites W2045404190 @default.
• W4313227595 cites W2194570164 @default.
• W4313227595 cites W2199052432 @default.
• W4313227595 cites W2295899286 @default.
• W4313227595 cites W2330027807 @default.
• W4313227595 cites W2390258164 @default.
• W4313227595 cites W2740394230 @default.
• W4313227595 cites W2935974918 @default.
• W4313227595 cites W2945252944 @default.
• W4313227595 cites W2988984753 @default.
• W4313227595 cites W2995397880 @default.
• W4313227595 cites W3007035179 @default.
• W4313227595 cites W3045649813 @default.
• W4313227595 cites W3047177116 @default.
• W4313227595 cites W3087515670 @default.
• W4313227595 cites W3105434842 @default.
• W4313227595 cites W3182329901 @default.
• W4313227595 cites W3200416389 @default.
• W4313227595 cites W3206449257 @default.
• W4313227595 cites W4233507545 @default.
• W4313227595 cites W4248704620 @default.
• W4313227595 doi "https://doi.org/10.1111/jocd.15578" @default.
• W4313227595 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36575892" @default.
• W4313227595 hasPublicationYear "2022" @default.
• W4313227595 type Work @default.
• W4313227595 citedByCount "3" @default.
• W4313227595 countsByYear W43132275952023 @default.
• W4313227595 crossrefType "journal-article" @default.
• W4313227595 hasAuthorship W4313227595A5017643220 @default.
• W4313227595 hasAuthorship W4313227595A5017941291 @default.
• W4313227595 hasAuthorship W4313227595A5039932785 @default.
• W4313227595 hasAuthorship W4313227595A5067817743 @default.
• W4313227595 hasAuthorship W4313227595A5077443898 @default.
• W4313227595 hasBestOaLocation W43132275951 @default.
• W4313227595 hasConcept C118995209 @default.
• W4313227595 hasConcept C153911025 @default.
• W4313227595 hasConcept C155164980 @default.
• W4313227595 hasConcept C160145004 @default.
• W4313227595 hasConcept C170493617 @default.
• W4313227595 hasConcept C185592680 @default.
• W4313227595 hasConcept C202751555 @default.
• W4313227595 hasConcept C2777074287 @default.
• W4313227595 hasConcept C2780051329 @default.
• W4313227595 hasConcept C55493867 @default.
• W4313227595 hasConcept C71924100 @default.
• W4313227595 hasConcept C79879829 @default.
• W4313227595 hasConcept C86803240 @default.
• W4313227595 hasConcept C98274493 @default.
• W4313227595 hasConceptScore W4313227595C118995209 @default.
• W4313227595 hasConceptScore W4313227595C153911025 @default.
• W4313227595 hasConceptScore W4313227595C155164980 @default.
• W4313227595 hasConceptScore W4313227595C160145004 @default.
• W4313227595 hasConceptScore W4313227595C170493617 @default.
• W4313227595 hasConceptScore W4313227595C185592680 @default.
• W4313227595 hasConceptScore W4313227595C202751555 @default.
• W4313227595 hasConceptScore W4313227595C2777074287 @default.
• W4313227595 hasConceptScore W4313227595C2780051329 @default.
• W4313227595 hasConceptScore W4313227595C55493867 @default.
• W4313227595 hasConceptScore W4313227595C71924100 @default.
• W4313227595 hasConceptScore W4313227595C79879829 @default.
• W4313227595 hasConceptScore W4313227595C86803240 @default.
• W4313227595 hasConceptScore W4313227595C98274493 @default.
• W4313227595 hasIssue "4" @default.
• W4313227595 hasLocation W43132275951 @default.
• W4313227595 hasLocation W43132275952 @default.
• W4313227595 hasOpenAccess W4313227595 @default.
• W4313227595 hasPrimaryLocation W43132275951 @default.
• W4313227595 hasRelatedWork W1960500447 @default.
• W4313227595 hasRelatedWork W2031626514 @default.
• W4313227595 hasRelatedWork W2083802751 @default.
• W4313227595 hasRelatedWork W2083954992 @default.
• W4313227595 hasRelatedWork W2116262342 @default.
• W4313227595 hasRelatedWork W2767735742 @default.
• W4313227595 hasRelatedWork W2790108110 @default.
• W4313227595 hasRelatedWork W2888458580 @default.
• W4313227595 hasRelatedWork W3200985662 @default.
• W4313227595 hasRelatedWork W4313909510 @default.
• W4313227595 hasVolume "22" @default.
• W4313227595 isParatext "false" @default.
• W4313227595 isRetracted "false" @default.
• W4313227595 workType "article" @default.