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- W4313231357 abstract "Objective: This study aimed at investigating whether the duration of fermenting Panchgavya (PG) preparation in copper vessel affects its biological activity and microbiome composition.Methods: Prophylactic potential of PG against bacterial infection was assessed through an in vivo assay employing the nematode worm Caenorhabditis elegans as a model host. Bacterial diversity of the PG samples was revealed through metagenomic analysis. Results: Duration of fermentation was found to affect biological activity as well as microbiome composition of the PG samples. PG-samples fermented ≥60 min lost their prophylactic potential, and develop anthelmintic activity. Bacterial phyla whose relative abundance was significantly different between the prophylactic and anthelmintic PG samples were Planctomycetota, Proteabacteria, Bacteroidota, Verrucomicrobiota, Patescibacteria, Acidobacteriota, Chloroflexi, Firmicutes and Campilobacterota.Conclusion: This study validates the prophylactic potential of Panchgavya against bacterial pathogens, and shows that duration of the fermentation time while preparing PG can have profound effect on its biological activities. Biological activities of PG samples seem to have a correlation with their inherent microbial community. Metagenomic profiling can be an effective tool for standardization of PG formulations." @default.
- W4313231357 created "2023-01-06" @default.
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- W4313231357 date "2022-12-28" @default.
- W4313231357 modified "2023-09-23" @default.
- W4313231357 title "Supplementary Videos for: Length of fermentation time affects microbiome composition and biological activity of Panchgavya" @default.
- W4313231357 doi "https://doi.org/10.31219/osf.io/3f8h6" @default.
- W4313231357 hasPublicationYear "2022" @default.
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