Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313231662> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W4313231662 endingPage "159" @default.
- W4313231662 startingPage "154" @default.
- W4313231662 abstract "Abstract The HLA system plays a significant role via the regulation of the immune system and contributes to the progression and protection of many diseases. In our previous study, several HLA‐DRB1 alleles were found to have a susceptible or protective role toward infection and neuroinvasion of West Nile Virus (WNV) in the Greek population. As expected, the majority of polymorphic positions are located in the peptide‐binding region of the molecule. In the present work, the structure of these alleles was studied in silico , to examine the effect of polymorphism on the conformation of DRB1 proteins, with the aspect of WNV association. More specifically, molecular dynamics simulations were used for structural prediction of 23 available alleles. These modeled alleles were evaluated using root‐mean‐square deviation (RMSD) and root‐mean‐square fluctuation analysis. Low RMSD values indicate that different alleles have similar structures. Furthermore, low fluctuation was observed in the peptide‐binding region between alleles with the higher and the lowest RMSD values. These findings indicate that probably variable residues do not affect the behavior of DRB1 alleles in WNV disease, by causing structural differences between them." @default.
- W4313231662 created "2023-01-06" @default.
- W4313231662 creator A5011491311 @default.
- W4313231662 creator A5024157325 @default.
- W4313231662 creator A5070000674 @default.
- W4313231662 date "2023-01-12" @default.
- W4313231662 modified "2023-09-27" @default.
- W4313231662 title "West Nile virus–associated HLA‐DRB1 alleles in the Greek population: A structural perspective" @default.
- W4313231662 cites W1968754404 @default.
- W4313231662 cites W1971837823 @default.
- W4313231662 cites W2020384794 @default.
- W4313231662 cites W2029667189 @default.
- W4313231662 cites W2053396500 @default.
- W4313231662 cites W2059054658 @default.
- W4313231662 cites W2065545999 @default.
- W4313231662 cites W2076154818 @default.
- W4313231662 cites W2079542677 @default.
- W4313231662 cites W2089004428 @default.
- W4313231662 cites W2106882534 @default.
- W4313231662 cites W2112752664 @default.
- W4313231662 cites W2130479394 @default.
- W4313231662 cites W2132262459 @default.
- W4313231662 cites W2134364025 @default.
- W4313231662 cites W2150981663 @default.
- W4313231662 cites W2152997175 @default.
- W4313231662 cites W2156084923 @default.
- W4313231662 cites W2156827437 @default.
- W4313231662 cites W2162166182 @default.
- W4313231662 cites W2170752301 @default.
- W4313231662 cites W2330799739 @default.
- W4313231662 cites W2474452535 @default.
- W4313231662 cites W2547690291 @default.
- W4313231662 cites W3088312576 @default.
- W4313231662 cites W4254539773 @default.
- W4313231662 doi "https://doi.org/10.1111/1348-0421.13048" @default.
- W4313231662 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36578106" @default.
- W4313231662 hasPublicationYear "2023" @default.
- W4313231662 type Work @default.
- W4313231662 citedByCount "0" @default.
- W4313231662 crossrefType "journal-article" @default.
- W4313231662 hasAuthorship W4313231662A5011491311 @default.
- W4313231662 hasAuthorship W4313231662A5024157325 @default.
- W4313231662 hasAuthorship W4313231662A5070000674 @default.
- W4313231662 hasBestOaLocation W43132316621 @default.
- W4313231662 hasConcept C104317684 @default.
- W4313231662 hasConcept C144024400 @default.
- W4313231662 hasConcept C147483822 @default.
- W4313231662 hasConcept C149923435 @default.
- W4313231662 hasConcept C180754005 @default.
- W4313231662 hasConcept C188280979 @default.
- W4313231662 hasConcept C2775905019 @default.
- W4313231662 hasConcept C2908647359 @default.
- W4313231662 hasConcept C54355233 @default.
- W4313231662 hasConcept C86803240 @default.
- W4313231662 hasConceptScore W4313231662C104317684 @default.
- W4313231662 hasConceptScore W4313231662C144024400 @default.
- W4313231662 hasConceptScore W4313231662C147483822 @default.
- W4313231662 hasConceptScore W4313231662C149923435 @default.
- W4313231662 hasConceptScore W4313231662C180754005 @default.
- W4313231662 hasConceptScore W4313231662C188280979 @default.
- W4313231662 hasConceptScore W4313231662C2775905019 @default.
- W4313231662 hasConceptScore W4313231662C2908647359 @default.
- W4313231662 hasConceptScore W4313231662C54355233 @default.
- W4313231662 hasConceptScore W4313231662C86803240 @default.
- W4313231662 hasIssue "3" @default.
- W4313231662 hasLocation W43132316621 @default.
- W4313231662 hasLocation W43132316622 @default.
- W4313231662 hasOpenAccess W4313231662 @default.
- W4313231662 hasPrimaryLocation W43132316621 @default.
- W4313231662 hasRelatedWork W1989613103 @default.
- W4313231662 hasRelatedWork W1990329984 @default.
- W4313231662 hasRelatedWork W1991211153 @default.
- W4313231662 hasRelatedWork W1997924220 @default.
- W4313231662 hasRelatedWork W2006911013 @default.
- W4313231662 hasRelatedWork W2021502563 @default.
- W4313231662 hasRelatedWork W2057739827 @default.
- W4313231662 hasRelatedWork W2067167938 @default.
- W4313231662 hasRelatedWork W2091857464 @default.
- W4313231662 hasRelatedWork W2797561483 @default.
- W4313231662 hasVolume "67" @default.
- W4313231662 isParatext "false" @default.
- W4313231662 isRetracted "false" @default.
- W4313231662 workType "article" @default.