Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313232787> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W4313232787 endingPage "292" @default.
- W4313232787 startingPage "292" @default.
- W4313232787 abstract "Introduction: Liver failure (LF) causes complex coagulation abnormalities leading to bleeding and clotting events. Routinely used plasma-based coagulation (PBC) assays, including international normalized ratio (INR), activated partial thromboplastin time (aPTT), and fibrinogen, have limited bleeding or clotting risk prediction. Whole blood-based viscoelastic assays, including rotational thromboelastometry (ROTEM) and thromboelastography (TEG), are increasingly used to characterize coagulation abnormalities to predict bleeding or clotting events in adults with LF. In this novel study, we aimed to compare PBC assays with ROTEM in pediatric LF as no published data are available yet. Methods: We analyzed a retrospective cohort of children with LF listed for transplant at a tertiary hospital. Samples with simultaneous measurements of PBC assays and ROTEM assays were analyzed. A stratified analysis compared critically ill children admitted to PICU and non-critically ill children from home or acute care before surgery. Results: 63 patients with median age of 38 [IQR 8-149] months, 57% female, 33% in the PICU had 110 simultaneous ROTEM and PBC assays analyzed. About 65% of INR values and 76% of platelet counts were outside the normal range compared to 32% of EXTEM clotting time (CT) (p< 0.001) and 43% of EXTEM maximum clot firmness (MCF) (p< 0.001) respectively. INR showed a weak correlation with EXTEM CT (Spearman’s Coefficient (r)=0.55, p< 0.001) in the entire cohort with no difference between critically ill and not critically ill children. aPTT demonstrated a moderate correlation with INTEM CT (r=0.67, p< 0.001). This correlation was stronger in critically ill children (r=0.78, p< 0.001) compared to the non-critically ill children (r=0.46, p< 0.001). Fibrinogen and platelet count had a strong correlation with FIBTEM and EXTEM MCF (r=0.82 and r=0.80, respectively, p< 0.001) that was similar in the two groups. Conclusions: Children with LF have less frequent coagulation abnormalities on ROTEM compared to PBC assays. INR, traditionally used for prognostication and decision-making, has a weak correlation with EXTEM values on ROTEM regardless of disease severity in children with LF. Determining the association between INR and ROTEM with bleeding or clotting events is needed to ascertain their clinical application." @default.
- W4313232787 created "2023-01-06" @default.
- W4313232787 creator A5000514105 @default.
- W4313232787 creator A5001870974 @default.
- W4313232787 creator A5015053288 @default.
- W4313232787 creator A5022450535 @default.
- W4313232787 creator A5051093718 @default.
- W4313232787 creator A5072849093 @default.
- W4313232787 creator A5074500751 @default.
- W4313232787 date "2022-12-15" @default.
- W4313232787 modified "2023-09-26" @default.
- W4313232787 title "605: CORRELATION BETWEEN PLASMA-BASED AND VISCOELASTIC COAGULATION ASSAYS IN PEDIATRIC LIVER FAILURE" @default.
- W4313232787 doi "https://doi.org/10.1097/01.ccm.0000908152.71171.e9" @default.
- W4313232787 hasPublicationYear "2022" @default.
- W4313232787 type Work @default.
- W4313232787 citedByCount "0" @default.
- W4313232787 crossrefType "journal-article" @default.
- W4313232787 hasAuthorship W4313232787A5000514105 @default.
- W4313232787 hasAuthorship W4313232787A5001870974 @default.
- W4313232787 hasAuthorship W4313232787A5015053288 @default.
- W4313232787 hasAuthorship W4313232787A5022450535 @default.
- W4313232787 hasAuthorship W4313232787A5051093718 @default.
- W4313232787 hasAuthorship W4313232787A5072849093 @default.
- W4313232787 hasAuthorship W4313232787A5074500751 @default.
- W4313232787 hasBestOaLocation W43132327871 @default.
- W4313232787 hasConcept C126322002 @default.
- W4313232787 hasConcept C16124881 @default.
- W4313232787 hasConcept C26809991 @default.
- W4313232787 hasConcept C2777664302 @default.
- W4313232787 hasConcept C2778261982 @default.
- W4313232787 hasConcept C2778382381 @default.
- W4313232787 hasConcept C2779036427 @default.
- W4313232787 hasConcept C2779936836 @default.
- W4313232787 hasConcept C2780434524 @default.
- W4313232787 hasConcept C2908529173 @default.
- W4313232787 hasConcept C42219234 @default.
- W4313232787 hasConcept C71924100 @default.
- W4313232787 hasConcept C77171857 @default.
- W4313232787 hasConcept C90924648 @default.
- W4313232787 hasConceptScore W4313232787C126322002 @default.
- W4313232787 hasConceptScore W4313232787C16124881 @default.
- W4313232787 hasConceptScore W4313232787C26809991 @default.
- W4313232787 hasConceptScore W4313232787C2777664302 @default.
- W4313232787 hasConceptScore W4313232787C2778261982 @default.
- W4313232787 hasConceptScore W4313232787C2778382381 @default.
- W4313232787 hasConceptScore W4313232787C2779036427 @default.
- W4313232787 hasConceptScore W4313232787C2779936836 @default.
- W4313232787 hasConceptScore W4313232787C2780434524 @default.
- W4313232787 hasConceptScore W4313232787C2908529173 @default.
- W4313232787 hasConceptScore W4313232787C42219234 @default.
- W4313232787 hasConceptScore W4313232787C71924100 @default.
- W4313232787 hasConceptScore W4313232787C77171857 @default.
- W4313232787 hasConceptScore W4313232787C90924648 @default.
- W4313232787 hasIssue "1" @default.
- W4313232787 hasLocation W43132327871 @default.
- W4313232787 hasLocation W43132327872 @default.
- W4313232787 hasOpenAccess W4313232787 @default.
- W4313232787 hasPrimaryLocation W43132327871 @default.
- W4313232787 hasRelatedWork W1998793931 @default.
- W4313232787 hasRelatedWork W2013683320 @default.
- W4313232787 hasRelatedWork W2027521363 @default.
- W4313232787 hasRelatedWork W2323379141 @default.
- W4313232787 hasRelatedWork W2379432586 @default.
- W4313232787 hasRelatedWork W2475897384 @default.
- W4313232787 hasRelatedWork W2660767330 @default.
- W4313232787 hasRelatedWork W2801463464 @default.
- W4313232787 hasRelatedWork W2980278476 @default.
- W4313232787 hasRelatedWork W4313232787 @default.
- W4313232787 hasVolume "51" @default.
- W4313232787 isParatext "false" @default.
- W4313232787 isRetracted "false" @default.
- W4313232787 workType "article" @default.