FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313235953> ?p ?o ?g. }

• W4313235953 endingPage "244" @default.
• W4313235953 startingPage "244" @default.
• W4313235953 abstract "Introduction: Traumatic brain injury (TBI) can result in complications of prolonged disorders of consciousness (DOC) including a coma, vegetative, or minimally conscious state. Patients with DOC are assessed utilizing the Glasgow Coma Scale (GCS) and Activity Measure for Post-Acute Care (AM-PAC) score. Amantadine may provide an accelerated rate of return to consciousness for TBI patients, but literature assessing its use in relation to cognitive recovery during acute hospitalization is lacking. This study aimed to evaluate the effect of amantadine in improving wakefulness for TBI patients during the acute phase of hospitalization. Methods: This was a retrospective, single-center, single-group cohort review of patients admitted to Carilion Roanoke Memorial Hospital receiving amantadine for TBI. Patients were excluded if they received amantadine for less than 3 consecutive days, prior to admission, or for alternative indications. The primary outcome was the median change in cognition 7 days after therapy initiation and at discharge. Descriptive statistics and an analysis of variance (ANOVA) were utilized for data analysis. Results: Of 96 subjects identified, 75 were included for analysis. The median change in cognition after initiation of amantadine as determined by the GCS was 2 (n=65) at day 7 and 6 (n=75) at discharge, in which the median hospital length of stay was 22 days. The median changes in AMPAC scores were 3 and 5, respectively. The median duration of amantadine therapy was 11 days with a usual daily dose of 100 to 200 mg. The most common adverse effect observed was tachycardia, followed by insomnia. A two-way ANOVA revealed that there was not a statistically significant interaction between TBI severity and the presence of alternative psychotropic medications at day 7 or discharge (p=0.84, p=0.22). TBI severity alone had a significant effect on GCS at discharge, but not at day 7 (p< 0.0001, p=0.12). Conclusions: Amantadine may play an important role in TBI patients, as GCS and AM-PAC scores increased after starting therapy. The severity of TBI likely contributed to the changes observed in GCS scores. Given the small sample size and lack of comparator group, it is difficult to determine the clinical significance of amantadine use. More data is needed to support the use of amantadine in acute TBI." @default.
• W4313235953 created "2023-01-06" @default.
• W4313235953 creator A5028172559 @default.
• W4313235953 creator A5053491215 @default.
• W4313235953 creator A5055980401 @default.
• W4313235953 creator A5068580526 @default.
• W4313235953 creator A5083732282 @default.
• W4313235953 creator A5089806165 @default.
• W4313235953 date "2022-12-15" @default.
• W4313235953 modified "2023-10-17" @default.
• W4313235953 title "514: EVALUATION OF AMANTADINE ON COGNITIVE OUTCOMES IN TRAUMATIC BRAIN INJURY PATIENTS" @default.
• W4313235953 doi "https://doi.org/10.1097/01.ccm.0000907784.42226.2a" @default.
• W4313235953 hasPublicationYear "2022" @default.
• W4313235953 type Work @default.
• W4313235953 citedByCount "0" @default.
• W4313235953 crossrefType "journal-article" @default.
• W4313235953 hasAuthorship W4313235953A5028172559 @default.
• W4313235953 hasAuthorship W4313235953A5053491215 @default.
• W4313235953 hasAuthorship W4313235953A5055980401 @default.
• W4313235953 hasAuthorship W4313235953A5068580526 @default.
• W4313235953 hasAuthorship W4313235953A5083732282 @default.
• W4313235953 hasAuthorship W4313235953A5089806165 @default.
• W4313235953 hasBestOaLocation W43132359531 @default.
• W4313235953 hasConcept C100136789 @default.
• W4313235953 hasConcept C118552586 @default.
• W4313235953 hasConcept C120665830 @default.
• W4313235953 hasConcept C121332964 @default.
• W4313235953 hasConcept C15744967 @default.
• W4313235953 hasConcept C169760540 @default.
• W4313235953 hasConcept C17624336 @default.
• W4313235953 hasConcept C186720457 @default.
• W4313235953 hasConcept C187212893 @default.
• W4313235953 hasConcept C2777374534 @default.
• W4313235953 hasConcept C2778170955 @default.
• W4313235953 hasConcept C2781017439 @default.
• W4313235953 hasConcept C42219234 @default.
• W4313235953 hasConcept C71924100 @default.
• W4313235953 hasConcept C98274493 @default.
• W4313235953 hasConceptScore W4313235953C100136789 @default.
• W4313235953 hasConceptScore W4313235953C118552586 @default.
• W4313235953 hasConceptScore W4313235953C120665830 @default.
• W4313235953 hasConceptScore W4313235953C121332964 @default.
• W4313235953 hasConceptScore W4313235953C15744967 @default.
• W4313235953 hasConceptScore W4313235953C169760540 @default.
• W4313235953 hasConceptScore W4313235953C17624336 @default.
• W4313235953 hasConceptScore W4313235953C186720457 @default.
• W4313235953 hasConceptScore W4313235953C187212893 @default.
• W4313235953 hasConceptScore W4313235953C2777374534 @default.
• W4313235953 hasConceptScore W4313235953C2778170955 @default.
• W4313235953 hasConceptScore W4313235953C2781017439 @default.
• W4313235953 hasConceptScore W4313235953C42219234 @default.
• W4313235953 hasConceptScore W4313235953C71924100 @default.
• W4313235953 hasConceptScore W4313235953C98274493 @default.
• W4313235953 hasIssue "1" @default.
• W4313235953 hasLocation W43132359531 @default.
• W4313235953 hasLocation W43132359532 @default.
• W4313235953 hasOpenAccess W4313235953 @default.
• W4313235953 hasPrimaryLocation W43132359531 @default.
• W4313235953 hasRelatedWork W1607672146 @default.
• W4313235953 hasRelatedWork W2074655573 @default.
• W4313235953 hasRelatedWork W2093765285 @default.
• W4313235953 hasRelatedWork W2147295899 @default.
• W4313235953 hasRelatedWork W2153242524 @default.
• W4313235953 hasRelatedWork W2921721869 @default.
• W4313235953 hasRelatedWork W2931918087 @default.
• W4313235953 hasRelatedWork W3011547141 @default.
• W4313235953 hasRelatedWork W4213323363 @default.
• W4313235953 hasRelatedWork W4292133522 @default.
• W4313235953 hasVolume "51" @default.
• W4313235953 isParatext "false" @default.
• W4313235953 isRetracted "false" @default.
• W4313235953 workType "article" @default.