FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313235956> ?p ?o ?g. }

• W4313235956 endingPage "25" @default.
• W4313235956 startingPage "25" @default.
• W4313235956 abstract "Visceral leishmaniasis (VL), also known as kala-azar, is an anthropozoonotic disease affecting human populations on five continents. Aetiologic agents belong to the Leishmania (L.) donovani complex. Until the 1990s, three leishmanine parasites comprised this complex: L. (L.) donovani Laveran & Mesnil 1903, L. (L.) infantum Nicolle 1908, and L. (L.) chagasi Lainson & Shaw 1987 (=L. chagasi Cunha & Chagas 1937). The VL causal agent in the New World (NW) was previously identified as L. (L.) chagasi. After the development of molecular characterization, however, comparisons between L. (L.) chagasi and L. (L.) infantum showed high similarity, and L. (L.) chagasi was then regarded as synonymous with L. (L.) infantum. It was, therefore, suggested that L. (L.) chagasi was not native to the NW but had been introduced from the Old World by Iberian colonizers. However, in light of ecological evidence from the NW parasite’s enzootic cycle involving a wild phlebotomine vector (Lutzomyia longipalpis) and a wild mammal reservoir (the fox, Cerdocyon thous), we have recently analyzed by molecular clock comparisons of the DNA polymerase alpha subunit gene the whole-genome sequence of L. (L.) infantum chagasi of the most prevalent clinical form, atypical dermal leishmaniasis (ADL), from Honduras (Central America) with that of the same parasite from Brazil (South America), as well as those of L. (L.) donovani (India) and L. (L.) infantum (Europe), which revealed that the Honduran parasite is older ancestry (382,800 ya) than the parasite from Brazil (143,300 ya), L. (L.) donovani (33,776 ya), or L. (L.) infantum (13,000 ya). In the present work, we have now amplified the genomic comparisons among these leishmanine parasites, exploring mainly the variations in the genome for each chromosome, and the number of genomic SNPs for each chromosome. Although the results of this new analysis have confirmed a high genomic similarity (~99%) among these parasites [except L. (L.) donovani], the Honduran parasite revealed a single structural variation on chromosome 17, and the highest frequency of genomic SNPs (more than twice the number seen in the Brazilian one), which together to its extraordinary ancestry (382,800 ya) represent strong evidence that L. (L.) chagasi/L. (L.) infantum chagasi is, in fact, native to the NW, and therefore with valid taxonomic status. Furthermore, the Honduran parasite, the most ancestral viscerotropic leishmanine parasite, showed genomic and clinical taxonomic characteristics compatible with a new Leishmania species causing ADL in Central America." @default.
• W4313235956 created "2023-01-06" @default.
• W4313235956 creator A5002011943 @default.
• W4313235956 creator A5005618804 @default.
• W4313235956 creator A5007847907 @default.
• W4313235956 creator A5027479238 @default.
• W4313235956 creator A5028158569 @default.
• W4313235956 creator A5037796346 @default.
• W4313235956 creator A5043437431 @default.
• W4313235956 creator A5054537404 @default.
• W4313235956 creator A5063153842 @default.
• W4313235956 creator A5066102971 @default.
• W4313235956 creator A5066684499 @default.
• W4313235956 creator A5067387355 @default.
• W4313235956 creator A5067711524 @default.
• W4313235956 creator A5067943057 @default.
• W4313235956 creator A5074447256 @default.
• W4313235956 creator A5080686558 @default.
• W4313235956 date "2022-12-21" @default.
• W4313235956 modified "2023-10-11" @default.
• W4313235956 title "Comparative Genomic Analyses of New and Old World Viscerotropic Leishmanine Parasites: Further Insights into the Origins of Visceral Leishmaniasis Agents" @default.
• W4313235956 cites W1945342477 @default.
• W4313235956 cites W1973023457 @default.
• W4313235956 cites W1984158365 @default.
• W4313235956 cites W1989265466 @default.
• W4313235956 cites W1991176783 @default.
• W4313235956 cites W1991803324 @default.
• W4313235956 cites W2001241804 @default.
• W4313235956 cites W2009610464 @default.
• W4313235956 cites W2022802872 @default.
• W4313235956 cites W2039479221 @default.
• W4313235956 cites W2039502062 @default.
• W4313235956 cites W2043422528 @default.
• W4313235956 cites W2046306052 @default.
• W4313235956 cites W2051286370 @default.
• W4313235956 cites W2052664899 @default.
• W4313235956 cites W2061017686 @default.
• W4313235956 cites W2062590826 @default.
• W4313235956 cites W2064281458 @default.
• W4313235956 cites W2064516185 @default.
• W4313235956 cites W2071457606 @default.
• W4313235956 cites W2078120258 @default.
• W4313235956 cites W2090681071 @default.
• W4313235956 cites W2096643572 @default.
• W4313235956 cites W2098031413 @default.
• W4313235956 cites W2099595384 @default.
• W4313235956 cites W2102667591 @default.
• W4313235956 cites W2105005554 @default.
• W4313235956 cites W2107915297 @default.
• W4313235956 cites W2107999316 @default.
• W4313235956 cites W2109521607 @default.
• W4313235956 cites W2109936637 @default.
• W4313235956 cites W2120902911 @default.
• W4313235956 cites W2128880918 @default.
• W4313235956 cites W2129223498 @default.
• W4313235956 cites W2131271579 @default.
• W4313235956 cites W2159788157 @default.
• W4313235956 cites W2163432338 @default.
• W4313235956 cites W2170302951 @default.
• W4313235956 cites W2170834744 @default.
• W4313235956 cites W2172103887 @default.
• W4313235956 cites W2260543582 @default.
• W4313235956 cites W2296520086 @default.
• W4313235956 cites W2304889307 @default.
• W4313235956 cites W2338978258 @default.
• W4313235956 cites W2396242124 @default.
• W4313235956 cites W2410825640 @default.
• W4313235956 cites W2471527052 @default.
• W4313235956 cites W2563282424 @default.
• W4313235956 cites W2569520352 @default.
• W4313235956 cites W2575471090 @default.
• W4313235956 cites W2596995519 @default.
• W4313235956 cites W2612178877 @default.
• W4313235956 cites W2623307980 @default.
• W4313235956 cites W2749460447 @default.
• W4313235956 cites W2944551448 @default.
• W4313235956 cites W2951959521 @default.
• W4313235956 cites W2972223174 @default.
• W4313235956 cites W2979939465 @default.
• W4313235956 cites W2995419889 @default.
• W4313235956 cites W2996465260 @default.
• W4313235956 cites W3014059824 @default.
• W4313235956 cites W3042103932 @default.
• W4313235956 cites W3139651602 @default.
• W4313235956 cites W3150635270 @default.
• W4313235956 cites W4226197945 @default.
• W4313235956 doi "https://doi.org/10.3390/microorganisms11010025" @default.
• W4313235956 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36677318" @default.
• W4313235956 hasPublicationYear "2022" @default.
• W4313235956 type Work @default.
• W4313235956 citedByCount "5" @default.
• W4313235956 countsByYear W43132359562023 @default.
• W4313235956 crossrefType "journal-article" @default.
• W4313235956 hasAuthorship W4313235956A5002011943 @default.
• W4313235956 hasAuthorship W4313235956A5005618804 @default.
• W4313235956 hasAuthorship W4313235956A5007847907 @default.
• W4313235956 hasAuthorship W4313235956A5027479238 @default.
• W4313235956 hasAuthorship W4313235956A5028158569 @default.

• next