FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313236327> ?p ?o ?g. }

• W4313236327 endingPage "160" @default.
• W4313236327 startingPage "160" @default.
• W4313236327 abstract "Importance Primary cutaneous squamous cell carcinoma is usually curable; however, a subset of patients develops poor outcomes, including local recurrence, nodal metastasis, distant metastasis, and disease-specific death. Objectives To evaluate all evidence-based reports of patient risk factors and tumor characteristics associated with poor outcomes in primary cutaneous squamous cell carcinoma and to identify treatment modalities that minimize poor outcomes. Data Sources PubMed, Embase, and SCOPUS databases were searched for studies of the topic in humans, published in the English language, from database inception through February 8, 2022. Study Selection Two authors independently screened the identified articles and included those that were original research with a sample size of 10 patients or more and that assessed risk factors and/or treatment modalities associated with poor outcomes among patients with primary cutaneous squamous cell carcinoma. Data Extraction and Synthesis Data extraction was performed by a single author, per international guidelines. The search terms, study objectives, and protocol methods were defined before study initiation. A total of 310 studies were included for full-text assessment. Owing to heterogeneity of the included studies, a random-effects model was used. Data analyses were performed from May 25 to September 15, 2022. Main Outcomes and Measures For studies of risk factors, risk ratios and incidence proportions; and for treatment studies, incidence proportions. Results In all, 129 studies and a total of 137 449 patients with primary cutaneous squamous cell carcinoma and 126 553 tumors were included in the meta-analysis. Several patient risk factors and tumor characteristics were associated with local recurrence, nodal metastasis, distant metastasis, disease-specific death, and all-cause death were identified. Among all factors reported by more than 1 study, the highest risks for local recurrence and disease-specific death were associated with tumor invasion beyond subcutaneous fat (risk ratio, 9.1 [95% CI, 2.8-29.2] and 10.4 [95% CI, 3.0- 36.3], respectively), and the highest risk of any metastasis was associated with perineural invasion (risk ratio, 5.0; 95% CI, 2.3-11.1). Patients who received Mohs micrographic surgery had the lowest incidence of nearly all poor outcomes; however, in some results, the 95% CIs overlapped with those of other treatment modalities. Conclusions and Relevance This meta-analysis identified the prognostic value of several risk factors and the effectiveness of the available treatment modalities. These findings carry important implications for the prognostication, workup, treatment, and follow-up of patients with primary cutaneous squamous cell carcinoma. Trial Registration PROSPERO Identifier: CRD42022311250" @default.
• W4313236327 created "2023-01-06" @default.
• W4313236327 creator A5009333007 @default.
• W4313236327 creator A5043019350 @default.
• W4313236327 creator A5051949472 @default.
• W4313236327 creator A5080001496 @default.
• W4313236327 date "2023-02-01" @default.
• W4313236327 modified "2023-10-15" @default.
• W4313236327 title "Association of Patient Risk Factors, Tumor Characteristics, and Treatment Modality With Poor Outcomes in Primary Cutaneous Squamous Cell Carcinoma" @default.
• W4313236327 cites W1516602561 @default.
• W4313236327 cites W1540040766 @default.
• W4313236327 cites W1563440141 @default.
• W4313236327 cites W1569407794 @default.
• W4313236327 cites W1594237846 @default.
• W4313236327 cites W1791637602 @default.
• W4313236327 cites W1905895728 @default.
• W4313236327 cites W1971199765 @default.
• W4313236327 cites W1977968587 @default.
• W4313236327 cites W1981501248 @default.
• W4313236327 cites W1983103562 @default.
• W4313236327 cites W1992077682 @default.
• W4313236327 cites W1994136786 @default.
• W4313236327 cites W2000834428 @default.
• W4313236327 cites W2003589889 @default.
• W4313236327 cites W2005278889 @default.
• W4313236327 cites W2034670381 @default.
• W4313236327 cites W2038702881 @default.
• W4313236327 cites W2040600853 @default.
• W4313236327 cites W2041972418 @default.
• W4313236327 cites W2047369892 @default.
• W4313236327 cites W2054342443 @default.
• W4313236327 cites W2057388449 @default.
• W4313236327 cites W2074549420 @default.
• W4313236327 cites W2077325660 @default.
• W4313236327 cites W2077803316 @default.
• W4313236327 cites W2078159813 @default.
• W4313236327 cites W2085725730 @default.
• W4313236327 cites W2086238536 @default.
• W4313236327 cites W2089167013 @default.
• W4313236327 cites W2089815625 @default.
• W4313236327 cites W2098923148 @default.
• W4313236327 cites W2101226266 @default.
• W4313236327 cites W2103328907 @default.
• W4313236327 cites W2121557104 @default.
• W4313236327 cites W2146086092 @default.
• W4313236327 cites W2155934287 @default.
• W4313236327 cites W2170144295 @default.
• W4313236327 cites W2171362247 @default.
• W4313236327 cites W2171921092 @default.
• W4313236327 cites W2289606030 @default.
• W4313236327 cites W2298536098 @default.
• W4313236327 cites W2322753818 @default.
• W4313236327 cites W2339226289 @default.
• W4313236327 cites W2344197996 @default.
• W4313236327 cites W2494141721 @default.
• W4313236327 cites W2502134830 @default.
• W4313236327 cites W2506645025 @default.
• W4313236327 cites W2512509856 @default.
• W4313236327 cites W2552537175 @default.
• W4313236327 cites W2559539643 @default.
• W4313236327 cites W2579371903 @default.
• W4313236327 cites W2583882410 @default.
• W4313236327 cites W2588314035 @default.
• W4313236327 cites W2598930814 @default.
• W4313236327 cites W2598943329 @default.
• W4313236327 cites W2600084262 @default.
• W4313236327 cites W2618115627 @default.
• W4313236327 cites W2735457040 @default.
• W4313236327 cites W2736279675 @default.
• W4313236327 cites W2739253962 @default.
• W4313236327 cites W2770261298 @default.
• W4313236327 cites W2789601368 @default.
• W4313236327 cites W2865270765 @default.
• W4313236327 cites W2890954265 @default.
• W4313236327 cites W2903383393 @default.
• W4313236327 cites W2905612293 @default.
• W4313236327 cites W2910044211 @default.
• W4313236327 cites W2918233855 @default.
• W4313236327 cites W2931202609 @default.
• W4313236327 cites W2938329980 @default.
• W4313236327 cites W2945794251 @default.
• W4313236327 cites W2955206196 @default.
• W4313236327 cites W2963114043 @default.
• W4313236327 cites W2967216700 @default.
• W4313236327 cites W2973069859 @default.
• W4313236327 cites W2979156840 @default.
• W4313236327 cites W2990215198 @default.
• W4313236327 cites W2992169740 @default.
• W4313236327 cites W2996712639 @default.
• W4313236327 cites W2997998624 @default.
• W4313236327 cites W3011292439 @default.
• W4313236327 cites W3011451522 @default.
• W4313236327 cites W3014813912 @default.
• W4313236327 cites W3015336235 @default.
• W4313236327 cites W3021877543 @default.
• W4313236327 cites W3026000165 @default.
• W4313236327 cites W3040161126 @default.
• W4313236327 cites W3047738322 @default.

• next