Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313236431> ?p ?o ?g. }
- W4313236431 endingPage "1001" @default.
- W4313236431 startingPage "988" @default.
- W4313236431 abstract "Abstract AzoChignolin is a photoswitchable variant of the mini‐protein Chignolin with an azobenzene (AMPP) replacing the central loop. AzoChignolin is unfolded with AMPP in the trans‐isomer. Transition to the cis‐isomer causes β ‐hairpin folding similar to Chignolin. The AzoChignolin system is excellently suited for comprehensive analysis of folding nucleation kinetics. Utilizing multiple long‐time MD simulations of AzoChignolin and Chignolin in MeOH and water, we estimated Markov models to examine folding kinetics of both peptides. We show that while AzoChignolin mimics Chignolin's structure well, the folding kinetics are quite different. Not only folding times but also intermediate states differ, particularly Chignolin is able to fold in MeOH into an α ‐helical intermediate which is impossible to form in AzoChignolin. The Markov models demonstrate that AzoChignolin's kinetics are generally faster, specifically when comparing the two main microfolding processes of hydrophobic collapse and turn formation. Photoswitchable loops are used frequently to understand the kinetics of elementary protein folding nucleation. However, our results indicate that intermediates and folding kinetics may differ between natural loops and photoswitchable variants." @default.
- W4313236431 created "2023-01-06" @default.
- W4313236431 creator A5056186108 @default.
- W4313236431 creator A5090330416 @default.
- W4313236431 date "2022-12-28" @default.
- W4313236431 modified "2023-10-17" @default.
- W4313236431 title "Mechanism of <i>β</i>‐hairpin formation in <scp>AzoChignolin</scp> and Chignolin" @default.
- W4313236431 cites W1965156062 @default.
- W4313236431 cites W1967734507 @default.
- W4313236431 cites W1968707111 @default.
- W4313236431 cites W1968984443 @default.
- W4313236431 cites W1969189143 @default.
- W4313236431 cites W1976499671 @default.
- W4313236431 cites W1992045220 @default.
- W4313236431 cites W1992924464 @default.
- W4313236431 cites W2007170180 @default.
- W4313236431 cites W2008708467 @default.
- W4313236431 cites W2015688756 @default.
- W4313236431 cites W2016336300 @default.
- W4313236431 cites W2035266068 @default.
- W4313236431 cites W2035687084 @default.
- W4313236431 cites W2050961477 @default.
- W4313236431 cites W2053160116 @default.
- W4313236431 cites W2059797074 @default.
- W4313236431 cites W2063021109 @default.
- W4313236431 cites W2067236515 @default.
- W4313236431 cites W2076416105 @default.
- W4313236431 cites W2085213650 @default.
- W4313236431 cites W2085908066 @default.
- W4313236431 cites W2103945336 @default.
- W4313236431 cites W2115113978 @default.
- W4313236431 cites W2134661315 @default.
- W4313236431 cites W2137195231 @default.
- W4313236431 cites W2140340353 @default.
- W4313236431 cites W2147988069 @default.
- W4313236431 cites W2147993766 @default.
- W4313236431 cites W2165835468 @default.
- W4313236431 cites W2226825552 @default.
- W4313236431 cites W2315297180 @default.
- W4313236431 cites W2329540625 @default.
- W4313236431 cites W2330621114 @default.
- W4313236431 cites W2332712348 @default.
- W4313236431 cites W2404280981 @default.
- W4313236431 cites W2623055862 @default.
- W4313236431 cites W2906950859 @default.
- W4313236431 cites W2910535194 @default.
- W4313236431 cites W2951082339 @default.
- W4313236431 cites W2964149432 @default.
- W4313236431 cites W3030546763 @default.
- W4313236431 cites W3100312042 @default.
- W4313236431 cites W3100810942 @default.
- W4313236431 cites W3106119883 @default.
- W4313236431 cites W3209850868 @default.
- W4313236431 doi "https://doi.org/10.1002/jcc.27059" @default.
- W4313236431 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36575994" @default.
- W4313236431 hasPublicationYear "2022" @default.
- W4313236431 type Work @default.
- W4313236431 citedByCount "0" @default.
- W4313236431 crossrefType "journal-article" @default.
- W4313236431 hasAuthorship W4313236431A5056186108 @default.
- W4313236431 hasAuthorship W4313236431A5090330416 @default.
- W4313236431 hasBestOaLocation W43132364311 @default.
- W4313236431 hasConcept C119599485 @default.
- W4313236431 hasConcept C121332964 @default.
- W4313236431 hasConcept C12554922 @default.
- W4313236431 hasConcept C127413603 @default.
- W4313236431 hasConcept C147597530 @default.
- W4313236431 hasConcept C148898269 @default.
- W4313236431 hasConcept C162203774 @default.
- W4313236431 hasConcept C178790620 @default.
- W4313236431 hasConcept C185592680 @default.
- W4313236431 hasConcept C204328495 @default.
- W4313236431 hasConcept C2776545253 @default.
- W4313236431 hasConcept C2778150588 @default.
- W4313236431 hasConcept C32909587 @default.
- W4313236431 hasConcept C46449900 @default.
- W4313236431 hasConcept C55493867 @default.
- W4313236431 hasConcept C59593255 @default.
- W4313236431 hasConcept C61048295 @default.
- W4313236431 hasConcept C62520636 @default.
- W4313236431 hasConcept C8010536 @default.
- W4313236431 hasConcept C86803240 @default.
- W4313236431 hasConceptScore W4313236431C119599485 @default.
- W4313236431 hasConceptScore W4313236431C121332964 @default.
- W4313236431 hasConceptScore W4313236431C12554922 @default.
- W4313236431 hasConceptScore W4313236431C127413603 @default.
- W4313236431 hasConceptScore W4313236431C147597530 @default.
- W4313236431 hasConceptScore W4313236431C148898269 @default.
- W4313236431 hasConceptScore W4313236431C162203774 @default.
- W4313236431 hasConceptScore W4313236431C178790620 @default.
- W4313236431 hasConceptScore W4313236431C185592680 @default.
- W4313236431 hasConceptScore W4313236431C204328495 @default.
- W4313236431 hasConceptScore W4313236431C2776545253 @default.
- W4313236431 hasConceptScore W4313236431C2778150588 @default.
- W4313236431 hasConceptScore W4313236431C32909587 @default.
- W4313236431 hasConceptScore W4313236431C46449900 @default.
- W4313236431 hasConceptScore W4313236431C55493867 @default.
- W4313236431 hasConceptScore W4313236431C59593255 @default.