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• W4313236441 endingPage "1886" @default.
• W4313236441 startingPage "1886" @default.
• W4313236441 abstract "Insulin degrading enzyme (IDE) has been detected in the cerebrospinal fluid media and plays a role in encapsulating and degrading the amyloid β (Aβ) monomer, thus regulating the levels of Aβ monomers. The current work illustrates a first study by which IDE encapsulates polymorphic early-stage Aβ oligomers. The main goal of this study was to investigate the molecular mechanisms of IDE activity on the encapsulated early-stage Aβ dimers: fibril-like and random coil/α-helix dimers. Our work led to several findings. First, when the fibril-like Aβ dimer interacts with IDE-C domain, IDE does not impede the contact between the monomers, but plays a role as a 'dead-end' chaperone protein. Second, when the fibril-like Aβ dimer interacts with the IDE-N domain, IDE successfully impedes the contacts between monomers. Third, the inhibitory activity of IDE on random coil/α-helix dimers depends on the stability of the dimer. IDE could impede the contacts between monomers in relatively unstable random coil/α-helix dimers, but gets hard to impede in stable dimers. However, IDE encapsulates stable dimers and could serve as a 'dead-end' chaperone. Our results examine the molecular interactions between IDE and the dimers, and between the monomers within the dimers. Hence, this study provides insights into the inhibition mechanisms of the primary nucleation of Aβ aggregation and the basic knowledge for rational design to inhibit Aβ aggregation." @default.
• W4313236441 created "2023-01-06" @default.
• W4313236441 creator A5027274925 @default.
• W4313236441 creator A5073235081 @default.
• W4313236441 date "2022-12-16" @default.
• W4313236441 modified "2023-10-13" @default.
• W4313236441 title "Insights into Non-Proteolytic Inhibitory Mechanisms of Polymorphic Early-Stage Amyloid β Oligomers by Insulin Degrading Enzyme" @default.
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• W4313236441 doi "https://doi.org/10.3390/biom12121886" @default.
• W4313236441 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36551314" @default.
• W4313236441 hasPublicationYear "2022" @default.
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