FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313236507> ?p ?o ?g. }

• W4313236507 endingPage "16" @default.
• W4313236507 startingPage "1" @default.
• W4313236507 abstract "The SARS-CoV-2 'Omicron' strain, with 15 mutations in the receptor binding domain (RBD), was detected in South Africa and rapidly spread worldwide. SARS-CoV-2 ORF9b protein by binding to the TOM70 receptor and ORF8 protein by binding to MHC-I, IF3 receptors inhibit the host's immune response. In this study, genomics variations were evaluated for 96 samples isolated from Iran from March to July 2022 using the Nextclade web server and informatics tools. We identified the mutations occurring in the SARS-CoV-2 proteins. We also evaluated the effect of mutations on spike protein interaction with the ACE2 receptor, ORF9b protein interaction with the TOM70 receptor, and structural stability of ORF8 and nucleocapsid proteins using docking and molecular dynamics. Results indicated that during March and April 2022, the BA.2 strain was dominant in the south of Iran, while during June 2022, the BA.5 strain was dominant. BF.5 strain had the most divergence among SARS-CoV-2 strains reported from south of Iran. The binding affinity of BA.5 and BF.5 strains spike protein to ACE2 receptor is similar, and compared to BA.2 strain, was stronger. The BF.5 ORF9b K40R mutation causes a better binding affinity of the protein to the TOM70 receptor. Also, mutations that occurred in the ORF8 protein led to instability in the dimer formation of this protein and improved immune response for mutations that occurred in BA.2 strain, while this mutation did not occur in BF.5 strain. The mutations that were detected in nucleocapsid protein CTD and NTD domains caused the stability of these domains.Communicated by Ramaswamy H. Sarma." @default.
• W4313236507 created "2023-01-06" @default.
• W4313236507 creator A5032762638 @default.
• W4313236507 creator A5045745941 @default.
• W4313236507 creator A5048243560 @default.
• W4313236507 creator A5062111919 @default.
• W4313236507 date "2022-12-28" @default.
• W4313236507 modified "2023-10-03" @default.
• W4313236507 title "Characterization of <i>SARS-CoV-2</i> omicron variants from Iran and evaluation of the effect of mutations on the spike, nucleocapsid, ORF8, and ORF9b proteins function" @default.
• W4313236507 cites W1031578623 @default.
• W4313236507 cites W1991003805 @default.
• W4313236507 cites W2011658408 @default.
• W4313236507 cites W2026516400 @default.
• W4313236507 cites W2081912151 @default.
• W4313236507 cites W2154915448 @default.
• W4313236507 cites W2605343262 @default.
• W4313236507 cites W3001456238 @default.
• W4313236507 cites W3007643904 @default.
• W4313236507 cites W3018221920 @default.
• W4313236507 cites W3045756756 @default.
• W4313236507 cites W3060075221 @default.
• W4313236507 cites W3109368861 @default.
• W4313236507 cites W3111123462 @default.
• W4313236507 cites W3114096059 @default.
• W4313236507 cites W3117073871 @default.
• W4313236507 cites W3117730334 @default.
• W4313236507 cites W3119453605 @default.
• W4313236507 cites W3130138583 @default.
• W4313236507 cites W3135748407 @default.
• W4313236507 cites W3157458452 @default.
• W4313236507 cites W3158953228 @default.
• W4313236507 cites W3161424923 @default.
• W4313236507 cites W3161468411 @default.
• W4313236507 cites W3165479483 @default.
• W4313236507 cites W3173623385 @default.
• W4313236507 cites W3209548944 @default.
• W4313236507 cites W4200340032 @default.
• W4313236507 cites W4200429845 @default.
• W4313236507 cites W4205849319 @default.
• W4313236507 cites W4206787465 @default.
• W4313236507 cites W4206979529 @default.
• W4313236507 cites W4210390491 @default.
• W4313236507 cites W4212857232 @default.
• W4313236507 cites W4225291738 @default.
• W4313236507 cites W4229332156 @default.
• W4313236507 cites W4280547566 @default.
• W4313236507 cites W4281559806 @default.
• W4313236507 cites W4281939105 @default.
• W4313236507 cites W4283576315 @default.
• W4313236507 cites W4283654132 @default.
• W4313236507 cites W4283693800 @default.
• W4313236507 cites W4285993171 @default.
• W4313236507 cites W4306405700 @default.
• W4313236507 doi "https://doi.org/10.1080/07391102.2022.2162131" @default.
• W4313236507 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36576175" @default.
• W4313236507 hasPublicationYear "2022" @default.
• W4313236507 type Work @default.
• W4313236507 citedByCount "1" @default.
• W4313236507 countsByYear W43132365072023 @default.
• W4313236507 crossrefType "journal-article" @default.
• W4313236507 hasAuthorship W4313236507A5032762638 @default.
• W4313236507 hasAuthorship W4313236507A5045745941 @default.
• W4313236507 hasAuthorship W4313236507A5048243560 @default.
• W4313236507 hasAuthorship W4313236507A5062111919 @default.
• W4313236507 hasConcept C104317684 @default.
• W4313236507 hasConcept C105702510 @default.
• W4313236507 hasConcept C153911025 @default.
• W4313236507 hasConcept C170493617 @default.
• W4313236507 hasConcept C2778022156 @default.
• W4313236507 hasConcept C501734568 @default.
• W4313236507 hasConcept C54355233 @default.
• W4313236507 hasConcept C86803240 @default.
• W4313236507 hasConceptScore W4313236507C104317684 @default.
• W4313236507 hasConceptScore W4313236507C105702510 @default.
• W4313236507 hasConceptScore W4313236507C153911025 @default.
• W4313236507 hasConceptScore W4313236507C170493617 @default.
• W4313236507 hasConceptScore W4313236507C2778022156 @default.
• W4313236507 hasConceptScore W4313236507C501734568 @default.
• W4313236507 hasConceptScore W4313236507C54355233 @default.
• W4313236507 hasConceptScore W4313236507C86803240 @default.
• W4313236507 hasFunder F4320327362 @default.
• W4313236507 hasLocation W43132365071 @default.
• W4313236507 hasLocation W43132365072 @default.
• W4313236507 hasOpenAccess W4313236507 @default.
• W4313236507 hasPrimaryLocation W43132365071 @default.
• W4313236507 hasRelatedWork W1968369877 @default.
• W4313236507 hasRelatedWork W1972900772 @default.
• W4313236507 hasRelatedWork W2354435317 @default.
• W4313236507 hasRelatedWork W2361459801 @default.
• W4313236507 hasRelatedWork W2364620227 @default.
• W4313236507 hasRelatedWork W2371650228 @default.
• W4313236507 hasRelatedWork W2376109144 @default.
• W4313236507 hasRelatedWork W2381348793 @default.
• W4313236507 hasRelatedWork W2387467703 @default.
• W4313236507 hasRelatedWork W4233518984 @default.
• W4313236507 isParatext "false" @default.
• W4313236507 isRetracted "false" @default.
• W4313236507 workType "article" @default.