FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313236579> ?p ?o ?g. }

• W4313236579 abstract "Identifying cancer type-specific driver mutations is crucial for illuminating distinct pathologic mechanisms across various tumors and providing opportunities of patient-specific treatment. However, although many computational methods were developed to predict driver mutations in a type-specific manner, the methods still have room to improve. Here, we devise a novel feature based on sequence co-evolution analysis to identify cancer type-specific driver mutations and construct a machine learning (ML) model with state-of-the-art performance. Specifically, relying on 28 000 tumor samples across 66 cancer types, our ML framework outperformed current leading methods of detecting cancer driver mutations. Interestingly, the cancer mutations identified by sequence co-evolution feature are frequently observed in interfaces mediating tissue-specific protein-protein interactions that are known to associate with shaping tissue-specific oncogenesis. Moreover, we provide pre-calculated potential oncogenicity on available human proteins with prediction scores of all possible residue alterations through user-friendly website (http://sbi.postech.ac.kr/w/cancerCE). This work will facilitate the identification of cancer type-specific driver mutations in newly sequenced tumor samples." @default.
• W4313236579 created "2023-01-06" @default.
• W4313236579 creator A5002474894 @default.
• W4313236579 creator A5009259495 @default.
• W4313236579 creator A5015105642 @default.
• W4313236579 creator A5030484245 @default.
• W4313236579 creator A5033561338 @default.
• W4313236579 creator A5047859685 @default.
• W4313236579 date "2022-12-27" @default.
• W4313236579 modified "2023-10-14" @default.
• W4313236579 title "An evolution-based machine learning to identify cancer type-specific driver mutations" @default.
• W4313236579 cites W140255574 @default.
• W4313236579 cites W1861406683 @default.
• W4313236579 cites W1973686119 @default.
• W4313236579 cites W1984567848 @default.
• W4313236579 cites W2002645541 @default.
• W4313236579 cites W2009183764 @default.
• W4313236579 cites W2012034410 @default.
• W4313236579 cites W2019947024 @default.
• W4313236579 cites W2020699933 @default.
• W4313236579 cites W2032316709 @default.
• W4313236579 cites W2032927685 @default.
• W4313236579 cites W2043083737 @default.
• W4313236579 cites W2048248981 @default.
• W4313236579 cites W2059145105 @default.
• W4313236579 cites W2073220383 @default.
• W4313236579 cites W2076048958 @default.
• W4313236579 cites W2083045667 @default.
• W4313236579 cites W2088891952 @default.
• W4313236579 cites W2089335658 @default.
• W4313236579 cites W2096460732 @default.
• W4313236579 cites W2097113581 @default.
• W4313236579 cites W2099772372 @default.
• W4313236579 cites W2100867326 @default.
• W4313236579 cites W2101414350 @default.
• W4313236579 cites W2106799894 @default.
• W4313236579 cites W2115737495 @default.
• W4313236579 cites W2117646314 @default.
• W4313236579 cites W2121114445 @default.
• W4313236579 cites W2132926880 @default.
• W4313236579 cites W2137886330 @default.
• W4313236579 cites W2155051670 @default.
• W4313236579 cites W2158714788 @default.
• W4313236579 cites W2161732286 @default.
• W4313236579 cites W2169810209 @default.
• W4313236579 cites W2223119478 @default.
• W4313236579 cites W2245592118 @default.
• W4313236579 cites W2413084977 @default.
• W4313236579 cites W2423210081 @default.
• W4313236579 cites W2557187647 @default.
• W4313236579 cites W2591757282 @default.
• W4313236579 cites W2765253743 @default.
• W4313236579 cites W2782153240 @default.
• W4313236579 cites W2796408191 @default.
• W4313236579 cites W2868860358 @default.
• W4313236579 cites W2890223884 @default.
• W4313236579 cites W2905452503 @default.
• W4313236579 cites W2911964244 @default.
• W4313236579 cites W2921441004 @default.
• W4313236579 cites W2949706399 @default.
• W4313236579 cites W2950829512 @default.
• W4313236579 cites W2950945059 @default.
• W4313236579 cites W2953157847 @default.
• W4313236579 cites W2957157683 @default.
• W4313236579 cites W2982769402 @default.
• W4313236579 cites W3006500278 @default.
• W4313236579 cites W3009687973 @default.
• W4313236579 cites W3014461065 @default.
• W4313236579 cites W3047825284 @default.
• W4313236579 cites W3083914502 @default.
• W4313236579 cites W3133793061 @default.
• W4313236579 cites W3184087999 @default.
• W4313236579 doi "https://doi.org/10.1093/bib/bbac593" @default.
• W4313236579 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36575568" @default.
• W4313236579 hasPublicationYear "2022" @default.
• W4313236579 type Work @default.
• W4313236579 citedByCount "0" @default.
• W4313236579 crossrefType "journal-article" @default.
• W4313236579 hasAuthorship W4313236579A5002474894 @default.
• W4313236579 hasAuthorship W4313236579A5009259495 @default.
• W4313236579 hasAuthorship W4313236579A5015105642 @default.
• W4313236579 hasAuthorship W4313236579A5030484245 @default.
• W4313236579 hasAuthorship W4313236579A5033561338 @default.
• W4313236579 hasAuthorship W4313236579A5047859685 @default.
• W4313236579 hasConcept C104317684 @default.
• W4313236579 hasConcept C121608353 @default.
• W4313236579 hasConcept C138885662 @default.
• W4313236579 hasConcept C2776401178 @default.
• W4313236579 hasConcept C41008148 @default.
• W4313236579 hasConcept C41895202 @default.
• W4313236579 hasConcept C501734568 @default.
• W4313236579 hasConcept C54355233 @default.
• W4313236579 hasConcept C555283112 @default.
• W4313236579 hasConcept C60644358 @default.
• W4313236579 hasConcept C70721500 @default.
• W4313236579 hasConcept C86803240 @default.
• W4313236579 hasConceptScore W4313236579C104317684 @default.
• W4313236579 hasConceptScore W4313236579C121608353 @default.
• W4313236579 hasConceptScore W4313236579C138885662 @default.
• W4313236579 hasConceptScore W4313236579C2776401178 @default.

• next