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- W4313236784 abstract "Abstract DNA double‐strand breaks can seriously damage the genetic information that organisms depend on for survival and reproduction. Therefore, cells require a robust DNA damage response mechanism to repair the damaged DNA. Homologous recombination (HR) allows error‐free repair, which is key to maintaining genomic integrity. Long non‐coding RNAs (lncRNAs) are RNA molecules that are longer than 200 nucleotides. In recent years, a number of studies have found that lncRNAs can act as regulators of gene expression and DNA damage response mechanisms, including HR repair. Moreover, they have significant effects on the occurrence, development, invasion and metastasis of tumor cells, as well as the sensitivity of tumors to radiotherapy and chemotherapy. These studies have therefore begun to expose the great potential of lncRNAs for clinical applications. In this review, we focus on the regulatory roles of lncRNAs in HR repair." @default.
- W4313236784 created "2023-01-06" @default.
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- W4313236784 date "2022-12-28" @default.
- W4313236784 modified "2023-10-02" @default.
- W4313236784 title "The role and mechanism of long non‐coding RNAs in homologous recombination repair of radiation‐induced DNA damage" @default.
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- W4313236784 doi "https://doi.org/10.1002/jgm.3470" @default.
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