FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313236831> ?p ?o ?g. }

• W4313236831 abstract "Abstract Background Acquired chemo-drug resistance constantly led to the failure of chemotherapy for malignant cancers, consequently causing cancer relapse. Hence, identifying the biomarker of drug resistance is vital to improve the treatment efficacy in cancer. The clinical prognostic value of CYP24A1 remains inconclusive, hence we aim to evaluate the association between CYP24A1 and the drug resistance in cancer patients through a meta-analysis approach. Method Relevant studies detecting the expression or SNP of CYP24A1 in cancer patients up till May 2022 were systematically searched in four common scientific databases including PubMed, EMBASE, Cochrane library and ISI Web of Science. The pooled hazard ratios (HRs) indicating the ratio of hazard rate of survival time between CYP24A1 high population vs CYP24A1 low population were calculated. The pooled HRs and odds ratios (ORs) with 95% confidence intervals (CIs) were used to explore the association between CYP24A1’s expression or SNP with survival, metastasis, recurrence, and drug resistance in cancer patients. Result Fifteen studies were included in the meta-analysis after an initial screening according to the inclusion and exclusion criteria. There was a total of 3784 patients pooled from all the included studies. Results indicated that higher expression or SNP of CYP24A1 was significantly correlated with shorter survival time with pooled HRs (95% CI) of 1.21 (1.12, 1.31), metastasis with pooled ORs (95% CI) of 1.81 (1.11, 2.96), recurrence with pooled ORs (95% CI) of 2.14 (1.45, 3.18) and drug resistance with pooled HRs (95% CI) of 1.42 (1.17, 1.68). In the subgroup analysis, cancer type, treatment, ethnicity, and detection approach for CYP24A1 did not affect the significance of the association between CYP24A1 expression and poor prognosis. Conclusion Findings from our meta-analysis demonstrated that CYP24A1’s expression or SNP was correlated with cancer progression and drug resistance. Therefore, CYP24A1 could be a potential molecular marker for cancer resistance." @default.
• W4313236831 created "2023-01-06" @default.
• W4313236831 creator A5013230790 @default.
• W4313236831 creator A5016443996 @default.
• W4313236831 creator A5017557616 @default.
• W4313236831 creator A5020822126 @default.
• W4313236831 creator A5022056319 @default.
• W4313236831 creator A5063114912 @default.
• W4313236831 creator A5064519606 @default.
• W4313236831 creator A5064719218 @default.
• W4313236831 creator A5067212579 @default.
• W4313236831 creator A5067250819 @default.
• W4313236831 creator A5069431366 @default.
• W4313236831 creator A5070399019 @default.
• W4313236831 creator A5070507133 @default.
• W4313236831 creator A5083827884 @default.
• W4313236831 date "2022-12-16" @default.
• W4313236831 modified "2023-09-26" @default.
• W4313236831 title "Association of CYP24A1 with survival and drug resistance in clinical cancer patients: a meta-analysis" @default.
• W4313236831 cites W1480803244 @default.
• W4313236831 cites W1578023505 @default.
• W4313236831 cites W1844421042 @default.
• W4313236831 cites W1965943515 @default.
• W4313236831 cites W1976216662 @default.
• W4313236831 cites W1976776496 @default.
• W4313236831 cites W1990389642 @default.
• W4313236831 cites W2012382826 @default.
• W4313236831 cites W2016200167 @default.
• W4313236831 cites W2018730905 @default.
• W4313236831 cites W2026644677 @default.
• W4313236831 cites W2033830364 @default.
• W4313236831 cites W2035632263 @default.
• W4313236831 cites W2059205175 @default.
• W4313236831 cites W2059278457 @default.
• W4313236831 cites W2072096625 @default.
• W4313236831 cites W2075642745 @default.
• W4313236831 cites W2076811408 @default.
• W4313236831 cites W2076928852 @default.
• W4313236831 cites W2084949658 @default.
• W4313236831 cites W2087798593 @default.
• W4313236831 cites W2088095316 @default.
• W4313236831 cites W2097246433 @default.
• W4313236831 cites W2100836769 @default.
• W4313236831 cites W2102271210 @default.
• W4313236831 cites W2103119277 @default.
• W4313236831 cites W2108444198 @default.
• W4313236831 cites W2109191724 @default.
• W4313236831 cites W2116475791 @default.
• W4313236831 cites W2123667408 @default.
• W4313236831 cites W2125715541 @default.
• W4313236831 cites W2127154129 @default.
• W4313236831 cites W2129349477 @default.
• W4313236831 cites W2139806108 @default.
• W4313236831 cites W2144662506 @default.
• W4313236831 cites W2150530981 @default.
• W4313236831 cites W2150787678 @default.
• W4313236831 cites W2155430176 @default.
• W4313236831 cites W2157751466 @default.
• W4313236831 cites W2162741492 @default.
• W4313236831 cites W2166025830 @default.
• W4313236831 cites W2178702640 @default.
• W4313236831 cites W2333173774 @default.
• W4313236831 cites W2333334253 @default.
• W4313236831 cites W2344099442 @default.
• W4313236831 cites W2412212231 @default.
• W4313236831 cites W2538235319 @default.
• W4313236831 cites W2563244602 @default.
• W4313236831 cites W2593998160 @default.
• W4313236831 cites W2750450930 @default.
• W4313236831 cites W2750776344 @default.
• W4313236831 cites W2763731508 @default.
• W4313236831 cites W2802173235 @default.
• W4313236831 cites W2896625419 @default.
• W4313236831 cites W2916365527 @default.
• W4313236831 cites W2968903400 @default.
• W4313236831 cites W2976694805 @default.
• W4313236831 cites W2988773550 @default.
• W4313236831 cites W2992348665 @default.
• W4313236831 cites W2995007557 @default.
• W4313236831 cites W3000259610 @default.
• W4313236831 cites W3011173168 @default.
• W4313236831 cites W3028643844 @default.
• W4313236831 cites W3036213667 @default.
• W4313236831 cites W3046087118 @default.
• W4313236831 cites W3047648989 @default.
• W4313236831 cites W3084628403 @default.
• W4313236831 cites W3105370234 @default.
• W4313236831 cites W3135491144 @default.
• W4313236831 cites W3173512656 @default.
• W4313236831 cites W3210475192 @default.
• W4313236831 cites W4221015800 @default.
• W4313236831 cites W4247832872 @default.
• W4313236831 cites W4280505640 @default.
• W4313236831 cites W2755796637 @default.
• W4313236831 doi "https://doi.org/10.1186/s12885-022-10369-x" @default.
• W4313236831 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36527000" @default.
• W4313236831 hasPublicationYear "2022" @default.
• W4313236831 type Work @default.
• W4313236831 citedByCount "3" @default.
• W4313236831 countsByYear W43132368312023 @default.

• next