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- W4313236853 abstract "A key pathological event occurring in Parkinson's disease (PD) is the transneuronal spreading of alpha-synuclein (α-syn). Other hallmarks of PD include neurodegeneration, glial activation, and immune cell infiltration in susceptible brain regions. Although preclinical models can mimic most of the key characteristics of PD, it is crucial to know the biological bases of individual differences between them when choosing one over another, to ensure proper interpretation of the results and to positively influence the outcome of the experiments.This review provides an overview of current preclinical models actively used to study the interplay between α-syn pathology, neuroinflammation and immune response in PD but also to explore new potential preclinical models or emerging therapeutic strategies intended to fulfill the unmet medical needs in this disease. Lastly, this review also considers the current state of the ongoing clinical trials of new drugs designed to target these processes and delay the initiation or progression of the disease.Anti-inflammatory and immunomodulatory agents have been demonstrated to be very promising candidates for reducing disease progression; however, more efforts are needed to reduce the enormous gap between these and dopaminergic drugs, which have dominated the therapeutic market for the last sixty years." @default.
- W4313236853 created "2023-01-06" @default.
- W4313236853 creator A5082130741 @default.
- W4313236853 creator A5084740875 @default.
- W4313236853 creator A5089831492 @default.
- W4313236853 date "2022-12-28" @default.
- W4313236853 modified "2023-10-18" @default.
- W4313236853 title "Neuroinflammation, immune response and α-synuclein pathology: how animal models are helping us to connect dots" @default.
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