FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313236856> ?p ?o ?g. }

• W4313236856 endingPage "250" @default.
• W4313236856 startingPage "240" @default.
• W4313236856 abstract "Abstract Background One of the DSM‐5 criteria for Alcohol Use Disorder is continued alcohol consumption despite negative consequences. This has been modeled in mice using adulteration of alcohol solution with the bitter tastant quinine. Mice that continue to consume alcohol despite this adulteration are considered aversion resistant. The limited number of studies dissecting the underlying neuronal mechanisms of aversion‐resistant drinking behaviors used only male subjects. We have previously shown that female mice are more resistant to quinine adulteration of alcohol than males. Our aim here is to identify potential sex differences in neuronal activation that may underlie this behavior. Methods Male and female C57BL/6J mice were allowed continuous access to 20% alcohol in a two‐bottle choice procedure. To test aversion‐resistance, the alcohol was adulterated with increasing concentrations (0.03, 0.1, and 0.2 mM) of quinine hydrochloride. After consumption rates were calculated, brains were extracted to examine neuronal activation using Fos immunohistochemistry. Results We found that female mice suppressed their intake to a lesser extent than males when the alcohol solution was adulterated with quinine. Our Fos staining revealed three regions of interest that exhibit a sex difference during quinine‐adulterated alcohol drinking: the ventromedial prefrontal cortex (vmPFC), the posterior insular cortex (PIC), and the ventral tegmental area (VTA). Both the vmPFC and the PIC exhibited higher neuronal activation in males during quinine‐adulterated alcohol consumption. However, females showed higher Fos activation in the VTA during quinine‐adulterated alcohol consumption. Conclusions Females more readily exhibit aversion‐resistant alcohol intake than their male counterparts and exhibit some differences in neuronal activation patterns. We conclude that there are sex differences in neurocircuitry that may underlie compulsive drinking behaviors." @default.
• W4313236856 created "2023-01-06" @default.
• W4313236856 creator A5017144752 @default.
• W4313236856 creator A5028548607 @default.
• W4313236856 creator A5034794369 @default.
• W4313236856 creator A5038225701 @default.
• W4313236856 creator A5044678723 @default.
• W4313236856 date "2023-01-15" @default.
• W4313236856 modified "2023-09-27" @default.
• W4313236856 title "Sex differences in neuronal activation during aversion‐resistant alcohol consumption" @default.
• W4313236856 cites W1895471809 @default.
• W4313236856 cites W1962536263 @default.
• W4313236856 cites W1965232467 @default.
• W4313236856 cites W1975645388 @default.
• W4313236856 cites W1977137145 @default.
• W4313236856 cites W1978400943 @default.
• W4313236856 cites W1991603311 @default.
• W4313236856 cites W1993492805 @default.
• W4313236856 cites W1995497916 @default.
• W4313236856 cites W2004159545 @default.
• W4313236856 cites W2013016395 @default.
• W4313236856 cites W2049791338 @default.
• W4313236856 cites W2056516685 @default.
• W4313236856 cites W2073313025 @default.
• W4313236856 cites W2094614798 @default.
• W4313236856 cites W2100804779 @default.
• W4313236856 cites W2107258454 @default.
• W4313236856 cites W2124189011 @default.
• W4313236856 cites W2124669459 @default.
• W4313236856 cites W2184333478 @default.
• W4313236856 cites W2297010502 @default.
• W4313236856 cites W2331784877 @default.
• W4313236856 cites W2473866551 @default.
• W4313236856 cites W2513315503 @default.
• W4313236856 cites W2587859190 @default.
• W4313236856 cites W2643238975 @default.
• W4313236856 cites W2767502010 @default.
• W4313236856 cites W2793350608 @default.
• W4313236856 cites W2794319403 @default.
• W4313236856 cites W2871946062 @default.
• W4313236856 cites W2900828161 @default.
• W4313236856 cites W2923183989 @default.
• W4313236856 cites W2969542180 @default.
• W4313236856 cites W2970067111 @default.
• W4313236856 cites W2982552843 @default.
• W4313236856 cites W2985092233 @default.
• W4313236856 cites W2989731603 @default.
• W4313236856 cites W3003066715 @default.
• W4313236856 cites W3028697836 @default.
• W4313236856 cites W3030925002 @default.
• W4313236856 cites W3047712266 @default.
• W4313236856 cites W3122705991 @default.
• W4313236856 cites W3132052013 @default.
• W4313236856 cites W3146011145 @default.
• W4313236856 cites W3157214042 @default.
• W4313236856 cites W3193366375 @default.
• W4313236856 cites W3196076979 @default.
• W4313236856 cites W3197180249 @default.
• W4313236856 cites W3202729581 @default.
• W4313236856 cites W968389736 @default.
• W4313236856 doi "https://doi.org/10.1111/acer.15006" @default.
• W4313236856 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36575056" @default.
• W4313236856 hasPublicationYear "2023" @default.
• W4313236856 type Work @default.
• W4313236856 citedByCount "3" @default.
• W4313236856 countsByYear W43132368562023 @default.
• W4313236856 crossrefType "journal-article" @default.
• W4313236856 hasAuthorship W4313236856A5017144752 @default.
• W4313236856 hasAuthorship W4313236856A5028548607 @default.
• W4313236856 hasAuthorship W4313236856A5034794369 @default.
• W4313236856 hasAuthorship W4313236856A5038225701 @default.
• W4313236856 hasAuthorship W4313236856A5044678723 @default.
• W4313236856 hasBestOaLocation W43132368561 @default.
• W4313236856 hasConcept C134018914 @default.
• W4313236856 hasConcept C142724271 @default.
• W4313236856 hasConcept C15744967 @default.
• W4313236856 hasConcept C164742699 @default.
• W4313236856 hasConcept C169760540 @default.
• W4313236856 hasConcept C2777617192 @default.
• W4313236856 hasConcept C2778048844 @default.
• W4313236856 hasConcept C2780161600 @default.
• W4313236856 hasConcept C2781066024 @default.
• W4313236856 hasConcept C3019635848 @default.
• W4313236856 hasConcept C55493867 @default.
• W4313236856 hasConcept C71924100 @default.
• W4313236856 hasConcept C86803240 @default.
• W4313236856 hasConcept C8868529 @default.
• W4313236856 hasConceptScore W4313236856C134018914 @default.
• W4313236856 hasConceptScore W4313236856C142724271 @default.
• W4313236856 hasConceptScore W4313236856C15744967 @default.
• W4313236856 hasConceptScore W4313236856C164742699 @default.
• W4313236856 hasConceptScore W4313236856C169760540 @default.
• W4313236856 hasConceptScore W4313236856C2777617192 @default.
• W4313236856 hasConceptScore W4313236856C2778048844 @default.
• W4313236856 hasConceptScore W4313236856C2780161600 @default.
• W4313236856 hasConceptScore W4313236856C2781066024 @default.
• W4313236856 hasConceptScore W4313236856C3019635848 @default.
• W4313236856 hasConceptScore W4313236856C55493867 @default.

• next