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- W4313236866 abstract "Abstract Lipomas are slow growing benign fat tumors that develop in soft tissues of the mesoderm. Thus, the specific (dys‐)function of mesenchymal stem cells (MSCs) has been suggested in the development of lipomas, but details of the tumor pathogenesis remain unclear. Existing studies comparing stem cells from native adipose (adipose stem cells [ASCs]) and lipomatous tissues (LSCs) have reported contradicting findings. However, harvesting ASCs and LSCs from different individuals might have influenced proper comparison. Therefore, we aimed to characterize donor‐matched ASCs and LSCs to investigate metabolic activity, proliferation, capability for tri‐linear differentiation (chondrogenesis, adipogenesis, osteogenesis), and the secretome of mature adipocytes and lipomacytes. Both stem cell types did not differ in metabolic activity, but ASCs demonstrated stronger proliferation than LSCs. While there was no difference in proteoglycan accumulation during chondrogenic differentiation, adipogenesis was higher in ASCs, with more lipid vacuole formation. Conversely, LSCs showed increased osteogenesis by higher calcium deposition. Lipomacytes showed stronger secretory activity and released higher levels of certain adipokines. Our findings indicated that LSCs possessed important characteristics of MSCs, including ASCs. However, LSCs' low proliferation and adipogenic differentiation behavior did not appear to account for enhanced tissue proliferation, but the secretome of lipomacytes could contribute to lipomatous neoplasm." @default.
- W4313236866 created "2023-01-06" @default.
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- W4313236866 date "2022-12-28" @default.
- W4313236866 modified "2023-09-25" @default.
- W4313236866 title "Adipose and lipoma stem cells: A donor‐matched comparison" @default.
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- W4313236866 doi "https://doi.org/10.1002/cbf.3773" @default.
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