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- W4313236911 endingPage "1887" @default.
- W4313236911 startingPage "1887" @default.
- W4313236911 abstract "Intrinsically disordered proteins (IDPs) are important in both normal and disease states. Small molecules can be targeted to disordered regions, but we currently have only a limited understanding of the nature of small-molecule binding sites in IDPs. Here, we show that a minimal small-molecule binding sequence of eight contiguous residues derived from the Myc protein can be ported into a different disordered protein and recapitulate small-molecule binding activity in the new context. We also find that the residue immediately flanking the binding site can have opposing effects on small-molecule binding in the different disordered protein contexts. The results demonstrate that small-molecule binding sites can act modularly and are portable between disordered protein contexts but that residues outside of the minimal binding site can modulate binding affinity." @default.
- W4313236911 created "2023-01-06" @default.
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- W4313236911 date "2022-12-16" @default.
- W4313236911 modified "2023-10-18" @default.
- W4313236911 title "Portability of a Small-Molecule Binding Site between Disordered Proteins" @default.
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- W4313236911 doi "https://doi.org/10.3390/biom12121887" @default.
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