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• W4313237003 endingPage "2103" @default.
• W4313237003 startingPage "2095" @default.
• W4313237003 abstract "Objective Viral acute rhinosinusitis (ARS) is the leading cause of work and school absence and antibiotic over‐prescription. There are limited treatment options available to ameliorate the symptoms caused by viral ARS. We have previously demonstrated that topical adenosine treatment enhances mucociliary clearance in the sino‐nasal tract. Here, we assessed the therapeutic potential of topical adenosine in a mouse model of viral ARS. Methods The effect of topical adenosine on inflammatory response and mucin gene expression was examined in a mouse model of viral ARS induced by respiratory syncytial virus (RSV) nasal‐only infection. We also investigated the inflammatory effect of both endogenous and exogenous adenosine in the sino‐nasal tract. Results Topical adenosine significantly inhibited the expression of pro‐inflammatory cytokines, goblet hyperplasia, mucin expression, and cell damage in the nose of mice with viral ARS. This treatment did not prolong virus clearance. This inhibitory effect was primarily mediated by the A 2A adenosine receptor (AR). Although previous studies have shown that adenosine induces a robust inflammatory response in the lungs, neither endogenous nor exogenous adenosine produced inflammation in the sino‐nasal tract. Instead, exogenous adenosine inhibited the baseline expression of TNF and IL‐1β in the nose. Additionally, baseline expression of ARs was lower in the nose than that in the trachea and lungs. Conclusion We demonstrated that intranasal adenosine administration effectively decreased inflammation and mucus production in a mouse model of viral ARS. Level of Evidence N/A Laryngoscope , 133:2095–2103, 2023" @default.
• W4313237003 created "2023-01-06" @default.
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• W4313237003 date "2022-12-28" @default.
• W4313237003 modified "2023-10-15" @default.
• W4313237003 title "Topical Adenosine Inhibits Inflammation and Mucus Production in Viral Acute Rhinosinusitis" @default.
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• W4313237003 doi "https://doi.org/10.1002/lary.30541" @default.
• W4313237003 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36576070" @default.
• W4313237003 hasPublicationYear "2022" @default.
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