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- W4313237219 endingPage "199" @default.
- W4313237219 startingPage "191" @default.
- W4313237219 abstract "The Golgi apparatus modifies and transports secretory and membrane proteins. In some instances, the production of secretory and membrane proteins exceeds the capacity of the Golgi apparatus, including vesicle trafficking and the post-translational modification of macromolecules. These proteins are not modified or delivered appropriately due to insufficiency in the Golgi function. These conditions disturb Golgi homeostasis and induce a cellular condition known as Golgi stress, causing cells to activate the 'Golgi stress response,' which is a homeostatic process to increase the capacity of the Golgi based on cellular requirements. Since the Golgi functions are diverse, several response pathways involving TFE3, HSP47, CREB3, proteoglycan, mucin, MAPK/ETS, and PERK regulate the capacity of each Golgi function separately. Understanding the Golgi stress response is crucial for revealing the mechanisms underlying Golgi dynamics and its effect on human health because many signaling molecules are related to diseases, ranging from viral infections to fatal neurodegenerative diseases. Therefore, it is valuable to summarize and investigate the mechanisms underlying Golgi stress response in disease pathogenesis, as they may contribute to developing novel therapeutic strategies. In this review, we investigate the perturbations and stress signaling of the Golgi, as well as the therapeutic potentials of new strategies for treating Golgi stress-associated diseases." @default.
- W4313237219 created "2023-01-06" @default.
- W4313237219 creator A5025657856 @default.
- W4313237219 creator A5038588632 @default.
- W4313237219 creator A5064726267 @default.
- W4313237219 creator A5070889332 @default.
- W4313237219 creator A5074270134 @default.
- W4313237219 date "2022-04-30" @default.
- W4313237219 modified "2023-10-14" @default.
- W4313237219 title "Golgi Stress Response: New Insights into the Pathogenesis and Therapeutic Targets of Human Diseases" @default.
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- W4313237219 doi "https://doi.org/10.14348/molcells.2023.2152" @default.
- W4313237219 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36574967" @default.
- W4313237219 hasPublicationYear "2022" @default.