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- W4313237593 endingPage "89" @default.
- W4313237593 startingPage "71" @default.
- W4313237593 abstract "Adults with obesity may develop asthma that is ineffectively controlled by inhaled corticosteroids and long-acting beta-adrenoceptor agonists. Mechanistic and translational studies suggest that metabolic dysregulation that occurs with obesity, particularly hyperglycemia and insulin resistance, contributes to altered immune cell function and low-grade systemic inflammation. Importantly, in these cases, the same proinflammatory cytokines believed to contribute to insulin resistance may also be responsible for airway remodeling and hyperresponsiveness. In the past decade, new research has emerged assessing whether hypoglycemic therapies impact comorbid asthma as reflected by the incidence of asthma, asthma-related emergency department visits, asthma-related hospitalizations, and asthma-related exacerbations. The purpose of this review article is to discuss the mechanism of action, preclinical data, and existing clinical studies regarding the efficacy and safety of hypoglycemic therapies for adults with obesity and comorbid asthma." @default.
- W4313237593 created "2023-01-06" @default.
- W4313237593 creator A5005293011 @default.
- W4313237593 creator A5062765086 @default.
- W4313237593 creator A5067008487 @default.
- W4313237593 date "2022-12-27" @default.
- W4313237593 modified "2023-09-30" @default.
- W4313237593 title "Utility of Hypoglycemic Agents to Treat Asthma with Comorbid Obesity" @default.
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