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• W4313237611 abstract "AbstractBackground Survival after meningioma surgery is often reported with inadequate allowance for competing causes of death.Methods We processed the Système National des Données de Santé, the French administrative medical database to retrieve appropriate patients’ case of surgically treated meningiomas. The Pohar Perme relative survival (RS) method was implement.Results A total of 28,778 patients were identified between 2007 and 2017 of which 75% were female. Median age at surgery 59 years. Cranial convexity was the most common (24.7%) location and, benign meningioma represented 91.5% of all meningioma. Median follow-up was 3.5 years interquartile range [3.4–3.5]. At data collection, 2,232 patients were dead. The five-year survival relative to the expected survival of an age- and gender-matched French standard population was 96.2% 95% confidence interval (CI)[95.7–96.8]. Meningioma absolute excess risk of death was 973/100,000 person-years 95%CI[887–1068] (p< .001). The related standardised mortality ratio was 1.8 95%CI[1.7–1.9] (p< .001). In the adjusted model, male gender (hazard ratio [HR] =1.39, 95%CI[1.27–1.54], p< .001), age at surgery (HR=0.97, 95%CI[0.97–0.97], p < .001), type 2 neurofibromatosis (HR=2.95, 95%CI[1.95–4.46], p < .001), comorbidities HR=1.39, 95%CI[1.36–1.42], p < .001), location (HR=0.8, 95%CI[0.67–0.95], p= .0111), pre-operative embolization, (HR=1.3, 95%CI[1.08–1.56], p= .00507), cerebro-spinal fluid shunt, (HR=2.48, 95%CI[2.04–3.01], p < .001), atypical (HR=1.3, 95%CI [1.09–1.54], p= .00307) or malignant histology (HR=1.86, 95%CI[1.56–2.22], p< .001), redo surgery (HR=1.19, 95%CI[1.04–1.36], p= .0122) and radiotherapy (HR=1.43, 95%CI[1.26–1.62], p < .001) were established as independent predictors of RS.Conclusion This unique study highlights the excess mortality associated with meningioma disease. Many factors such as gender, age, location, histopathological grading, redo surgery influence the RS.Keywords: Meningiomarelative survivaloutcomehealthcare databasepredictors AcknowledgmentsMarjorie Boussac and Julius Kemme from the CNAM for their help in data extraction; Hugo Varet, Bioinformatics and Biostatistics HUB, Department of Computational Biology, Institut Pasteur, Paris, France; Jean-Philippe Jais, Université Paris Descartes – Hôpital universitaire Necker – Enfants Malades, Paris, France; Mrs. Segolène Van Outheusden, London, England, United Kingdom, for its manuscript review, English proofreading, grammar and spelling check.Ethical approvalThis study was conducted according to the ethical guidelines for epidemiological research in accordance with the ethical standards of the Helsinki Declaration (2008), to the French data protection authority (CNIL) an independent national ethical committee, authorisation number: 2008538; to the RECORD guidelines for studies conducted using routinely-collected health data and, according to the SAMPL Guidelines.Citation18,Citation19 Informed consent was not required due to the retrospective nature of the study and the use of anonymised data, in accordance with the European General Data Protection Regulation (GRPD EU 2016/679).Disclosure statementNo potential conflict of interest was reported by the author(s).Data availability statementRestricted, the authors do not have permission to share data.Code availabilityOn demand.Additional informationFundingNo funding was received for this research." @default.
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• W4313237611 date "2022-12-28" @default.
• W4313237611 modified "2023-10-02" @default.
• W4313237611 title "Relative survival after meningioma surgery. A French nationwide population-based cohort study" @default.
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• W4313237611 doi "https://doi.org/10.1080/02688697.2022.2159925" @default.
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