Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313237716> ?p ?o ?g. }
- W4313237716 abstract "Antioxidant natural products and their analogs especially phenolic compounds, exhibit diverse biological properties, including anti-inflammatory, antioxidant, and anticancer activities. Ginger which is widely used worldwide for various beneficial effects also contains several phenolic antioxidants, and 6-gingerol is one of the natural products studied extensively. However, the molecular mechanism of synthetically synthesized 6-gingerdione (compound 1) from 6-gingerol was not known. In this study, compound 1 and methylated 6-gingerdione (compound 2) were obtained semi synthetically from 6-gingerol. Compound 1 and 2 are subjected to SwissADME prediction. Then the protective effect of compound 1 was analyzed in 2 % EtOH induced HepG2 cells and zebrafish larvae. Hydroxyl and nitric oxide scavenging assays reveal that compound 1 showed more antioxidant activity than compound 2 at 50 μM. Moreover, compound 1 exhibited good anti-inflammatory activity via lipoxygenase inhibition and proteinase inhibition. Apoptosis and oxidative stress in HepG2 cells were induced by 2 % EtOH and treated with compound 1. Compound 1 significantly inhibited the EtOH induced nitric oxide production, apoptosis, and ROS generation in HepG2 cells. Encouraged by the in-vitro antioxidant and anti-inflammatory activities, compound 1 was then investigated for its protective effect in 2 % EtOH induced ALD zebrafish larva. Compound 1 protected the zebrafish larvae from liver injury by suppressing inflammatory (COX-2, TNF-α, and IL-1β) and lipogenic genes (C/EBP-α, SREBP1, and IL-1β) while upregulating the antioxidant gene. Our findings indicate that compound 1 synthesized from 6-gingerol ameliorated liver injury that likely, contributes to its potential antioxidant and anti-inflammatory properties." @default.
- W4313237716 created "2023-01-06" @default.
- W4313237716 creator A5007561749 @default.
- W4313237716 creator A5013772237 @default.
- W4313237716 creator A5018073786 @default.
- W4313237716 creator A5026107830 @default.
- W4313237716 creator A5044024787 @default.
- W4313237716 creator A5066172183 @default.
- W4313237716 date "2022-12-27" @default.
- W4313237716 modified "2023-10-02" @default.
- W4313237716 title "6‐Gingerdione Reduces Apoptotic Conditions in HepG2 Cells and Inhibits Inflammatory Cytokine Gene Expression in Alcoholic Liver Injured Zebrafish Larvae" @default.
- W4313237716 cites W1968037251 @default.
- W4313237716 cites W1981280200 @default.
- W4313237716 cites W1987478588 @default.
- W4313237716 cites W1996666440 @default.
- W4313237716 cites W2004572248 @default.
- W4313237716 cites W2015045330 @default.
- W4313237716 cites W2018600598 @default.
- W4313237716 cites W2029625413 @default.
- W4313237716 cites W2043535635 @default.
- W4313237716 cites W2044381985 @default.
- W4313237716 cites W2056564326 @default.
- W4313237716 cites W2081828123 @default.
- W4313237716 cites W2088866343 @default.
- W4313237716 cites W2091906087 @default.
- W4313237716 cites W2096795975 @default.
- W4313237716 cites W2097500515 @default.
- W4313237716 cites W2102263585 @default.
- W4313237716 cites W2104608678 @default.
- W4313237716 cites W2107277218 @default.
- W4313237716 cites W2131004746 @default.
- W4313237716 cites W2134285628 @default.
- W4313237716 cites W2164158043 @default.
- W4313237716 cites W2188121313 @default.
- W4313237716 cites W2207048478 @default.
- W4313237716 cites W2281119349 @default.
- W4313237716 cites W2431103171 @default.
- W4313237716 cites W2519786994 @default.
- W4313237716 cites W2754275543 @default.
- W4313237716 cites W2766321482 @default.
- W4313237716 cites W2941383652 @default.
- W4313237716 cites W2963306172 @default.
- W4313237716 cites W2989982111 @default.
- W4313237716 cites W3020300348 @default.
- W4313237716 cites W3026631899 @default.
- W4313237716 cites W3050451847 @default.
- W4313237716 cites W3083800980 @default.
- W4313237716 cites W3087288597 @default.
- W4313237716 cites W3108593759 @default.
- W4313237716 cites W3120791181 @default.
- W4313237716 cites W3126247219 @default.
- W4313237716 cites W3155488827 @default.
- W4313237716 cites W3183160797 @default.
- W4313237716 cites W3185952217 @default.
- W4313237716 cites W3191278140 @default.
- W4313237716 cites W3203716732 @default.
- W4313237716 cites W3208997582 @default.
- W4313237716 cites W3209750750 @default.
- W4313237716 cites W4206296618 @default.
- W4313237716 cites W4207035961 @default.
- W4313237716 cites W4213002856 @default.
- W4313237716 cites W4214938331 @default.
- W4313237716 cites W4221010265 @default.
- W4313237716 cites W4226026930 @default.
- W4313237716 cites W4280493189 @default.
- W4313237716 cites W4293247451 @default.
- W4313237716 doi "https://doi.org/10.1002/cbdv.202200959" @default.
- W4313237716 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36574474" @default.
- W4313237716 hasPublicationYear "2022" @default.
- W4313237716 type Work @default.
- W4313237716 citedByCount "2" @default.
- W4313237716 countsByYear W43132377162023 @default.
- W4313237716 crossrefType "journal-article" @default.
- W4313237716 hasAuthorship W4313237716A5007561749 @default.
- W4313237716 hasAuthorship W4313237716A5013772237 @default.
- W4313237716 hasAuthorship W4313237716A5018073786 @default.
- W4313237716 hasAuthorship W4313237716A5026107830 @default.
- W4313237716 hasAuthorship W4313237716A5044024787 @default.
- W4313237716 hasAuthorship W4313237716A5066172183 @default.
- W4313237716 hasConcept C104317684 @default.
- W4313237716 hasConcept C178790620 @default.
- W4313237716 hasConcept C185592680 @default.
- W4313237716 hasConcept C190283241 @default.
- W4313237716 hasConcept C2776151105 @default.
- W4313237716 hasConcept C2776878037 @default.
- W4313237716 hasConcept C2778004101 @default.
- W4313237716 hasConcept C2779703632 @default.
- W4313237716 hasConcept C519581460 @default.
- W4313237716 hasConcept C55493867 @default.
- W4313237716 hasConcept C86803240 @default.
- W4313237716 hasConcept C98274493 @default.
- W4313237716 hasConceptScore W4313237716C104317684 @default.
- W4313237716 hasConceptScore W4313237716C178790620 @default.
- W4313237716 hasConceptScore W4313237716C185592680 @default.
- W4313237716 hasConceptScore W4313237716C190283241 @default.
- W4313237716 hasConceptScore W4313237716C2776151105 @default.
- W4313237716 hasConceptScore W4313237716C2776878037 @default.
- W4313237716 hasConceptScore W4313237716C2778004101 @default.
- W4313237716 hasConceptScore W4313237716C2779703632 @default.
- W4313237716 hasConceptScore W4313237716C519581460 @default.