Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313238912> ?p ?o ?g. }
- W4313238912 endingPage "3109" @default.
- W4313238912 startingPage "3100" @default.
- W4313238912 abstract "Phosphorene, a novel member of the two-dimensional nanomaterial family, has demonstrated great potential in biomedical applications, such as photothermal therapy, drug delivery and antibacterial. However, phosphorene is unstable and easily oxidized in an aerobic environment. In this paper, using larger-scale molecular dynamics simulations, we investigated the disruption of phosphorene oxide (PO) to the structure of a model protein, villin headpiece subdomain (HP35). It shows that the disruption of PO nanosheets to the protein structure is enhanced with increasing oxidation concentration of PO, while PO's oxidation mode has very little effect on the PO-HP35 interaction. PO with a low oxidation concentration has certain biocompatibility to HP35. Oxygen atoms filling into the groove region in the puckered surface of phosphorene enhance the dispersion interaction between phosphorene and HP35, which enhances the disruption of phosphorene to the structure of HP35. Compared with the dispersion interaction, the electrostatic interaction between PO and the protein has a negligible effect on the structural damage of HP35. These findings might shed light on the biological toxicity of PO nanosheets and would be helpful for future potential biomedical applications of PO nanosheets, such as nanodrugs and antibacterial agents." @default.
- W4313238912 created "2023-01-06" @default.
- W4313238912 creator A5018682392 @default.
- W4313238912 creator A5036970085 @default.
- W4313238912 creator A5041250686 @default.
- W4313238912 creator A5047215719 @default.
- W4313238912 creator A5063381843 @default.
- W4313238912 creator A5071286986 @default.
- W4313238912 creator A5079550294 @default.
- W4313238912 creator A5084391733 @default.
- W4313238912 date "2023-01-01" @default.
- W4313238912 modified "2023-09-28" @default.
- W4313238912 title "Revealing the biotoxicity of phosphorene oxide nanosheets based on the villin headpiece" @default.
- W4313238912 cites W1596779608 @default.
- W4313238912 cites W1603084134 @default.
- W4313238912 cites W1774122075 @default.
- W4313238912 cites W1849598006 @default.
- W4313238912 cites W1919158486 @default.
- W4313238912 cites W1965200769 @default.
- W4313238912 cites W1966743338 @default.
- W4313238912 cites W1984306479 @default.
- W4313238912 cites W2006105172 @default.
- W4313238912 cites W2008708467 @default.
- W4313238912 cites W2009452804 @default.
- W4313238912 cites W2009924367 @default.
- W4313238912 cites W2016343354 @default.
- W4313238912 cites W2024227324 @default.
- W4313238912 cites W2029281675 @default.
- W4313238912 cites W2029667189 @default.
- W4313238912 cites W2033399478 @default.
- W4313238912 cites W2035266068 @default.
- W4313238912 cites W2038853976 @default.
- W4313238912 cites W2041311241 @default.
- W4313238912 cites W2056612033 @default.
- W4313238912 cites W2056848862 @default.
- W4313238912 cites W2067174909 @default.
- W4313238912 cites W2069123478 @default.
- W4313238912 cites W2075460992 @default.
- W4313238912 cites W2084080597 @default.
- W4313238912 cites W2088034301 @default.
- W4313238912 cites W2108637237 @default.
- W4313238912 cites W2150315430 @default.
- W4313238912 cites W2151516307 @default.
- W4313238912 cites W2152259048 @default.
- W4313238912 cites W2154794547 @default.
- W4313238912 cites W2158703578 @default.
- W4313238912 cites W2160544821 @default.
- W4313238912 cites W2174451920 @default.
- W4313238912 cites W2184609107 @default.
- W4313238912 cites W2196734670 @default.
- W4313238912 cites W2267667936 @default.
- W4313238912 cites W2288533301 @default.
- W4313238912 cites W2399945589 @default.
- W4313238912 cites W2513787064 @default.
- W4313238912 cites W2559999041 @default.
- W4313238912 cites W2561206858 @default.
- W4313238912 cites W2585161153 @default.
- W4313238912 cites W2782504069 @default.
- W4313238912 cites W2808243369 @default.
- W4313238912 cites W2945928565 @default.
- W4313238912 cites W2963572698 @default.
- W4313238912 cites W2969298906 @default.
- W4313238912 cites W3000176093 @default.
- W4313238912 cites W3001674846 @default.
- W4313238912 cites W3003900509 @default.
- W4313238912 cites W3011196961 @default.
- W4313238912 cites W3099359162 @default.
- W4313238912 cites W3104801196 @default.
- W4313238912 cites W3121237535 @default.
- W4313238912 cites W3135767903 @default.
- W4313238912 cites W4211044073 @default.
- W4313238912 cites W4241885018 @default.
- W4313238912 cites W4283364950 @default.
- W4313238912 cites W4308686540 @default.
- W4313238912 cites W4378736302 @default.
- W4313238912 doi "https://doi.org/10.1039/d2cp04080h" @default.
- W4313238912 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36621815" @default.
- W4313238912 hasPublicationYear "2023" @default.
- W4313238912 type Work @default.
- W4313238912 citedByCount "0" @default.
- W4313238912 crossrefType "journal-article" @default.
- W4313238912 hasAuthorship W4313238912A5018682392 @default.
- W4313238912 hasAuthorship W4313238912A5036970085 @default.
- W4313238912 hasAuthorship W4313238912A5041250686 @default.
- W4313238912 hasAuthorship W4313238912A5047215719 @default.
- W4313238912 hasAuthorship W4313238912A5063381843 @default.
- W4313238912 hasAuthorship W4313238912A5071286986 @default.
- W4313238912 hasAuthorship W4313238912A5079550294 @default.
- W4313238912 hasAuthorship W4313238912A5084391733 @default.
- W4313238912 hasConcept C120665830 @default.
- W4313238912 hasConcept C121332964 @default.
- W4313238912 hasConcept C127413603 @default.
- W4313238912 hasConcept C138631740 @default.
- W4313238912 hasConcept C147597530 @default.
- W4313238912 hasConcept C159467904 @default.
- W4313238912 hasConcept C171250308 @default.
- W4313238912 hasConcept C177562468 @default.
- W4313238912 hasConcept C178790620 @default.