Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313244517> ?p ?o ?g. }
- W4313244517 endingPage "157" @default.
- W4313244517 startingPage "157" @default.
- W4313244517 abstract "Natural products (NPs) have historically played a primary role in the discovery of small-molecule drugs. However, due to the advent of other methodologies and the drawbacks of NPs, the pharmaceutical industry has largely declined in interest regarding the screening of new drugs from NPs since 2000. There are many technical bottlenecks to quickly obtaining new bioactive NPs on a large scale, which has made NP-based drug discovery very time-consuming, and the first thorny problem faced by researchers is how to dereplicate NPs from crude extracts. Remarkably, with the rapid development of omics, analytical instrumentation, and artificial intelligence technology, in 2012, an efficient approach, known as tandem mass spectrometry (MS/MS)-based molecular networking (MN) analysis, was developed to avoid the rediscovery of known compounds from the complex natural mixtures. Then, in the past decade, based on the classical MN (CLMN), feature-based MN (FBMN), ion identity MN (IIMN), building blocks-based molecular network (BBMN), substructure-based MN (MS2LDA), and bioactivity-based MN (BMN) methods have been presented. In this paper, we review the basic principles, general workflow, and application examples of the methods mentioned above, to further the research and applications of these methods." @default.
- W4313244517 created "2023-01-06" @default.
- W4313244517 creator A5002318539 @default.
- W4313244517 creator A5013424533 @default.
- W4313244517 creator A5036623415 @default.
- W4313244517 creator A5059290439 @default.
- W4313244517 creator A5063784893 @default.
- W4313244517 creator A5068630235 @default.
- W4313244517 creator A5078536750 @default.
- W4313244517 creator A5079878207 @default.
- W4313244517 creator A5080921318 @default.
- W4313244517 creator A5090535728 @default.
- W4313244517 date "2022-12-24" @default.
- W4313244517 modified "2023-10-01" @default.
- W4313244517 title "MS/MS-Based Molecular Networking: An Efficient Approach for Natural Products Dereplication" @default.
- W4313244517 cites W1488520384 @default.
- W4313244517 cites W1964408683 @default.
- W4313244517 cites W1971605716 @default.
- W4313244517 cites W1989299822 @default.
- W4313244517 cites W2001155120 @default.
- W4313244517 cites W2005326953 @default.
- W4313244517 cites W2020257352 @default.
- W4313244517 cites W2041620837 @default.
- W4313244517 cites W2074890788 @default.
- W4313244517 cites W2087774414 @default.
- W4313244517 cites W2140391185 @default.
- W4313244517 cites W2144803530 @default.
- W4313244517 cites W2153478782 @default.
- W4313244517 cites W2159675211 @default.
- W4313244517 cites W2161671078 @default.
- W4313244517 cites W2179948434 @default.
- W4313244517 cites W2283606770 @default.
- W4313244517 cites W2331343529 @default.
- W4313244517 cites W2429635451 @default.
- W4313244517 cites W2504691963 @default.
- W4313244517 cites W2508870274 @default.
- W4313244517 cites W2510334816 @default.
- W4313244517 cites W2513161319 @default.
- W4313244517 cites W2517883571 @default.
- W4313244517 cites W2551876238 @default.
- W4313244517 cites W2556797268 @default.
- W4313244517 cites W2582895757 @default.
- W4313244517 cites W2611021352 @default.
- W4313244517 cites W2626886916 @default.
- W4313244517 cites W2748850348 @default.
- W4313244517 cites W2776498066 @default.
- W4313244517 cites W2790225116 @default.
- W4313244517 cites W2790648044 @default.
- W4313244517 cites W2800712778 @default.
- W4313244517 cites W2895176645 @default.
- W4313244517 cites W2897178933 @default.
- W4313244517 cites W2901499404 @default.
- W4313244517 cites W2901755966 @default.
- W4313244517 cites W2908998505 @default.
- W4313244517 cites W2909586457 @default.
- W4313244517 cites W2913149564 @default.
- W4313244517 cites W2917928050 @default.
- W4313244517 cites W2932396318 @default.
- W4313244517 cites W2941665192 @default.
- W4313244517 cites W2942621872 @default.
- W4313244517 cites W2944456017 @default.
- W4313244517 cites W2947129631 @default.
- W4313244517 cites W2949780892 @default.
- W4313244517 cites W2969117557 @default.
- W4313244517 cites W3000274020 @default.
- W4313244517 cites W3000435127 @default.
- W4313244517 cites W3006044405 @default.
- W4313244517 cites W3011366455 @default.
- W4313244517 cites W3015356575 @default.
- W4313244517 cites W3021920958 @default.
- W4313244517 cites W3025883815 @default.
- W4313244517 cites W3030363843 @default.
- W4313244517 cites W3042647132 @default.
- W4313244517 cites W3047040580 @default.
- W4313244517 cites W3080668573 @default.
- W4313244517 cites W3080789666 @default.
- W4313244517 cites W3113803919 @default.
- W4313244517 cites W3128485166 @default.
- W4313244517 cites W3129424480 @default.
- W4313244517 cites W3159783121 @default.
- W4313244517 cites W3161074857 @default.
- W4313244517 cites W3167479850 @default.
- W4313244517 cites W3174482775 @default.
- W4313244517 cites W3174556253 @default.
- W4313244517 cites W3176450507 @default.
- W4313244517 cites W3182055317 @default.
- W4313244517 cites W3196903026 @default.
- W4313244517 cites W3202609363 @default.
- W4313244517 cites W3209680996 @default.
- W4313244517 cites W3210135519 @default.
- W4313244517 cites W4205379795 @default.
- W4313244517 cites W4205881120 @default.
- W4313244517 cites W4223462569 @default.
- W4313244517 cites W4223990414 @default.
- W4313244517 cites W4244913122 @default.
- W4313244517 cites W4281625382 @default.
- W4313244517 cites W4282600408 @default.
- W4313244517 cites W4283328447 @default.