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• W4313244598 endingPage "287" @default.
• W4313244598 startingPage "287" @default.
• W4313244598 abstract "Although progressive wasting and weakness of respiratory muscles are the prominent hallmarks of Duchenne muscular dystrophy (DMD) and long-COVID (also referred as the post-acute sequelae of COVID-19 syndrome); however, the underlying mechanism(s) leading to respiratory failure in both conditions remain unclear. We put together the latest relevant literature to further understand the plausible mechanism(s) behind diaphragm malfunctioning in COVID-19 and DMD conditions. Previously, we have shown the role of matrix metalloproteinase-9 (MMP9) in skeletal muscle fibrosis via a substantial increase in the levels of tumor necrosis factor-α (TNF-α) employing a DMD mouse model that was crossed-bred with MMP9-knockout (MMP9-KO or MMP9-/-) strain. Interestingly, recent observations from clinical studies show a robust increase in neopterin (NPT) levels during COVID-19 which is often observed in patients having DMD. What seems to be common in both (DMD and COVID-19) is the involvement of neopterin (NPT). We know that NPT is generated by activated white blood cells (WBCs) especially the M1 macrophages in response to inducible nitric oxide synthase (iNOS), tetrahydrobiopterin (BH4), and tetrahydrofolate (FH4) pathways, i.e., folate one-carbon metabolism (FOCM) in conjunction with epigenetics underpinning as an immune surveillance protection. Studies from our laboratory, and others researching DMD and the genetically engineered humanized (hACE2) mice that were administered with the spike protein (SP) of SARS-CoV-2 revealed an increase in the levels of NPT, TNF-α, HDAC, IL-1β, CD147, and MMP9 in the lung tissue of the animals that were subsequently accompanied by fibrosis of the diaphragm depicting a decreased oscillation phenotype. Therefore, it is of interest to understand how regulatory processes such as epigenetics involvement affect DNMT, HDAC, MTHFS, and iNOS that help generate NPT in the long-COVID patients." @default.
• W4313244598 created "2023-01-06" @default.
• W4313244598 creator A5003454740 @default.
• W4313244598 creator A5005647791 @default.
• W4313244598 creator A5037440323 @default.
• W4313244598 creator A5050842686 @default.
• W4313244598 creator A5057602157 @default.
• W4313244598 creator A5074172964 @default.
• W4313244598 creator A5087487562 @default.
• W4313244598 date "2022-12-24" @default.
• W4313244598 modified "2023-10-18" @default.
• W4313244598 title "COVID-19 Mimics Pulmonary Dysfunction in Muscular Dystrophy as a Post-Acute Syndrome in Patients" @default.
• W4313244598 cites W1864325817 @default.
• W4313244598 cites W1975377204 @default.
• W4313244598 cites W1977204209 @default.
• W4313244598 cites W1981427482 @default.
• W4313244598 cites W1987244729 @default.
• W4313244598 cites W1996100466 @default.
• W4313244598 cites W2006818944 @default.
• W4313244598 cites W2009769042 @default.
• W4313244598 cites W2029275439 @default.
• W4313244598 cites W2041059925 @default.
• W4313244598 cites W2045006694 @default.
• W4313244598 cites W2047826277 @default.
• W4313244598 cites W2048674504 @default.
• W4313244598 cites W2067660687 @default.
• W4313244598 cites W2068989465 @default.
• W4313244598 cites W2071298886 @default.
• W4313244598 cites W2074039400 @default.
• W4313244598 cites W2075207246 @default.
• W4313244598 cites W2095065732 @default.
• W4313244598 cites W2100596020 @default.
• W4313244598 cites W2103257623 @default.
• W4313244598 cites W2105034643 @default.
• W4313244598 cites W2150697205 @default.
• W4313244598 cites W2155111071 @default.
• W4313244598 cites W2165983791 @default.
• W4313244598 cites W2175794645 @default.
• W4313244598 cites W2251029942 @default.
• W4313244598 cites W2462773201 @default.
• W4313244598 cites W2491377505 @default.
• W4313244598 cites W2493461540 @default.
• W4313244598 cites W2567545900 @default.
• W4313244598 cites W2605243671 @default.
• W4313244598 cites W2736908489 @default.
• W4313244598 cites W2738066453 @default.
• W4313244598 cites W2777665100 @default.
• W4313244598 cites W2791700418 @default.
• W4313244598 cites W2791773154 @default.
• W4313244598 cites W2804669464 @default.
• W4313244598 cites W2804814098 @default.
• W4313244598 cites W2805024462 @default.
• W4313244598 cites W2884412680 @default.
• W4313244598 cites W2947702218 @default.
• W4313244598 cites W2952013696 @default.
• W4313244598 cites W2958001455 @default.
• W4313244598 cites W2969750300 @default.
• W4313244598 cites W2982361459 @default.
• W4313244598 cites W3010196267 @default.
• W4313244598 cites W3019124105 @default.
• W4313244598 cites W3027140293 @default.
• W4313244598 cites W3036781420 @default.
• W4313244598 cites W3041596017 @default.
• W4313244598 cites W3045282623 @default.
• W4313244598 cites W3049355626 @default.
• W4313244598 cites W3092436514 @default.
• W4313244598 cites W3092500182 @default.
• W4313244598 cites W3097650039 @default.
• W4313244598 cites W3107341499 @default.
• W4313244598 cites W3123471531 @default.
• W4313244598 cites W3130118028 @default.
• W4313244598 cites W3131413258 @default.
• W4313244598 cites W3131782536 @default.
• W4313244598 cites W3141888024 @default.
• W4313244598 cites W3150777598 @default.
• W4313244598 cites W3157787744 @default.
• W4313244598 cites W3169055556 @default.
• W4313244598 cites W3172217853 @default.
• W4313244598 cites W3186095213 @default.
• W4313244598 cites W3195657227 @default.
• W4313244598 cites W3209719885 @default.
• W4313244598 cites W4200283467 @default.
• W4313244598 cites W4200619235 @default.
• W4313244598 cites W4212799643 @default.
• W4313244598 cites W4220711760 @default.
• W4313244598 cites W4220779043 @default.
• W4313244598 cites W4226106435 @default.
• W4313244598 cites W4280638288 @default.
• W4313244598 cites W4281926227 @default.
• W4313244598 cites W4283262724 @default.
• W4313244598 cites W4284676906 @default.
• W4313244598 cites W4285676616 @default.
• W4313244598 cites W4285728655 @default.
• W4313244598 cites W4285793875 @default.
• W4313244598 cites W4285999566 @default.
• W4313244598 cites W4286560523 @default.
• W4313244598 cites W4290467222 @default.
• W4313244598 cites W4290599747 @default.

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