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- W4313244961 abstract "The emergence of multidrug-resistant (MDR) pathogens and the gradual depletion of available antibiotics have exacerbated the need for novel antimicrobial agents with minimal toxicity. Herein, we report functionally substituted pyridine carbohydrazide with remarkable antimicrobial effect on multi-drug resistant strains. In the series, compound 6 had potent activity against four MDR strains of Candida spp., with minimum inhibitory concentration (MIC) values being in the range of 16–24 µg/mL and percentage inhibition up to 92.57%, which was exceptional when compared to broad-spectrum antifungal drug fluconazole (MIC = 20 µg/mL, 81.88% inhibition). Substitution of the octyl chain in 6 with a shorter butyl chain resulted in a significant anti-bacterial effect of 4 against Pseudomonas aeruginosa (ATCC 27853), the MIC value being 2-fold superior to the standard combination of ampicillin/cloxacillin. Time-kill kinetics assays were used to discern the efficacy and pharmacodynamics of the potent compounds. Further, hemolysis tests confirmed that both compounds had better safety profiles than the standard drugs. Besides, molecular docking simulations were used to further explore their mode of interaction with target proteins. Overall results suggest that these compounds have the potential to become promising antimicrobial drugs against MDR strains." @default.
- W4313244961 created "2023-01-06" @default.
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- W4313244961 date "2022-12-26" @default.
- W4313244961 modified "2023-10-17" @default.
- W4313244961 title "Designing Functionally Substituted Pyridine-Carbohydrazides for Potent Antibacterial and Devouring Antifungal Effect on Multidrug Resistant (MDR) Strains" @default.
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- W4313244961 cites W1980076653 @default.
- W4313244961 cites W1993989420 @default.
- W4313244961 cites W1998548768 @default.
- W4313244961 cites W2004237531 @default.
- W4313244961 cites W2012134293 @default.
- W4313244961 cites W2014578817 @default.
- W4313244961 cites W2015956861 @default.
- W4313244961 cites W2022451274 @default.
- W4313244961 cites W2031443046 @default.
- W4313244961 cites W2047640613 @default.
- W4313244961 cites W2050080237 @default.
- W4313244961 cites W2053245283 @default.
- W4313244961 cites W2066307216 @default.
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- W4313244961 cites W2111439633 @default.
- W4313244961 cites W2113339063 @default.
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- W4313244961 cites W2148266917 @default.
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- W4313244961 cites W2157428610 @default.
- W4313244961 cites W2166909888 @default.
- W4313244961 cites W2172046963 @default.
- W4313244961 cites W2270023047 @default.
- W4313244961 cites W2306956788 @default.
- W4313244961 cites W2470559093 @default.
- W4313244961 cites W2553019514 @default.
- W4313244961 cites W2564139655 @default.
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- W4313244961 cites W2911640461 @default.
- W4313244961 cites W2949709354 @default.
- W4313244961 cites W2954295861 @default.
- W4313244961 cites W3035000959 @default.
- W4313244961 cites W3044909248 @default.
- W4313244961 cites W3045708299 @default.
- W4313244961 cites W3047157985 @default.
- W4313244961 cites W3080095784 @default.
- W4313244961 cites W3129897365 @default.
- W4313244961 cites W3135118388 @default.
- W4313244961 cites W3159592417 @default.
- W4313244961 cites W3196552365 @default.
- W4313244961 cites W3204655189 @default.
- W4313244961 cites W3205136031 @default.
- W4313244961 cites W4200240434 @default.
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- W4313244961 cites W4210473994 @default.
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- W4313244961 doi "https://doi.org/10.3390/molecules28010212" @default.
- W4313244961 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36615406" @default.
- W4313244961 hasPublicationYear "2022" @default.
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