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- W4313245005 startingPage "80" @default.
- W4313245005 abstract "Apixaban (Apx), an oral anticoagulant drug, is a direct factor Xa inhibitor for the prophylaxis against venous thromboembolism. Apx has limited oral bioavailability and poor water solubility. The goal of this study was to improve the formulation of an Apx-loaded nanostructured lipid carrier (NLC) to increase its bioavailability and effectiveness. As solid lipid, liquid lipid, hydrophilic, and lipophilic stabilizers, stearic acid, oleic acid, Tween 80, and lecithin were used, respectively. Utilizing Box–Behnken design, the effects of three factors on NLC particle size (Y1), zeta potential (Y2), and entrapment efficiency percent (Y3) were examined and optimized. The optimized formula was prepared, characterized, morphologically studied, and pharmacokinetically and pharmacodynamically assessed. The observed responses of the optimized Apx formula were 315.2 nm, −43.4 mV, and 89.84% for Y1, Y2, and Y3, respectively. Electron microscopy revealed the homogenous spherical shape of the NLC particles. The in vivo pharmacokinetic study conducted in male Wistar rats displayed an increase in AUC and Cmax by 8 and 2.67 folds, respectively, compared to oral Apx suspension. Moreover, the half-life was increased by 1.94 folds, and clearance was diminished by about 8 folds, which makes the NLC formula a promising sustained release system. Interestingly, the pharmacodynamic results displayed the superior effect of the optimized formula over the drug suspension with prolongation in the cuticle bleeding time. Moreover, both prothrombin time and activated partial thromboplastin time are significantly increased. So, incorporating Apx in an NLC formula significantly enhanced its oral bioavailability and pharmacodynamic activity." @default.
- W4313245005 created "2023-01-06" @default.
- W4313245005 creator A5003231547 @default.
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- W4313245005 creator A5035959895 @default.
- W4313245005 creator A5065965323 @default.
- W4313245005 creator A5087142985 @default.
- W4313245005 date "2022-12-27" @default.
- W4313245005 modified "2023-09-25" @default.
- W4313245005 title "Tailoring Apixaban in Nanostructured Lipid Carrier Enhancing Its Oral Bioavailability and Anticoagulant Activity" @default.
- W4313245005 cites W1133323881 @default.
- W4313245005 cites W1479868810 @default.
- W4313245005 cites W1503033818 @default.
- W4313245005 cites W1568662837 @default.
- W4313245005 cites W1591205163 @default.
- W4313245005 cites W1971848215 @default.
- W4313245005 cites W1971907096 @default.
- W4313245005 cites W1974166640 @default.
- W4313245005 cites W1976779766 @default.
- W4313245005 cites W1977143275 @default.
- W4313245005 cites W1978778227 @default.
- W4313245005 cites W1980802044 @default.
- W4313245005 cites W1987688990 @default.
- W4313245005 cites W1993788795 @default.
- W4313245005 cites W2005243147 @default.
- W4313245005 cites W2012100899 @default.
- W4313245005 cites W2013710547 @default.
- W4313245005 cites W2013723299 @default.
- W4313245005 cites W2025722135 @default.
- W4313245005 cites W2033779050 @default.
- W4313245005 cites W2037646770 @default.
- W4313245005 cites W2038019940 @default.
- W4313245005 cites W2043178776 @default.
- W4313245005 cites W2048580091 @default.
- W4313245005 cites W2050992159 @default.
- W4313245005 cites W2056812747 @default.
- W4313245005 cites W2066947166 @default.
- W4313245005 cites W2073983855 @default.
- W4313245005 cites W2074887365 @default.
- W4313245005 cites W2079141522 @default.
- W4313245005 cites W2080025116 @default.
- W4313245005 cites W2085692671 @default.
- W4313245005 cites W2088944564 @default.
- W4313245005 cites W2089923109 @default.
- W4313245005 cites W2092451289 @default.
- W4313245005 cites W2094800902 @default.
- W4313245005 cites W2146534534 @default.
- W4313245005 cites W2166402206 @default.
- W4313245005 cites W2166672545 @default.
- W4313245005 cites W2167202145 @default.
- W4313245005 cites W2211575893 @default.
- W4313245005 cites W2235934048 @default.
- W4313245005 cites W2283665962 @default.
- W4313245005 cites W2290898376 @default.
- W4313245005 cites W2298709757 @default.
- W4313245005 cites W2312418312 @default.
- W4313245005 cites W2320374844 @default.
- W4313245005 cites W2408580586 @default.
- W4313245005 cites W2468355646 @default.
- W4313245005 cites W2523078145 @default.
- W4313245005 cites W2528006377 @default.
- W4313245005 cites W2546249790 @default.
- W4313245005 cites W2555813005 @default.
- W4313245005 cites W2578110183 @default.
- W4313245005 cites W2585333725 @default.
- W4313245005 cites W2708429798 @default.
- W4313245005 cites W2733552611 @default.
- W4313245005 cites W2737772033 @default.
- W4313245005 cites W2742978833 @default.
- W4313245005 cites W2750504927 @default.
- W4313245005 cites W2756755057 @default.
- W4313245005 cites W2788888547 @default.
- W4313245005 cites W2800752654 @default.
- W4313245005 cites W2883218779 @default.
- W4313245005 cites W2889000313 @default.
- W4313245005 cites W2900006946 @default.
- W4313245005 cites W2908092484 @default.
- W4313245005 cites W2927115307 @default.
- W4313245005 cites W2946652117 @default.
- W4313245005 cites W2968259212 @default.
- W4313245005 cites W2997946315 @default.
- W4313245005 cites W2998905016 @default.
- W4313245005 cites W3006253728 @default.
- W4313245005 cites W3009083611 @default.
- W4313245005 cites W3082482529 @default.
- W4313245005 cites W3091336767 @default.
- W4313245005 cites W3097164443 @default.
- W4313245005 cites W3109091171 @default.
- W4313245005 cites W3120494813 @default.
- W4313245005 cites W3130588434 @default.
- W4313245005 cites W3158234858 @default.
- W4313245005 cites W3158367277 @default.
- W4313245005 cites W3186118569 @default.
- W4313245005 cites W3186211590 @default.
- W4313245005 doi "https://doi.org/10.3390/pharmaceutics15010080" @default.
- W4313245005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36678709" @default.
- W4313245005 hasPublicationYear "2022" @default.