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- W4313245315 endingPage "355" @default.
- W4313245315 startingPage "355" @default.
- W4313245315 abstract "Dextran sulfate (DXS) is a hydrophilic, non-toxic, biodegradable, biocompatible and safe biopolymer. These biomedically relevant characteristics make DXS a promising building block in the development of nanocarrier systems for several biomedical applications, including imaging and drug delivery. DXS polyanion can bind with metal oxide nanomaterials, biological receptors and therapeutic drug molecules. By taking advantage of these intriguing properties, DXS is used to functionalize or construct nanocarriers for specific applications. In particular, the diagnostic or therapeutic active agent-loaded DXS nanoparticles are prepared by simple coating, formation of polyelectrolyte complexes with other positively charged polymers or through self-assembly of amphiphilic DXS derivatives. These nanoparticles show a potential to localize the active agents at the pathological site and minimize undesired side effects. As DXS can recognize and be taken up by macrophage surface receptors, it is also used as a targeting ligand for drug delivery. Besides as a nanocarrier scaffold material, DXS has intrinsic therapeutic potential. DXS binds to thrombin, acts as an anticoagulant and exhibits an inhibitory effect against coagulation, retrovirus, scrapie virus and human immunodeficiency virus (HIV). Herein, biomedical applications involving the use of DXS as nanocarriers for drugs, biomolecules, and imaging agents have been reviewed. A special focus has been made on strategies used for loading and delivering of drugs and biomolecules meant for treating several diseases, including cancer, inflammatory diseases and ocular disease." @default.
- W4313245315 created "2023-01-06" @default.
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- W4313245315 date "2022-12-26" @default.
- W4313245315 modified "2023-10-05" @default.
- W4313245315 title "Dextran Sulfate Nanocarriers: Design, Strategies and Biomedical Applications" @default.
- W4313245315 cites W1539083544 @default.
- W4313245315 cites W1814849089 @default.
- W4313245315 cites W1904256453 @default.
- W4313245315 cites W1967723529 @default.
- W4313245315 cites W1973230016 @default.
- W4313245315 cites W1974107015 @default.
- W4313245315 cites W1984421760 @default.
- W4313245315 cites W1994105307 @default.
- W4313245315 cites W1997813780 @default.
- W4313245315 cites W1998271063 @default.
- W4313245315 cites W2000798536 @default.
- W4313245315 cites W2001338329 @default.
- W4313245315 cites W2008411330 @default.
- W4313245315 cites W2009826568 @default.
- W4313245315 cites W2018877291 @default.
- W4313245315 cites W2030181469 @default.
- W4313245315 cites W2036674528 @default.
- W4313245315 cites W2038820734 @default.
- W4313245315 cites W2043595382 @default.
- W4313245315 cites W2046678955 @default.
- W4313245315 cites W2047161363 @default.
- W4313245315 cites W2049592726 @default.
- W4313245315 cites W2056485384 @default.
- W4313245315 cites W2064258113 @default.
- W4313245315 cites W2072983848 @default.
- W4313245315 cites W2074438676 @default.
- W4313245315 cites W2078658784 @default.
- W4313245315 cites W2079444555 @default.
- W4313245315 cites W2082800225 @default.
- W4313245315 cites W2083849891 @default.
- W4313245315 cites W2084529811 @default.
- W4313245315 cites W2086374939 @default.
- W4313245315 cites W2086498867 @default.
- W4313245315 cites W2087852082 @default.
- W4313245315 cites W2096379568 @default.
- W4313245315 cites W2099495608 @default.
- W4313245315 cites W2103914087 @default.
- W4313245315 cites W2107809838 @default.
- W4313245315 cites W2110826367 @default.
- W4313245315 cites W2111696577 @default.
- W4313245315 cites W2124591027 @default.
- W4313245315 cites W2128530763 @default.
- W4313245315 cites W2142259199 @default.
- W4313245315 cites W2145479159 @default.
- W4313245315 cites W2149026148 @default.
- W4313245315 cites W2159964682 @default.
- W4313245315 cites W2172117878 @default.
- W4313245315 cites W2193900939 @default.
- W4313245315 cites W2287860045 @default.
- W4313245315 cites W2291156263 @default.
- W4313245315 cites W2534956871 @default.
- W4313245315 cites W2555386865 @default.
- W4313245315 cites W2559976438 @default.
- W4313245315 cites W2565599824 @default.
- W4313245315 cites W2569658671 @default.
- W4313245315 cites W2592355051 @default.
- W4313245315 cites W2603631322 @default.
- W4313245315 cites W2610730976 @default.
- W4313245315 cites W2901287979 @default.
- W4313245315 cites W2969564609 @default.
- W4313245315 cites W2981076819 @default.
- W4313245315 cites W2987630388 @default.
- W4313245315 cites W3009480861 @default.
- W4313245315 cites W3035023742 @default.
- W4313245315 cites W3048899703 @default.
- W4313245315 cites W3088080553 @default.
- W4313245315 cites W3157391054 @default.
- W4313245315 cites W3162467074 @default.
- W4313245315 cites W3182974225 @default.
- W4313245315 cites W3202892257 @default.
- W4313245315 cites W3208474163 @default.
- W4313245315 cites W3211849533 @default.
- W4313245315 cites W4200231133 @default.
- W4313245315 cites W4210791608 @default.
- W4313245315 cites W4210968471 @default.
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- W4313245315 doi "https://doi.org/10.3390/ijms24010355" @default.
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- W4313245315 hasPublicationYear "2022" @default.
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